Results 41 to 50 of about 24,451 (260)
PLoS Computational Biology, 2023 Controller motifs are simple biomolecular reaction networks with negative feedback. They can explain how regulatory function is achieved and are often used as building blocks in mathematical models of biological systems.
Eivind S Haus +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Identifiability of Parameters in the Output Least Square Formulation
, 1987 Given a mathematical model of a physical process, the parameter identification problem is defined as that of determining the parameters of the model that, for a known given input, yield a given measured output.
Chavent, Guy, G. Chavent
core +1 more source
Modeling Without a Gold Standard: Stratification with Stratum-Dependent Parameters
Revstat Statistical Journal, 2014 Bayesian latent-class models have been widely applied for assessing the performance of diagnostic tests in the absence of a gold standard. We provide a short discussion on identifiability issues appearing under the absence of a gold standard, and ...
Francisco Louzada +5 more
doaj +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Image based validation of dynamical models for cell reorientation [PDF]
, 2015 A key feature of directed cell movement is the ability of cells to reorient quickly in response to changes in the direction of an extracellular stimulus.
Ladds, Graham +5 more
core +1 more source
When It Counts—Econometric Identification of the Basic Factor Model Based on GLT Structures
Econometrics, 2023 Despite the popularity of factor models with simple loading matrices, little attention has been given to formally address the identifiability of these models beyond standard rotation-based identification such as the positive lower triangular (PLT ...
Sylvia Frühwirth-Schnatter +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source