Results 51 to 60 of about 66,185 (233)

Two Optimal Strategies for Active Learning of Causal Models from Interventional Data

, 2013
From observational data alone, a causal DAG is only identifiable up to Markov equivalence. Interventional data generally improves identifiability; however, the gain of an intervention strongly depends on the intervention target, that is, the intervened ...
Alain Hauser, Andersson, Brown, Cai, Chickering, Chvátal, Eberhardt, Eberhardt, Hauser, Hauser, He, Kalisch, Kaplan, Korb, Masegosa, Meganck, Pearl, Peter Bühlmann, Peters, Rose, Rose, Settles, Spirtes, Tong, Verma   +24 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

An Objective Measure of Distributional Estimability as Applied to the Phase-Type Aging Model

Risks
The phase-type aging model (PTAM) is a class of Coxian-type Markovian models that can provide a quantitative description of the effects of various aging characteristics.
Cong Nie, Xiaoming Liu, Serge B. Provost
doaj   +1 more source

Identification of in-sample positivity violations using regression trees: The PoRT algorithm

Journal of Causal Inference, 2023
The positivity assumption is crucial when drawing causal inferences from observational studies, but it is often overlooked in practice. A violation of positivity occurs when the sample contains a subgroup of individuals with an extreme relative frequency
Danelian Gabriel, Foucher Yohann, Léger Maxime, Le Borgne Florent, Chatton Arthur   +4 more
doaj   +1 more source

Topology Agnostic Bounds on Minimum Requirements for Network Failure Identification

IEEE Access, 2021
In Boolean Network Tomography (BNT), node identifiability is a crucial property that reflects the possibility of unambiguously classifying the state of the nodes of a network as 'working' or 'failed' through end-to-end measurement paths.
Viviana Arrigoni, Novella Bartolini, Annalisa Massini   +2 more
doaj   +1 more source

Identifiability of multivariate logistic mixture models [PDF]

, 2014
Mixture models have been widely used in modeling of continuous observations. For the possibility to estimate the parameters of a mixture model consistently on the basis of observations from the mixture, identifiability is a necessary condition.
Han, JiQing, Shi, ZiQiang, Zheng, TieRan
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Space-Time Coded MC-CDMA: Blind Channel Estimation, Identifiability, and Receiver Design

EURASIP Journal on Advances in Signal Processing, 2002
Integrating the strengths of multicarrier (MC) modulation and code division multiple access (CDMA), MC-CDMA systems are of great interest for future broadband transmissions. This paper considers the problem of channel identification and signal combining/
Li Hongbin, Sun Wei
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Abnormalities on peri‐ictal diffusion‐weighted magnetic resonance imaging (DWI‐PMAs) are well‐established for patients with status epilepticus (SE), but knowledge on patterns of DWI‐PMAs and their prognostic impact is sparse. Methods This systematic review and individual participant data meta‐analysis included observational studies ...
Andrea Enerstad Bolle, Silvana Sarria‐Estrada, Thomas Bonduelle, Bertram Daniel Dynesen, Manuel Toledo, Zhu Chung Che, Kjell Heuser, Anastasios Chatzikonstantinou, Jérôme Aupy, Udaya Seneviratne, Estevo Santamarina Perez, Christoph Patrick Beier   +11 more
wiley   +1 more source