Results 51 to 60 of about 15,093 (264)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Identification of in-sample positivity violations using regression trees: The PoRT algorithm
Journal of Causal Inference, 2023 The positivity assumption is crucial when drawing causal inferences from observational studies, but it is often overlooked in practice. A violation of positivity occurs when the sample contains a subgroup of individuals with an extreme relative frequency
Danelian Gabriel +4 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A Bayesian ARMA Probability Density Estimator
EntropyA Bayesian approach for constructing ARMA probability density estimators is proposed. Such estimators are ratios of trigonometric polynomials and have a number of advantages over Fourier series estimators, including parsimony and greater efficiency under
Jeffrey D. Hart
doaj +1 more source
The Subjective Meaning of Cognitive Architecture: A Marrian Analysis
Frontiers in Psychology, 2014 Marr famously decomposed cognitive theories into three levels. Newell, Pylyshyn, and Anderson offered parallel decompositions of cognitive architectures, which are psychologically plausible computational formalisms for expressing computational models of ...
Sashank eVarma
doaj +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Topicality and the problem of “topic” in American Sign Language discourse
Linguistic Typology at the CrossroadsAmerican Sign Language (ASL) has been characterized as a topic-comment or as a topic-prominent language. But studies based on actual usage reveal a great deal of variation, leading to the proposal here that the very idea of a definable category of topic ...
Terry Janzen
doaj +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
The Asymmetric Bimodal Normal Distribution: A Tractable Mixture Model for Skewed and Bimodal Data
MathematicsWe study a parsimonious constrained two-component Gaussian mixture with symmetric locations ±λ and unequal weights controlled by α∈[−1,1]; we refer to this family as the asymmetric bimodal normal.
Hassan S. Bakouch +5 more
doaj +1 more source