Results 51 to 60 of about 30,482 (307)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Identifiability of Parameters in the Output Least Square Formulation
, 1987 Given a mathematical model of a physical process, the parameter identification problem is defined as that of determining the parameters of the model that, for a known given input, yield a given measured output.
Chavent, Guy, G. Chavent
core +1 more source
Identifiability of Latent Class Models with Covariates
, 2022 Latent class models with covariates are widely used for psychological, social, and educational research. Yet the fundamental identifiability issue of these models has not been fully addressed.
Xu, Gongjun, Ouyang, Jing
core +1 more source
A new method for a priori practical identifiability.
PLoS ONEBackground and objectivePractical identifiability analysis, i.e., ascertaining whether a model property can be determined from given data, is central to model-based data analysis in biomedicine. The main approaches used today all require that coverage of
Peter Thompson +3 more
doaj +1 more source
An Objective Measure of Distributional Estimability as Applied to the Phase-Type Aging Model
RisksThe phase-type aging model (PTAM) is a class of Coxian-type Markovian models that can provide a quantitative description of the effects of various aging characteristics.
Cong Nie, Xiaoming Liu, Serge B. Provost
doaj +1 more source
Assessing parameter identifiability for Dynamic Causal Modelling of fMRI data
Frontiers in Neuroscience, 2015 Deterministic dynamic causal modelling (DCM) for fMRI data is a sophisticated approach to analyse effective connectivity in terms of directed interactions between brain regions of interest. To date it is difficult to know if acquired fMRI data will yield
Carolin eArand +6 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Web-Based Structural Identifiability Analyzer
, 2021 International audienceParameter identifiability describes whether, for a given differential model, one can determine parameter values from model equations.
Alexey Ovchinnikov +5 more
core +1 more source
Space-Time Coded MC-CDMA: Blind Channel Estimation, Identifiability, and Receiver Design
EURASIP Journal on Advances in Signal Processing, 2002 Integrating the strengths of multicarrier (MC) modulation and code division multiple access (CDMA), MC-CDMA systems are of great interest for future broadband transmissions. This paper considers the problem of channel identification and signal combining/
Li Hongbin, Sun Wei
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source