Results 51 to 60 of about 2,273,623 (352)

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis, Shauna R. Campbell, Jonathan Jang, Eashwar Somasundaram, Chandana A. Reddy, Jacob G. Scott, Lilyana Angelov, Peter M. Anderson, Matteo Trucco, Zachary Burke, Lukas Nystrom, Nathan Mesko, Anthony Magnelli, Erin S. Murphy   +13 more
wiley   +1 more source

Whole-exome sequencing revealed a novel heterozygous variant of NF1 in a Vietnamese family with neurofibromatosis type I

Egyptian Journal of Medical Human Genetics
Background Neurofibromatosis type I (NF1) is one of the most common autosomal dominant disorders caused by mutations in the NF1 gene. Pathogenic variants in this gene induce a wide range of phenotypes, including dermal neurofibromas along nerves ...
Thao Huong Dinh, Sang Tien Trieu, Dung Trung Nghiem, Duong Thuy Nguyen   +3 more
doaj   +1 more source

Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities

, 2018
New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome, phenotype, and ...
Goldenberg, Anna, Hoffman, Michael M., Leskovec, Jure, Nguyen, Francis, Wang, Bo, Zitnik, Marinka   +5 more
core   +1 more source

A new type of identification problems: optimizing the fractional order in a nonlocal evolution equation [PDF]

, 2016
In this paper, we consider a rather general linear evolution equation of fractional type, namely a diffusion type problem in which the diffusion operator is the $s$th power of a positive definite operator having a discrete spectrum in $\R^+$.
Sprekels, Jürgen, Valdinoci, Enrico
core   +4 more sources

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Efficient Sequencing, Assembly, and Annotation of Human KIR Haplotypes

Frontiers in Immunology, 2020
The homology, recombination, variation, and repetitive elements in the natural killer-cell immunoglobulin-like receptor (KIR) region has made full haplotype DNA interpretation impossible in a high-throughput workflow.
David Roe, Jonathan Williams, Keyton Ivery, Jenny Brouckaert, Nick Downey, Chad Locklear, Rui Kuang, Rui Kuang, Martin Maiers   +8 more
doaj   +1 more source

Distribution, identification and biology of freshwater fishes in south-western Australia [PDF]

, 1998
A total of 410 sites in the major watersheds in the south-western corner of Australia, bounded by Bunbury in the north-west and just east of Albany in the south-east, were sampled for fish.
Gill, H.S., Morgan, D.L., Potter, I.C.
core   +1 more source

Sampling Local Fungal Diversity in an Undergraduate Laboratory using DNA Barcoding [PDF]

, 2014
Traditional methods for fungal species identification require diagnostic morphological characters and are often limited by the availability of fresh fruiting bodies and local identification resources.
Anderson, B. W., Bigott, A. F., Boone, M. J., Brick, S. M., delSol, J. F., Harrington, A. H., Hotchkiss, R. A., Huddleston, R. A., Kasper, E. H., McGrady, J. J., McKinnie, M. L., Ottenlips, M. V., Skinner, N. E., Spatz, K. C., Steinberg, A. J., van den Broek, F., Willyard, A. M., Wilson, C. N., Wofford, A. M   +18 more
core   +3 more sources

Identification of longevity genes with systems biology approaches

Advances and Applications in Bioinformatics and Chemistry, 2009
Identification of genes involved in the aging process is critical for understanding the mechanisms of age-dependent diseases such as cancer and diabetes. Measuring the mutant gene lifespan, each missing one gene, is traditionally employed to identify longevity genes.
Yuanyou, Tan, John M, Bush, Weijiu, Liu, Fusheng, Tang   +3 more
openaire   +3 more sources

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source