Results 71 to 80 of about 60,318 (256)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
What new cell biology findings could bring to therapeutics: is it time for a phenome-project in Toxoplasma gondii? [PDF]
, 2009 "If you know the enemy and know yourself, you need not fear the result of a hundred battles. If you know yourself but not the enemy, for every victory gained you will also suffer a defeat" (SunTzu the Art of War, 544-496 BC).
Meissner, M. +5 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
From genetic data to kinship clarity: employing machine learning for detecting incestuous relations
Frontiers in GeneticsIntroduction:The aim of the study was to develop a predictive model based on STR profiles of mothers and children for the detection of incestuous conception.Methods:Based on allele frequency data from the USA and Saudi Arabia, STR profiles were generated
Dejan Šorgić +3 more
doaj +1 more source
Who knows who we are? Questioning DNA analysis in disaster victim identification [PDF]
, 2014 The use of DNA analysis as a mode of identification of disaster victims has become increasingly predominant to other, traditional, methods of identification in recent years.
Bennett, Caroline, Caroline Bennett
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Identification of trypanosomes: from morphology to molecular biology
, 1999 One of the enduring problems in the epidemiology of sleeping sickness is that there are 3 morphologically indistinguishable subspecies of Trypanosoma brucei involved in a complex transmission cycle between humans, tsetse and reservoir hosts. Two subspecies, T. b. gambiense and T. b.
Gibson, WC, Stevens, JR, Truc, P
openaire +2 more sources
, 2020 Osteoarthritis (OA) is the most common form of joint disability in the world affecting a large number of persons s yet the mechanisms responsible for the disease is not well n understood.
Dr Prachi, srivastava +4 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source