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Surface Acoustic Wave Immunosensor for Detection of Botulinum Neurotoxin
Sensors, 2023 A Love-type acoustic wave sensor (AT-cut quartz substrate, SiO2 guiding layer) with a center frequency of approximately 120 MHz was used to detect a simulant of pathogenic botulinum neurotoxin type A—recombinant of BoNT-A light chain—in liquid samples ...
Michał Grabka +2 more
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On Botulinum Neurotoxin Variability [PDF]
mBio, 2015 ABSTRACT The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this remarkable phenomenon, we suggest that researchers should (i) abandon an anthropocentric ...
MONTECUCCO, CESARE +1 more
openaire +6 more sources
Conjugative botulinum neurotoxin-encoding plasmids in Clostridium botulinum. [PDF]
PLoS ONE, 2010 Clostridium botulinum produces seven distinct serotypes of botulinum neurotoxins (BoNTs). The genes encoding different subtype neurotoxins of serotypes A, B, F and several dual neurotoxin-producing strains have been shown to reside on plasmids ...
Kristin M Marshall +2 more
doaj +2 more sources
Toxins, 2021 Parkinson’s disease is the most common age-related motoric neurodegenerative disease. In addition to the cardinal motor symptoms of tremor, rigidity, bradykinesia, and postural instability, there are numerous non-motor symptoms as well.
Steven D Mitchell +2 more
exaly +3 more sources
Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature [PDF]
Toxins, 2017 Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which ...
Michael W. Peck +24 more
doaj +2 more sources
Anatomical Proposal for Botulinum Neurotoxin Injection for Glabellar Frown Lines [PDF]
Toxins, 2022 Botulinum neurotoxin injection for treating glabellar frown lines is a commonly used method; however, side effects, such as ptosis and samurai eyebrow, have been reported due to a lack of comprehensive anatomical knowledge.
Kyu-Ho Yi +3 more
doaj +3 more sources
Two-component signal transduction system CBO0787/CBO0786 represses transcription from botulinum neurotoxin promoters in Clostridium botulinum ATCC 3502. [PDF]
PLoS Pathogens, 2013 Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of ...
Zhen Zhang +6 more
doaj +2 more sources
Use of Botulinum Neurotoxin in Ophthalmology
Türk Oftalmoloji Dergisi, 2016 Botulinum neurotoxin (BoNT) is the first biological toxin used in the treatment of ophthalmic diseases and to decrease skin wrinkles as an aesthetic agent. When used appropriately, it weakens the force of muscular contraction and/or inhibits glandular secretion.
Basar, Emel, Arici, Ceyhun
openaire +4 more sources
Overview of botulinum neurotoxin-producing clostridia in soils in France
Microbiology SpectrumSoil is a known reservoir of human pathogens, including botulinum neurotoxin-producing clostridia. However, the occurrence and distribution of botulinum neurotoxin types in French soils are unknown, prompting this study.
Caroline Le Maréchal +11 more
doaj +2 more sources
Toxins, 2021 Intradermal injection of botulinum neurotoxin is a frequently performed procedure in aesthetic dermatology to improve facial skin tone, texture, fine wrinkles, and enlarged pores.
Nark-Kyoung Rho, Young-Chun Gil
doaj +1 more source