Results 31 to 40 of about 116,934 (269)
Acta Pharmacologica Sinica, 2023 Botulinum neurotoxin A ameliorates reserpine-induced depressive behaviors. Complement activation is involved in the reserpine-induced mouse model. Botulinum neurotoxin A reverses spine loss and reduced synapse density.
Yang Li +9 more
semanticscholar +1 more source
Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity
Science, 2021 Moving targets of neurotoxins Proteases that cleave protein targets at specific sequences control many biological functions. The ability to reprogram proteases to cleave new sequences of our choosing would enable new therapeutic and biotechnological ...
T. Blum +10 more
semanticscholar +1 more source
Toxins, 2020 The neurotoxin formed by Clostridium botulinum Group II is a major cause of foodborne botulism, a deadly intoxication. This study aims to understand the genetic diversity and spread of C. botulinum Group II strains and their neurotoxin genes.
Jason Brunt +5 more
doaj +1 more source
Toxins, 2020 Clostridium botulinum Group I and Clostridium sporogenes are closely related bacteria responsible for foodborne, infant and wound botulism. A comparative genomic study with 556 highly diverse strains of C. botulinum Group I and C.
Jason Brunt +7 more
doaj +1 more source
Toxins, 2021 Parkinson’s disease is the most common age-related motoric neurodegenerative disease. In addition to the cardinal motor symptoms of tremor, rigidity, bradykinesia, and postural instability, there are numerous non-motor symptoms as well.
Steven D. Mitchell +1 more
doaj +1 more source
Adult Intestinal Toxemia Botulism
Toxins, 2020 Intoxication with botulinum neurotoxin can occur through various routes. Foodborne botulism results after consumption of food in which botulinum neurotoxin-producing clostridia (i.e., Clostridium botulinum or strains of Clostridium butyricum type E or ...
Richard A. Harris +2 more
doaj +1 more source
Journal of Cosmetic Dermatology, 2020 The literature on botulinum neurotoxin type A (BoNT‐A) is extensive, often contradictory, and confounded by a competitive market of products and research attempting to distinguish brand individuality.
M. Nestor +2 more
semanticscholar +1 more source
Release of vasopressin from isolated permeabilized neurosecretory nerve terminals is blocked by the light chain of botulinum A toxin [PDF]
, 1990 The intracellular action on exocytosis of botulinim A toxin and constituent chains was studied using permeabilized isolated nerve endings from the rat neural lobe. The release of the neuropeptide vasopressin was measured by radioimmunoassay.
Weller, U. +4 more
core +1 more source
Botulinum Neurotoxin for the Treatment of Neuropathic Pain
Frontiers in Neurology, 2020 Botulinum neurotoxin is widely used for the treatment of central and peripherical neurological conditions. Initially used to treat strabismus, over the years its use has been expanded also to spasticity and other neurological disorders.
G. Egeo, L. Fofi, P. Barbanti
semanticscholar +1 more source
Botulinum and Tetanus Neurotoxins
Annual Review of Biochemistry, 2019 Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic ...
Min, Dong +2 more
openaire +3 more sources