Results 41 to 50 of about 20,701 (223)

Clinical Relevance of Botulinum Toxin Immunogenicity [PDF]

, 2012
Botulinum toxin type A is a 150 kD protein produced by Clostridium botulinum, which exists in a complex with up to six additional proteins. The ability of botulinum toxin to inhibit acetylcholine release at the neuromuscular junction has been exploited ...
Reiner Benecke
core   +1 more source

Microbial communities and functional diversity in seafood

JSFA reports, EarlyView.
Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi, Samuel Ayeh Osei, Grace Afumwaa Boamah, Gertrude Dzifa Mensah   +3 more
wiley   +1 more source

Botulinum Neurotoxin: The Ugly Duckling [PDF]

European Neurology, 2009
This review presents a brief account of the most significant biological effects and clinical applications of botulinum neurotoxins, in a way comprehensive even for casual readers who are not familiar with the subject. The most toxic known substances in botulinum neurotoxins are polypeptides naturally synthesized by bacteria of the genus <i> ...
openaire   +3 more sources

Patient-Reported Side Effects of Intradetrusor Botulinum Toxin Type A for Idiopathic Overactive Bladder Syndrome [PDF]

, 2011
Objective: The aim of the study was a prospective assessment of patient-reported side effects in an open-label study after intradetrusor botulinum toxin injections for idiopathic overactive bladder (OAB). Patients and Methods: Botulinum toxin A injection
Alexander Buchner, Alexander Roosen, Andersson KE, Chancellor MB, Christian G. Stief, Christian Gratzke, Cohen BL, Coyne KS, Eleopra R, Florian May, Garner CG, Jeffery S, Kalsi V, Lange DJ, Margit E. Mayer, Mehnert U, Mohanty NK, Ricarda M. Bauer, Shaban AM, Smith CP, Yasmin Hocaoglu   +20 more
core   +1 more source

Structural Basis of Botulinum Toxin Type F Binding to Glycosylated Human SV2A: In Silico Studies at the Periphery of a Lipid Raft

Biomolecules, 2022
Botulinum neurotoxins are the deadliest microbial neurotoxins in humans, with a lethal dose of 1 ng/kg. Incidentally, these neurotoxins are also widely used for medical and cosmetic purposes.
Fodil Azzaz, Didier Hilaire, Jacques Fantini   +2 more
doaj   +1 more source

The Spectrum of Abnormal Tongue Movements: Review of Phenomenology, Etiology, and Differential Diagnosis

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background Classifying abnormal tongue movements is challenging due to their varied presentations and limited visibility compared to other body parts. Accurate identification of the phenomenology guides physical examination and can point to specific diagnoses.
Nathaniel Bendahan, Seyed‐Mohammad Fereshtehnejad, Christos Ganos, Emily Swinkin, Anthony E. Lang   +4 more
wiley   +1 more source

Antipruritic Effects of Botulinum Neurotoxins [PDF]

Toxins, 2018
This review explores current evidence to demonstrate that botulinum neurotoxins (BoNTs) exert antipruritic effects. Both experimental and clinical conditions in which botulinum neurotoxins have been applied for pruritus relief will be presented and significant findings will be highlighted.
openaire   +4 more sources

Botulinum Neurotoxin Serotypes Detected by Electrochemical Impedance Spectroscopy

Toxins, 2015
Botulinum neurotoxin is one of the deadliest biological toxins known to mankind and is able to cause the debilitating disease botulism. The rapid detection of the different serotypes of botulinum neurotoxin is essential for both diagnosis of botulism and
Alison C. Savage, Nicholas Buckley, Jennifer Halliwell, Christopher Gwenin   +3 more
doaj   +1 more source

DaxibotulinumtoxinA for Injection in Adults with Cervical Dystonia: Clinical Insights from a Real‐World Early Experience Program

Movement Disorders Clinical Practice, EarlyView.
ABSTRACT Background DaxibotulinumtoxinA for injection (DAXI), a novel botulinum toxin (BoNT) formulated with a custom‐engineered peptide, was recently approved for treating cervical dystonia (CD). DAXI demonstrated a long duration of symptom relief in Phase 3 trials. Objective To report findings from PrevU, an early experience, real‐world observational
Laxman Bahroo, Aaron Ellenbogen, Robert A. Hauser, Han S. Lee, Peter McAllister, Atul T. Patel, Rashid Kazerooni, Todd M. Gross, Julia Sparrow, Conor J. Gallagher, David A. Hollander   +10 more
wiley   +1 more source

Neuronal selectivity of botulinum neurotoxins

Toxicon, 2020
Botulinum neurotoxins (BoNTs) are highly potent toxins responsible for a severe disease, called botulism. They are also efficient therapeutic tools with an increasing number of indications ranging from neuromuscular dysfunction to hypersecretion syndrome, pain release, depression as well as cosmetic application.
Poulain, Bernard, Lemichez, Emmanuel, Popoff, Michel   +2 more
openaire   +3 more sources