Results 41 to 50 of about 46,671 (223)

Guidelines for Botulinum Neurotoxin Injection for Facial Contouring

, 2022
The hypertrophied temporalis and masseter muscles give a muscular shaped and bulky contour to the face. Botulinum neurotoxin injection methods are commonly used for facial contouring; however, adverse effects have been reported owing to a lack of ...
김희진, 이형진, Hyung-Jin Lee, Hye-Won Hur, Hee-Jin Kim, Kyu-Ho Yi, Kyle K. Seo   +6 more
core   +1 more source

Botulinum Neurotoxin: The Ugly Duckling [PDF]

European Neurology, 2009
This review presents a brief account of the most significant biological effects and clinical applications of botulinum neurotoxins, in a way comprehensive even for casual readers who are not familiar with the subject. The most toxic known substances in botulinum neurotoxins are polypeptides naturally synthesized by bacteria of the genus <i> ...
openaire   +3 more sources

A Gap Analysis of Deep Brain Stimulation for Childhood‐Onset Movement Disorders

Movement Disorders, EarlyView.
Abstract Background Deep brain stimulation (DBS) is an established and increasingly utilized therapy for childhood‐onset movement disorders. However, pediatric DBS poses unique challenges that are not adequately addressed by adult‐derived paradigms. Objective To identify key gaps in the current use of DBS in childhood‐onset movement disorders and to ...
Daniela Munoz‐Chesta, Carolina Gorodetsky, Todd M. Herrington, Angela L. Hewitt, Daniel E. Lumsden, Jennifer O'Malley, Terence Sanger   +6 more
wiley   +1 more source

Structural Basis of Botulinum Toxin Type F Binding to Glycosylated Human SV2A: In Silico Studies at the Periphery of a Lipid Raft

Biomolecules, 2022
Botulinum neurotoxins are the deadliest microbial neurotoxins in humans, with a lethal dose of 1 ng/kg. Incidentally, these neurotoxins are also widely used for medical and cosmetic purposes.
Fodil Azzaz, Didier Hilaire, Jacques Fantini   +2 more
doaj   +1 more source

Fifteen‐Year Outcomes of Bilateral Pallidal Stimulation in Isolated Generalized Dystonia: Characterization of Therapeutic Response and Emergence of Parkinsonism

Movement Disorders, EarlyView.
Abstract Background Bilateral pallidal deep brain stimulation (GPi‐DBS) is effective for dystonia. Long‐term evolution of therapeutic benefit and emergence of parkinsonism have not been systematically characterized. Objectives To assess 15‐year dystonia outcomes and characterize parkinsonism after bilateral GPi‐DBS.
Clément Desjardins, Cécilia Bonnet, Elena Moro, David Grabli, Valérie Fraix, Marie‐Laure Welter, Laurent Vercueil, Soledad Navarro, Carine Karachi, Thibaud Charrier, Sylvie Raoul, Mathilde Guibourd de Luzinais, Emmanuel Cuny, Stéphan Chabardes, Pierre Burbaud, Dominique Guehl, Pascal Derkinderen, Marie Vidailhet, on behalf of the French SPIDY Study Group, Olivier Detante, Valérie Fraix, Pierre Pollak, Laurent Vercueil, Yves Agid, David Grabli, Jean‐Luc Houeto, Valérie Mesnage, Marie Vidailhet, Marie‐Laure Welter, Pierre Césaro, Luc Defebvre, Alain Destée, Pierre Krystkowiak, Alim‐Louis Benabid, Stephan Chabardes, Adnan Koudsie, Philippe Cornu, Soledad Navarro, Serge Blond, Gustavo Touzet, Abdelhamid Benazzouz, Bernard Pidoux, François Cassim, Sylvie Grand, Jean‐François Le Bas, Didier Dormont, Jean‐Pierre Pruvo, Christine Delmaire, Claire Ardouin, Bernard Pillon, Valérie Hahn‐Barma, Kathy Dujardin.   +51 more
wiley   +1 more source

Botulinum Neurotoxin Serotypes Detected by Electrochemical Impedance Spectroscopy

Toxins, 2015
Botulinum neurotoxin is one of the deadliest biological toxins known to mankind and is able to cause the debilitating disease botulism. The rapid detection of the different serotypes of botulinum neurotoxin is essential for both diagnosis of botulism and
Alison C. Savage, Nicholas Buckley, Jennifer Halliwell, Christopher Gwenin   +3 more
doaj   +1 more source

Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite Inhibitors

, 2016
Botulinum Neurotoxin A Protease: Discovery of Natural Product Exosite ...
Nicholas T. Salzameda (2268529), Peter Šilhár (1893691), Kateřina Čapková (2313226), Joseph T. Barbieri (460376), Mark S. Hixon (240454), Kim D. Janda (163029)   +5 more
core   +1 more source

In the human urothelium and suburothelium, intradetrusor botulinum neurotoxin type A does not induce apoptosis: preliminary results [PDF]

, 2010
Intradetrusor injections of botulinum neurotoxin type A (BoNTA) are emerging as the preferred second-line treatment for neurogenic and idiopathic overactive bladder (OAB).
Khan, Shahid, Kessler, Thomas M, Fowler, Clare J, Brandner, Sebastian, Elneil, Sohier, Roosen, Alexander, Panicker, Jalesh N, Thomas M. Kessler, Clare J. Fowler, Sohier Elneil, Shahid Khan, Jalesh N. Panicker, Alexander Roosen, Sebastian Brandner   +13 more
core   +1 more source

Comparisons of immediate efficacy of cryoneurolysis and phenol neurolysis in spasticity reduction using Modified Ashworth Scale after brain injury: A retrospective cohort study

PM&R, EarlyView.
Abstract Background Phenol neurolysis and cryoneurolysis are nerve block procedures used to manage localized spasticity through different mechanisms, chemical and cold‐induced nerve blocks, respectively. Both procedures can cause immediate reduction in spasticity. Objective To compare the immediate efficacy of cryoneurolysis versus phenol neurolysis in
Sonia Mejia, Nicholas Tan, Bei Zhang, Sheng Li   +3 more
wiley   +1 more source

CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C.

PLoS ONE, 2015
Botulinum neurotoxins produced by Clostridium botulinum cause flaccid paralysis by inhibiting neurotransmitter release at peripheral nerve terminals. Previously, we found that neurons derived from the murine P19 embryonal carcinoma cell line exhibited ...
Kentaro Tsukamoto, Chikako Ozeki, Tomoko Kohda, Takao Tsuji   +3 more
doaj   +1 more source