Results 21 to 30 of about 116,934 (269)
Therapy of Sialorrhea with Botulinum Neurotoxin [PDF]
Neurology and Therapy, 2019 Botulinum neurotoxin (BoNT) is considered the treatment of choice for various symptoms and diseases such as focal dystonia and focal spasticity. The effects of BoNT on the salivary glands have also been known for years, but their use was limited because ...
W. Jost +7 more
semanticscholar +5 more sources
On Botulinum Neurotoxin Variability [PDF]
mBio, 2015 ABSTRACT The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this remarkable phenomenon, we suggest that researchers should (i) abandon an anthropocentric ...
MONTECUCCO, CESARE +1 more
openaire +6 more sources
Central Effects of Botulinum Neurotoxin—Evidence from Human Studies
Toxins, 2019 For more than three decades, Botulinum neurotoxin (BoNT) has been used to treat a variety of clinical conditions such as spastic or dystonic disorders by inducing a temporary paralysis of the injected muscle as the desired clinical effect.
David Weise, Markus Naumann
exaly +2 more sources
Conjugative botulinum neurotoxin-encoding plasmids in Clostridium botulinum. [PDF]
PLoS ONE, 2010 Clostridium botulinum produces seven distinct serotypes of botulinum neurotoxins (BoNTs). The genes encoding different subtype neurotoxins of serotypes A, B, F and several dual neurotoxin-producing strains have been shown to reside on plasmids ...
Kristin M Marshall +2 more
doaj +2 more sources
Botulinum neurotoxin formulations: overcoming the confusion
Clinical, Cosmetic and Investigational Dermatology, 2018 Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular nonsurgical procedure worldwide.
Souphiyeh Samizadeh, K. De Boulle
semanticscholar +2 more sources
Two-component signal transduction system CBO0787/CBO0786 represses transcription from botulinum neurotoxin promoters in Clostridium botulinum ATCC 3502. [PDF]
PLoS Pathogens, 2013 Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of ...
Zhen Zhang +6 more
doaj +2 more sources
Comparison of botulinum neurotoxin type A formulations in Asia
Clinical, Cosmetic and Investigational Dermatology, 2018 Results All protein-based therapeutics, such as botulinum neurotoxin type A (BoNT/A), are potentially immunogenic and can lead to anaphylaxis, autoimmunity, or diminished or complete absence of therapeutic efficacy, especially if administered repeatedly.
J. Frevert, K. Ahn, M. Park, O. Sunga
semanticscholar +2 more sources
Use of Botulinum Neurotoxin in Ophthalmology
Türk Oftalmoloji Dergisi, 2016 Botulinum neurotoxin (BoNT) is the first biological toxin used in the treatment of ophthalmic diseases and to decrease skin wrinkles as an aesthetic agent. When used appropriately, it weakens the force of muscular contraction and/or inhibits glandular secretion.
Basar, Emel, Arici, Ceyhun
openaire +4 more sources
Intramuscular neural distribution of the soleus for botulinum neurotoxin injection: application to spasticity [PDF]
Scientific ReportsUnderstanding the nerve distribution within the soleus muscle concerning anatomical landmarks is crucial for botulinum neurotoxin injections in managing spasticity.
Kyu-Ho Yi +4 more
doaj +2 more sources
Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
Nature Communications, 2017 Botulinum neurotoxin B is a Food and Drug Administration-approved therapeutic toxin. However, it has lower binding affinity toward the human version of its major receptor, synaptotagmin II (h-Syt II), compared to mouse Syt II, because of a residue ...
Liang Tao +12 more
semanticscholar +2 more sources