Results 81 to 90 of about 2,278,996 (305)

The impact of molecular biology on assessment of water quality: advantages and limitations of current techniques [PDF]

, 1997
The advent of molecular biology has had a dramatic impact on all aspects of biology, not least applied microbial ecology. Microbiological testing of water has traditionally depended largely on culture techniques.
Saunders, J.R., Saunders, V.A.
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Identification of novel genes involved in gastric carcinogenesis by suppression subtractive hybridization [PDF]

, 2015
Gastric cancer (GC) is one of the most common and life-threatening types of malignancies. Identification of the differentially expressed genes in GC is one of the best approaches for establishing new diagnostic and therapeutic targets. Furthermore, these
Ebrahimifard, F., Mottaghi-Dastjerdi, N., Roshandel, G., Sepehrizadeh, Z., Setayesh, N., Soltany-Rezaee-Rad, M.   +5 more
core  

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity [PDF]

, 2016
Various steady state and inflamed tissues have been shown to contain a heterogeneous DC population consisting of developmentally distinct subsets, including cDC1s, cDC2s and monocyte-derived DCs, displaying differential functional specializations.
Bolli, Evangelia, Boon, Louis, De Baetselier, Patrick, Elkrim, Yvon, Geeraerts, Xenia, Guilliams, Martin, Keirsse, Jiri, Kiss, Mate, Lahmar, Qods, Laoui, Damya, Mazzone, Massimiliano, Morias, Yannick, Scott, Charlotte, Serneels, Jens, Sichien, Dorine, Van Ginderachter, Jo A., Van Overmeire, Eva   +16 more
core   +4 more sources

Identification of trypanosomes: from morphology to molecular biology

, 1999
One of the enduring problems in the epidemiology of sleeping sickness is that there are 3 morphologically indistinguishable subspecies of Trypanosoma brucei involved in a complex transmission cycle between humans, tsetse and reservoir hosts. Two subspecies, T. b. gambiense and T. b.
Gibson, WC, Stevens, JR, Truc, P
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Intramuscular neural distribution of the soleus for botulinum neurotoxin injection: application to spasticity

Scientific Reports
Understanding the nerve distribution within the soleus muscle concerning anatomical landmarks is crucial for botulinum neurotoxin injections in managing spasticity.
Kyu-Ho Yi, Hyewon Hu, Sung-Oh Hwang, Ji-Hyun Lee, Hyung-Jin Lee   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Adaptations of bite force and masseter muscle thickness to high-intensity physical training in professional athletes: a comparative cross-sectional study

BMC Sports Science, Medicine and Rehabilitation
Background This study investigated how prolonged high-intensity physical training influences bite force and masseter muscle thickness, which are key indicators of adaptation in the masticatory system.
Kyu-Lim Lee, Jun-Young Sung, Soo-Bin Kim, Hee-Jin Kim   +3 more
doaj   +1 more source