Results 101 to 110 of about 2,297,802 (295)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Networks in Biology – From Identification, Analysis to Interpretation [PDF]

, 2009
Over the last decade networks has become a unifying language in biology. Yet we are only in the beginning of understanding their significance for biology and their medical applications. I will talk about the diversity of biological networks composed either of genes, proteins, metabolites, or cells and the associated methods for finding these graphs in ...
openaire   +1 more source

Adaptations of bite force and masseter muscle thickness to high-intensity physical training in professional athletes: a comparative cross-sectional study

BMC Sports Science, Medicine and Rehabilitation
Background This study investigated how prolonged high-intensity physical training influences bite force and masseter muscle thickness, which are key indicators of adaptation in the masticatory system.
Kyu-Lim Lee, Jun-Young Sung, Soo-Bin Kim, Hee-Jin Kim   +3 more
doaj   +1 more source

Identification of novel genes involved in gastric carcinogenesis by suppression subtractive hybridization [PDF]

, 2015
Gastric cancer (GC) is one of the most common and life-threatening types of malignancies. Identification of the differentially expressed genes in GC is one of the best approaches for establishing new diagnostic and therapeutic targets. Furthermore, these
Ebrahimifard, F., Mottaghi-Dastjerdi, N., Roshandel, G., Sepehrizadeh, Z., Setayesh, N., Soltany-Rezaee-Rad, M.   +5 more
core  

An output-sensitive algorithm for the minimization of 2-dimensional String Covers

, 2019
String covers are a powerful tool for analyzing the quasi-periodicity of 1-dimensional data and find applications in automata theory, computational biology, coding and the analysis of transactional data. A \emph{cover} of a string $T$ is a string $C$ for
A Apostolico, A Apostolico, A Bacciotti, A Katok, A Muchnik, A Tychonoff, A Wlodawer, AK Brodzik, AV Aho, DE Knuth, J Kopf, JR Searle, K Perlin, L Bursill, R Middlestead, RS Bird, S Havlin, WA Sethares   +17 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source