Results 111 to 120 of about 5,717,926 (305)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Risk assessment for hydrophobic disinfectants and antiseptics as contaminants in freshwater using risk quotient and network pharmacology approaches

iScience
Summary: Increasing public use of disinfectants and antiseptics (DAs) has raised concerns about their environmental contamination and adverse effects on non-target organisms, despite critical knowledge gaps in the ecological risks posed by DAs.
Songyi Wei, Yinan Wang, Zerong Zhu, Jun Wang   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering

, 2013
Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived
Chia-Chou Wu, Bor-Sen Chen
core   +1 more source

Physical strength, body composition, and G-test results of air force cadets based on nutrition knowledge differences

Scientific Reports
The Gravitational Acceleration Test (G-test) is a demanding, and sophisticated high-intensity physical activity, greatly influenced by individual body composition and physical strength.
Jun-Young Sung, Kyu-Lim Lee
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Systems Biology Approach to Identification of Novel Drug Targets for Mycobacterium tuberculosis Infection

, 2014
These are the tables and figures for Systems Biology Approach to Identification of Novel Drug Targets for Mycobacterium tuberculosis Infection by Sarah Helmy.
Sarah Helmy (601252)
core   +1 more source

Exosome-mediated Advancements in Plastic Surgery: Navigating Therapeutic Potential in Skin Rejuvenation and Wound Healing

Plastic and Reconstructive Surgery, Global Open
Summary:. Exosomes, tiny extracellular vesicles derived from various cells such as adipose-derived stem cells, bone marrow-derived mesenchymal stem cells, and human umbilical cord mesenchymal stem cells, exhibit considerable potential in wound healing ...
Soo Yeon Park, MD, Kyu-Ho Yi, MD, PhD
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Isolation and identification of amylolytic bacteria from ragi

, 2018
Ragi is a traditional dry starter culture frequently used in many fermented food products in Asian countries. Ragi contains starch that can be degraded by amylases provided by bacteria and other microorganisms during fermentation in producing fermented ...
Maryam Mohamed Rehan, Nur Huda Faujan, Roslan R., Hanina Mohd Noor, Kamarudin K.R., Salina Mat Radzi   +5 more
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