Results 101 to 110 of about 251,062 (259)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

ICD-10 code validation for gastrointestinal bleeding in patients receiving oral anticoagulation: nationwide cohort study

BMC Gastroenterology
Background ICD-10 codes are commonly used to identify gastrointestinal bleeding (GIB) events in observational studies. However, most studies have neither used validated ICD-10 coding algorithms to identify GIB events nor manually confirmed the diagnosis ...
Arnar Bragi Ingason, Jóhann Páll Hreinsson, Arnar Snær Ágústsson, Sigrún Helga Lund, Edward Rumba, Sigríður Kristjánsdóttir, Einar Stefán Björnsson   +6 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

On cages admitting identifying codes

European Journal of Combinatorics, 2008
The motivation for identifying codes, introduced in [IEEE Trans. Inf. Theory 44, No. 2, 599--611 (1998; Zbl 1105.94342)] by \textit{M. G. Karpovsky}, \textit{K. Chakrabarty} and \textit{L. B. Levitin}, comes from finding faulty processors in a multiprocessor system.
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Development of cohort definitions and algorithms to identify patients with Lennox-Gastaut syndrome or Dravet syndrome from real-world administrative healthcare databases

Heliyon
Objective: To develop cohort definitions and algorithms that can be applied to a range of real-world retrospective data sources in the United States, France, Germany, Italy, Spain, United Kingdom, China, and Japan to identify patients with Lennox-Gastaut
Drishti Shah, Victoria Divino, Justin Chen, Arturo Benitez, Jeannine Roth, J. Scott Andrews   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Development and validation of a risk scoring system to identify patients with lupus nephritis in electronic health record data

Lupus Science and Medicine
Objective Accurate identification of lupus nephritis (LN) cases is essential for patient management, research and public health initiatives. However, LN diagnosis codes in electronic health records (EHRs) are underused, hindering efficient identification.
Christine Anastasiou, Zara Izadi, Jinoos Yazdany, Gabriela Schmajuk, Milena Gianfrancesco   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

On Iiro Honkala's contributions to identifying codes

Fundamenta Informaticae
A set $C$ of vertices in a graph $G=(V,E)$ is an identifying code if it is dominating and any two vertices of $V$ are dominated by distinct sets of codewords. This paper presents a survey of Iiro Honkala's contributions to the study of identifying codes with respect to several aspects: complexity of computing an identifying code, combinatorics in ...
Olivier Hudry, Ville Junnila, Antoine Lobstein   +2 more
openaire   +3 more sources