Results 121 to 130 of about 3,911,112 (360)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Nostalgia increases punitiveness by intensifying moral concern
Scientific ReportsWe addressed the relation between nostalgia and moral judgment or behavior. We hypothesized that nostalgia, a social emotion, increases moral concern (H1), nostalgia intensifies punitiveness against moral transgressors (H2), and that the nostalgia ...
Jannine D. Lasaleta +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Smart Contract Federated Identity Management without Third Party Authentication Services
, 2019 Federated identity management enables users to access multiple systems using a single login credential. However, to achieve this a complex privacy compromising authentication has to occur between the user, relying party (RP) (e.g., abusiness), and a ...
Dray, Jim, Mell, Peter, Shook, James
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NewsFerret : supporting identity risk identification and analysis through text mining of news stories [PDF]
, 2013 textIndividuals, organizations, and devices are now interconnected to an unprecedented degree. This has forced identity risk analysts to redefine what “identity” means in such a context, and to explore new techniques for analyzing an ever expanding ...
Golden, Ryan Christian
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Immigrants' Identity, Economic Outcomes, and the Transmission of Identity across Generations [PDF]
In this paper we address three issues relating to immigrants' identity, measured as the feeling of belonging to particular ethnic groups. We study the formation of identity with home and host countries.
Christian Dustmann, Teresa Casey
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Doing Identity in Luxembourg [PDF]
, 2011 Luxembourg - international financial center, European administrative center, destination country for immigration? This empirical study provides insights about a society that has hitherto largely eluded scientific investigation and observes the processes ...
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