Results 141 to 150 of about 2,999,482 (313)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Racial & Identity Profiling Advisory Board Annual Report 2020 [PDF]

open access: yes, 2018
California’s Racial and Identity Profiling Advisory Board (Board) is pleased to release its Third Annual Report. The Board was created by the Racial and Identity Profiling Act of 2015 (RIPA) to shepherd data collection and provide public reports with the
Racial & Identity Profiling Advisory Board
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Racial & Identity Profiling Advisory Board Annual Report 2018

open access: yes, 2018
The Racial and Identity Profiling Advisory (RIPA) Board began its work in July 2016 as part of the Racial and Identity Profiling Act of 2015 (AB 953) with a momentous purpose: to eliminate racial and identity profiling and improve racial and identity ...
Racial & Identity Profiling Advisory Board
core  

No One Can Place Me in a Box: Exploring the Identity Status of Adult Third Culture Kids [PDF]

open access: yes, 2014
Given the mixed findings on Adult Third-Culture Kids’ (ATCKs) identity development, the study explored whether ATCKs’ identity problems, particularly identity moratorium, were in fact related to their relativistic thinking developed as a result of their ...
Melles, Elizabeth Ashby
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

An Analysis of Chronic Stress, Substance Use, and Mental Health Among a Sample of Young Sexual Minority Men in New York City: The P18 Cohort Study

open access: yesYouth
Introduction: Sexual minority men (SMM) are at increased risk for psychosocial stressor exposure, substance use, and poor mental health relative to heterosexual men.
Michael Briganti   +3 more
doaj   +1 more source

Immigrants' Identity, Economic Outcomes, and the Transmission of Identity across Generations [PDF]

open access: yes
In this paper we address three issues relating to immigrants' identity, measured as the feeling of belonging to particular ethnic groups. We study the formation of identity with home and host countries.
Christian Dustmann, Teresa Casey
core  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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