Results 111 to 120 of about 18,601 (241)

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Enhancing Digital Identity and Access Control in Event Management Systems Using Sui Blockchain

IEEE Access
The evolution of blockchain technology presents transformative potential for event management, particularly in enhancing security, transparency, and efficiency across the industry.
Suthir Sriram, P. R. Tharaniesh, Priyanka Saraf, Nivethitha Vijayaraj, Thangavel Murugan   +4 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Zero trust-driven access control delegation using blockchain

Blockchain: Research and Applications
As digital ecosystems become more complex with decentralized technologies like the Internet of Things (IoT) and blockchain, traditional access control models fail to meet the security needs of dynamic, high-risk environments.
Rahma Mukta, Shantanu Pal, Kowshik Chowdhury, Michael Hitchens, Hye-young Paik, Salil S. Kanhere   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Identity and Access Management in Information Systems

, 2018
Bakalářská práce je zaměřena na analýzu přístupu ke správě identit v informačních systé-mech a její aplikaci v malých a velkých firmách. Práce je rozdělena do 5 částí. V teoretické části provádím rešerši správy identit a přístupů v informačních systémech.
Tesáček, Aleš
core   +2 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Validating the IAMS Framework

, 2012
The wide spread of services on the internet has aggravated the issue of maintaining multiple identities such as the virtual identities that are based on specific login credentials like username, passwords and PINs.
Wald, Mike, Alotaibi, Sara Jeza
core   +1 more source

A secure, privacy-preserving, and cost-efficient decentralized cloud storage framework using blockchain

Journal of King Saud University: Computer and Information Sciences
Cloud services benefit countless users worldwide due to notable features, such as on-demand self-service, scalability, easy maintenance, etc. Secure storage and access to data in the cloud is critical.
Swatisipra Das, Minati Mishra, Rojalina Priyadarshini, Rabindra Kumar Barik, Manob Jyoti Saikia   +4 more
doaj   +1 more source