Results 121 to 130 of about 179,881 (285)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Royal Society Open ScienceSome of the most pressing challenges facing our planet—such as climate change, biodiversity loss, warfare and extreme poverty—require social cohesion and prosocial action on a global scale. How can this be achieved?
Lukas Reinhardt, Harvey Whitehouse
doaj +1 more source
identity fusion and its influence in memory.pdf
, 2016 Purpose: From the assumption that identity fusion will influence the processes of remembrance, this works propose that individuals classified as fused will remembermore in detail certain events of their countries, and the influence of these events will ...
Ana María Aguilera-Luque (3596960)
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A New Pathway to University Retention? Identity Fusion With University Predicts Retention Independently of Grades. [PDF]
Soc Psychol Personal Sci, 2021 Talaifar S +5 more
europepmc +1 more source
ValDifi - Validation of identity fusion measures in children
Identity fusion is an intense feeling of “oneness” with the group, which motivates individuals to engage in costly pro-group behaviours. Whereas there is ample literature on identity fusion in adults, almost nothing is known about the development of ...
Antonia Misch +2 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Hermeneutic Encounters: English Teachers’ Professional Growth and Identity Formation in Light of Gadamer’s Fusion of Horizons [PDF]
This study employs Gadamer’s fusion of horizons framework to explore the transformative role of professional development (PD) workshops in shaping the professional identity and practices of young learners’ English language teachers.
Pourya Javahery,Mahshid Shafiee
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source