Results 141 to 150 of about 2,734,611 (289)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

How shared suffering bonded Britons witnessing the Queen’s funeral

Scientific Reports
Previous research suggests that sharing emotionally intense experiences with others, for example by undergoing dysphoric collective rituals together, can lead to “identity fusion,” a visceral feeling of oneness that predicts group cohesion and self ...
Claire White, Danielle Morales, Dimitris Xygalatas, Mathilde Hernu, Anna Mathiassen, Andrew Ainsworth, Meara Geraty, Nisa Bayindir, Brooke Robinson, Harvey Whitehouse   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Shared suffering predicts prosocial commitment among Turkish earthquake survivors

Scientific Reports
Previous research suggests that the perception of shared emotion associated with personally transformative events can foster a strong form of social bonding known as ‘identity fusion’, which motivates pro-group action.
Sevgi Demiroglu, Claire White, Dimitris Xygalatas, Danielle Morales, Andrew Ainsworth, Harvey Whitehouse   +5 more
doaj   +1 more source

SELFI: Selective Fusion of Identity for Generalizable Deepfake Detection

CoRR
Face identity provides a powerful signal for deepfake detection. Prior studies show that even when not explicitly modeled, classifiers often learn identity features implicitly. This has led to conflicting views: some suppress identity cues to reduce bias, while others rely on them as forensic evidence.
Younghun Kim, Minsuk Jang, Myung-Joon Kwon, Wonjun Lee 0006, Changick Kim   +4 more
openaire   +3 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Realising fusion systems

, 2007
We show that every fusion system (saturated or not) on a p-group S is equal to the fusion system associated to a discrete group G containing S as a subgroup and such that every finite subgroup of G is conjugate to a subgroup of ...
Stancu, Radu, Leary, Ian J.
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Report by the Joint-Core Team for the Establishment of Technology Bases Required for the Development of a Fusion DEMO Reactor - Basic Concept of DEMO and Structure of Technological Issues- [PDF]

, 2015
In accordance with the request of the Working Group on Fusion Research, the Nuclear Science and Technology Committee, the Subdivision on R&D Planning and Evaluation, the Council for Science and Technology, the Ministry of Education, Culture, Sports ...
OKANO, Kunihiko, TANAKA, Teruya, OZAKI, Akira, TANIGAWA, Hisashi, TOBITA, Kenji, YAMADA, Hiroshi, KASADA, Ryuta, TAKENAGA, Hidenobu, SAKAMOTO, Ryuichi, USHIGUSA, Kenkichi, KANEKO, Osamu, SAKAMOTO, Yoshiteru   +11 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source