Results 11 to 20 of about 50,635 (295)

Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma

Cancer Cell
A subset of patients with IDH-mutant glioma respond to inhibitors of mutant IDH (IDHi), yet the molecular underpinnings of such responses are not understood. Here, we profiled by single-cell or single-nucleus RNA-sequencing three IDH-mutant oligodendrogliomas from patients who derived clinical benefit from IDHi. Importantly, the tissues were sampled on-
Avishay Spitzer, Simon Gritsch, Masashi Nomura, Alexander Jucht, Jerome Fortin, Ramya Raviram, Hannah R. Weisman, L. Nicolas Gonzalez Castro, Nicholas Druck, Rony Chanoch-Myers, John J.Y. Lee, Ravindra Mylvaganam, Rachel Lee Servis, Jeremy Man Fung, Christine K. Lee, Hiroaki Nagashima, Julie J. Miller, Isabel Arrillaga-Romany, David N. Louis, Hiroaki Wakimoto, Will Pisano, Patrick Y. Wen, Tak W. Mak, Marc Sanson, Mehdi Touat, Dan A. Landau, Keith L. Ligon, Daniel P. Cahill, Mario L. Suvà, Itay Tirosh   +29 more
openaire   +3 more sources

Oligosarcomas, IDH-mutant are distinct and aggressive [PDF]

Acta Neuropathologica, 2021
AbstractOligodendrogliomas are defined at the molecular level by the presence of an IDH mutation and codeletion of chromosomal arms 1p and 19q. In the past, case reports and small studies described gliomas with sarcomatous features arising from oligodendrogliomas, so called oligosarcomas.
Abigail K. Suwala, Marius Felix, Dennis Friedel, Damian Stichel, Daniel Schrimpf, Felix Hinz, Ekkehard Hewer, Leonille Schweizer, Hildegard Dohmen, Ute Pohl, Ori Staszewski, Andrey Korshunov, Marco Stein, Thidathip Wongsurawat, Pornsuk Cheunsuacchon, Sith Sathornsumetee, Christian Koelsche, Clinton Turner, Emilie Le Rhun, Angelika Mühlebner, Philippe Schucht, Koray Özduman, Takahiro Ono, Hiroaki Shimizu, Marco Prinz, Till Acker, Christel Herold-Mende, Tobias Kessler, Wolfgang Wick, David Capper, Pieter Wesseling, Felix Sahm, Andreas von Deimling, Christian Hartmann, David E. Reuss   +34 more
openaire   +10 more sources

IDH inhibition in gliomas [PDF]

Nature Reviews Neurology
Gliomas are the most common malignant primary brain tumours in adults and cannot usually be cured with standard cancer treatments. Gliomas show intratumoural and intertumoural heterogeneity at the histological and molecular levels, and they frequently contain mutations in the isocitrate dehydrogenase 1 (IDH1) or IDH2 gene. IDH-mutant adult-type diffuse
Rudà, Roberta, Horbinski, Craig, van den Bent, Martin, Preusser, Matthias, Soffietti, Riccardo   +4 more
openaire   +2 more sources

Study on the mechanism of inhibiting patulin production by fengycin

Open Life Sciences, 2022
Penicillium expansum is the main cause of apple rot. Besides, it can also produce mycotoxin patulin (PAT). Therefore, the search for substances that can inhibit the activity and toxigenicity of P. expansum has become a hot research topic.
Fu Ruimin, Tang Wei, Zhang Hong, Zhang Yulian, Wang Ding, Chen Wuling   +5 more
doaj   +1 more source

Approaches to PET Imaging of Glioblastoma

Molecules, 2020
Glioblastoma multiforme (GBM) is the deadliest type of brain tumor, affecting approximately three in 100,000 adults annually. Positron emission tomography (PET) imaging provides an important non-invasive method of measuring biochemically specific targets
Lindsey R. Drake, Ansel T. Hillmer, Zhengxin Cai   +2 more
doaj   +1 more source

Imaginar una forma neobarrotóxica de leer y escribir la materia. Aproximaciones al poemario Los ligámenes de Mauro Césari

Aisthesis, 2022
El presente trabajo propone una lectura del libro de poemas Los ligámenes de Mauro Césari. Parte de la “escena” de la catástrofe que el libro repone: el colapso de dos diques mineros en Minas Gerais y el avance de un alud de barro tóxico sobre el poblado
Franca Maccioni
doaj   +1 more source

Echocardiographic Evaluation of Cardiac Dysfunction in Hemodialysis Patients with or without Intradialytic Hypertension [PDF]

International Journal of Medical Arts, 2022
Background: Intradialytic hypertension [IDH] is an increase in systolic blood pressure [SBP] of more than 10 mm Hg over pre-dialysis SBP, which is a serious consequence of hemodialysis [HD].
Mohamed Siam, Emad Allam, Ahmed Al-Adl, Tamer Abd Elkader, Marwa Byomy   +4 more
doaj   +1 more source

FarmFit Insights Hub Analytics Code Repository

, 2023
<h2>FarmFit Insights Hub Analytics</h2> <p><a href="https://farmfitinsightshub.org/">FarmFit Insights Hub</a> is a platform focused on understanding of how smallholder inclusive business models can deliver positive outcomes ...
Čengić, Mirza
core   +1 more source

The mechanisms of IDH mutations in tumorigenesis [PDF]

Cell Research, 2012
Tumor-associated mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes result in the loss of normal catalytic activity, the production of α-ketoglutarate (α-KG), and gain of a new activity, the production of an oncometabolite, R-2-hydroxylglutarate (R-2-HG).
Dan, Ye, Yue, Xiong, Kun-Liang, Guan
openaire   +2 more sources

Updates in IDH-Wildtype Glioblastoma

Neurotherapeutics, 2022
Glioblastoma is the most aggressive primary brain tumor with a poor prognosis. The 2021 WHO CNS5 classification has further stressed the importance of molecular signatures in diagnosis although therapeutic breakthroughs are still lacking. In this review article, updates on the current and novel therapies in IDH-wildtype GBM will be discussed.
Jawad M. Melhem, Jay Detsky, Mary Jane Lim-Fat, James R. Perry   +3 more
openaire   +2 more sources