Results 11 to 20 of about 37,577 (242)
PROGNOSIS IN IDH-MUTANT AND IDH-WILD TYPE GLIOBLASTOMA
Cumhuriyet Medical Journal, 2021 Glioblastoma (GBM) is the most common brain tumor in adults with a poor prognosis and predominantly astrocytic differentiation. GBM is classified according to the isocitrate dehydrogenase (IDH) mutation according to the World Health Organization (WHO) Brain Tumors 2016 classification.
KILIÇ, Eren +6 more
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Bringing IDH into the Fold [PDF]
Cancer Cell, 2016 Glioma-associated mutations in IDH1 or IDH2 lead to aberrant DNA methylation. A recent paper shows that loss of methylation-sensitive CTCF binding in IDH mutant cells leads to disruption of enhancer boundary function, which results in aberrant activation of PDGFRA expression via an enhancer associated with an adjacent gene.
Zadeh, Gelareh, Aldape, Kenneth
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The mechanisms of IDH mutations in tumorigenesis [PDF]
Cell Research, 2012 Tumor-associated mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes result in the loss of normal catalytic activity, the production of α-ketoglutarate (α-KG), and gain of a new activity, the production of an oncometabolite, R-2-hydroxylglutarate (R-2-HG).
Dan, Ye, Yue, Xiong, Kun-Liang, Guan
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Updates in IDH-Wildtype Glioblastoma
Neurotherapeutics, 2022 Glioblastoma is the most aggressive primary brain tumor with a poor prognosis. The 2021 WHO CNS5 classification has further stressed the importance of molecular signatures in diagnosis although therapeutic breakthroughs are still lacking. In this review article, updates on the current and novel therapies in IDH-wildtype GBM will be discussed.
Jawad M. Melhem +3 more
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Paisaje, Lengua e Interioridad en el Haiku Moderno
Mirai, 2022 El presente trabajo aborda las transformaciones del haiku desde principios de siglo XX. Basándonos en la teorización del descubrimiento del paisaje y de la interioridad de Karatani Kojin, ampliamos dicha hipótesis al descubrimiento de la lengua.
Julia Jorge
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Revista de Economía, 2010 El objetivo del presente estudio es conocer el grado de desarrollo que se ha alcanzado en la sección municipal de Sabancuy, localizada en el municipio del Carmen, Campeche, México, utilizando la metodología del programa de las Naciones Unidas para el ...
Ileana Mercedes Canepa Pérez +1 more
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Echocardiographic Evaluation of Cardiac Dysfunction in Hemodialysis Patients with or without Intradialytic Hypertension [PDF]
International Journal of Medical Arts, 2022 Background: Intradialytic hypertension [IDH] is an increase in systolic blood pressure [SBP] of more than 10 mm Hg over pre-dialysis SBP, which is a serious consequence of hemodialysis [HD].
Mohamed Siam +4 more
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Mutant IDH Inhibitors Induce Lineage Differentiation in IDH-mutant Oligodendroglioma [PDF]
, 2021 Summary Recent data showed promising signs of objective tumor responses in subsets of patients with low grade glioma treated with inhibitors of mutant IDH (IDHi) (1). However, the molecular and cellular underpinnings of such responses are not known.
Avishay Spitzer +18 more
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Pensum, 2023 El artículo pretende desentrañar las lógicas de producción de distinción social en un barrio cerrado en altura en Córdoba, Argentina. Para ello, retomamos un trabajo etnográfico, con el objetivo de describir e interpretar la diversidad de sentidos y ...
María Victoria Díaz Marengo
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Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source