Results 31 to 40 of about 50,635 (295)

Targeting IDH-Mutant Glioma

Neurotherapeutics, 2022
Standard treatment for patients with IDH-mutant gliomas with radiation therapy and chemotherapy is non-curative and associated with long-term neurotoxicity. This has created intense interest in targeted therapeutic strategies that are specifically designed of IDH-mutant tumors.
openaire   +2 more sources

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Autonomic regulation in different hypertensive phenotypes - the HELIUS study

Blood Pressure, 2023
Background: Hypertension can be classified into different phenotypes based on systolic and diastolic blood pressure (BP) that carry a different prognosis and may therefore be differently associated with sympathetic activity.
D. Collard, E.M.C. Vriend, H. Galenkamp, E.P. Moll van Charante, L. Vogt, B.E. Westerhof, B.J.H. van den Born   +6 more
doaj   +1 more source

Por una lingüística inespecífica: la inquietud ancestral de la voz

Aisthesis, 2022
En este artículo abordamos la pregunta por la materia de la voz a partir de dos nociones centrales: articulación y ancestralidad, en el marco de la propuesta singular de una lingüística insumisa, imaginada, indisciplinar, inespecífica.
Gabriela Milone
doaj   +1 more source

IDH

, 2012
Previously unpublished IDH ...
Pille Gerhold (2924181), Toomas Tammaru (826195), Javoiš, Juhan, Davis, Robert B., Õunap, Erki, Erki Õunap (3259251), Juhan Javoiš (3259248), Tammaru, Toomas, Gerhold, Pille, Robert B. Davis (3259254)   +9 more
core   +1 more source

La “verdadera electrónica”. Una aproximación etnográfica a los sentidos ligados a la música electrónica de baile en Córdoba, Argentina

Música Oral del Sur, 2023
Este texto busca problematizar los mecanismos involucrados en la producción de rótulos clasificatorios orientados a describir la música, y su relevancia como etiquetas sociológicas que también organizan la experiencia de la vida social en diversas ...
Rocío María Rodríguez
doaj   +1 more source

Stalled oligodendrocyte differentiation in IDH-mutant gliomas

, 2023
Roughly 50% of adult gliomas harbor isocitrate dehydrogenase (IDH) mutations. According to the 2021 WHO classification guideline, these gliomas are diagnosed as astrocytomas, harboring no 1p19q co-deletion, or oligodendrogliomas, harboring 1p19q co ...
Wu, Fan, Fan, Xiaolong, Qi, Xueling, Zhang, Wei, Li, Jiuyi, Jakola, Asgeir Store,, Su, Xiaodong, Carén, Helena,, Zhang, Yunqiu, Duan, Zejun, Sun, Yingyu, Feng, Jing, Ferreyra Vega, Sandra,, Jiang, Tao, Wei, Yanfei, Li, Guanzhang, Bao, Zhaoshi, Zhao, Zheng   +17 more
core   +1 more source

Reinforcements and augmentations with the long head of the biceps tendon in shoulder surgery: a narrative review

EFORT Open Reviews
The long head of the biceps tendon (LHBT) has recently emerged as a therapeutic option for various shoulder pathologies. Synthetic materials and allografts have not shown sufficient resistance or favorable outcomes to restore rotator cuff native tissue ...
Alberto Guevara-Alvarez, Edwin Valencia-Ramón, Alejandro Lopez-Villers, Luis Fernando Navarro-Pérez, Israel Gonzalez-Rizo, Gonzalo Eduardo Gomez, Alexandre Laedermann   +6 more
doaj   +1 more source

Modelling MR and clinical features in grade II/III astrocytomas to predict IDH mutation status.

, 2019
Background and purposeThere is increasing evidence that many IDH wildtype (IDHwt) astrocytomas have a poor prognosis and although MR features have been identified, there remains diagnostic uncertainty in the clinic.
Rees, Jeremy, Jha, Ashwani, Milic, Marina, Brandner, Sebastian, Nachev, Parashkev, Hyare, Harpreet, Thust, Stefanie, Rice, Louise   +7 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source