Results 31 to 40 of about 37,577 (242)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Alonso, Jimena, Fabiana Larrobla y Mariana Risso. Avanzar a tientas: cronología de las luchas por verdad y justicia: 1985 - 2015. Uruguay: Mastergraf, 2016

Historia y Memoria, 2019
Reseña crítica del libro Avanzar a tientas: cronología de las luchas por verdad y justicia: 1985 - 2015 de Jimena Alonso, Fabiana Larrobla y Mariana Risso.
Paula Zubillaga
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

El suicidio como problema gubernamental en la ciudad de Córdoba, Argentina

Revista Ñanduty, 2019
En este trabajo me propongo indagar respecto de la producción social del suicidio como problema gubernamental en la ciudad de Córdoba/Argentina de los últimos años.
Santiago Manuel Romero
doaj   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma

Cancer Cell
A subset of patients with IDH-mutant glioma respond to inhibitors of mutant IDH (IDHi), yet the molecular underpinnings of such responses are not understood. Here, we profiled by single-cell or single-nucleus RNA-sequencing three IDH-mutant oligodendrogliomas from patients who derived clinical benefit from IDHi. Importantly, the tissues were sampled on-
Avishay Spitzer, Simon Gritsch, Masashi Nomura, Alexander Jucht, Jerome Fortin, Ramya Raviram, Hannah R. Weisman, L. Nicolas Gonzalez Castro, Nicholas Druck, Rony Chanoch-Myers, John J.Y. Lee, Ravindra Mylvaganam, Rachel Lee Servis, Jeremy Man Fung, Christine K. Lee, Hiroaki Nagashima, Julie J. Miller, Isabel Arrillaga-Romany, David N. Louis, Hiroaki Wakimoto, Will Pisano, Patrick Y. Wen, Tak W. Mak, Marc Sanson, Mehdi Touat, Dan A. Landau, Keith L. Ligon, Daniel P. Cahill, Mario L. Suvà, Itay Tirosh   +29 more
openaire   +2 more sources

P04.12 Characteristics of IDH-mutant gliomas with non-canonical IDH mutations [PDF]

Neuro-Oncology, 2019
Abstract BACKGROUND About 10% of IDH-mutant gliomas harbor non-canonical IDH mutations (non-R132H IDH1 and IDH2 mutations). The aim of the present study was to analyze the characteristics of these gliomas in comparison to those of IDH1 R132H mutant gliomas.
L Poetsch, C Dehais, J Frénel, A Siegfried, S Lacomme, R Seizeur, D Larrieu-Ciron, D Cappellen, D Loussouarn, C Ferec, S Eimer, C Carpentier, M Sanson, J Delattre, D Figarella-Branger, F Ducray, C Bronnimann   +16 more
openaire   +1 more source

“Adorno” como empresa familiar. Acerca de Gretel Karplus Adorno

Avatares de la Comunicación y la Cultura, 2023
Este trabajo se propone recuperar el nombre de Gretel Karplus Adorno, colega, compañera y esposa del célebre filósofo alemán Th. W. Adorno. Su influencia en el Instituto de Investigación Social y en la empresa adorniana habitualmente es reducida a la ...
Manuel Molina
doaj   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source