Results 41 to 50 of about 50,635 (295)

Repertorios de legitimación e impugnación moral de las desigualdades. Un estudio de las fronteras simbólicas de clase en Gran Córdoba, Argentina (2003-2015)

Revista Mexicana de Ciencias Políticas y Sociales, 2019
Este artículo analiza los sentidos lego y las justificaciones morales que transmutan las desigualdades estructurales en diferencias significativas o simbólicas entre las clases sociales en familias de Gran Córdoba, Argentina.
Gonzalo Assusa
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Early onset acute lymphocytic interstitial pneumonitis (ALIP) in COVID-19 pathophysiology: preliminary lung autopsy findings

Sri Lanka Journal of Medicine, 2021
Sri Lanka is one of few countries which has performed post mortem examinations in deaths due to SARS CoV-2 virus (COVID-19) infection. At the office of the Judicial Medical Officer of National Institute of Infectious Diseases (NIID)/Infectious Disease ...
S. D. C. Perera
doaj   +1 more source

Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology [PDF]

, 2013
INTRODUCTION: Recent discoveries of inherited glioma risk loci and acquired IDH mutations are providing new insights into glioma etiology. IDH mutations are common in lower grade gliomas and secondary glioblastomas and uncommon in primary glioblastomas ...
Rice, Terri, Wiemels, Joe L, Smirnov, Ivan, Tihan, Tarik, Lachance, Daniel H, Eckel-Passow, Jeanette E, Wrensch, Margaret R, Prados, Michael D, Wiencke, John K, O'Neill, Brian Patrick, Walsh, Kyle M, McCoy, Lucie S, Xiao, Yuanyuan, Decker, Paul A, Giannini, Caterina, Zheng, Shichun, Chang, Susan M, Jenkins, Robert B, Fink, Stephanie, Bracci, Paige, Hansen, Helen M, Sicotte, Hugues, Patoka, Joseph S, Hsuang, George, Berger, Mitchel S, Caron, Alissa, Kollmeyer, Thomas, Fridley, Brooke L, Rynearson, Amanda, Pico, Alexander R, Voss, Jesse, Kosel, Matthew L   +31 more
core   +1 more source

Sirtuin activation targets IDH-mutant tumors

, 2021
Background. Isocitrate dehydrogenase (IDH)-mutant tumors exhibit an altered metabolic state and are critically dependent upon nicotinamide adenine dinucleotide (NAD+) for cellular survival.
Banagis, Jack A., Fink, Alexandria, Melamed, Lisa, Tummala, Shilpa S., Cahill, Daniel P., Tateishi, Kensuke, Nagashima, Hiroaki, Wakimoto, Hiroaki, Tummala, Srinivas, Miller, Julie J., Subramanian, Megha, Lee, Christine K.   +11 more
core   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Correlation of immune phenotype with IDH mutation in diffuse glioma

, 2020
BACKGROUND: Tumor infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1) are targets of immune checkpoint inhibitors. METHODS: Forty-three World Health Organization (WHO) grade II/III gliomas (39 IDH-mutant [mut], 4 IDH-wildtype [wt ...
Wilhelm, D, Kurscheid, Sebastian, Widhalm, Georg, Wohrer, A, Hegi, Monika E, Berghoff, Anna Sophie, Kiesel, Barbara, Rajky, Orsolya, Kresl, P, Marosi, Christine, Preusser, Matthias   +10 more
core   +2 more sources

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Alonso, Jimena, Fabiana Larrobla y Mariana Risso. Avanzar a tientas: cronología de las luchas por verdad y justicia: 1985 - 2015. Uruguay: Mastergraf, 2016

Historia y Memoria, 2019
Reseña crítica del libro Avanzar a tientas: cronología de las luchas por verdad y justicia: 1985 - 2015 de Jimena Alonso, Fabiana Larrobla y Mariana Risso.
Paula Zubillaga
doaj   +1 more source