Results 41 to 50 of about 37,577 (242)
REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma
Advanced Science, EarlyView.Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu +20 more
wiley +1 more source
Revista Mexicana de Ciencias Políticas y Sociales, 2019 Este artículo analiza los sentidos lego y las justificaciones morales que transmutan las desigualdades estructurales en diferencias significativas o simbólicas entre las clases sociales en familias de Gran Córdoba, Argentina.
Gonzalo Assusa
doaj +1 more source
Advanced Science, EarlyView.ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai +11 more
wiley +1 more source
Advanced Science, EarlyView.Glioma resection surgery is challenging because of the infiltrative growth of the tumor into nearby tissue and the different surgical requirements for gliomas with different mutation types. To improve the precision and effectiveness of glioma resection, this study developed a new imaging probe that enables the tumor boundary and mutation status to be ...
Dongdong Wu +12 more
wiley +1 more source
Atribución intencional en esquizofrenia de tipo desorganizada: una perspectiva davidsoniana
Tópicos, 2017 Actualmente se debate si el enfoque davidsoniano de la atribución intencional puede extenderse a casos de sujetos delirantes que sufren diversos trastornos psiquiátricos.
María Emilia Vilatta
doaj +1 more source
Sri Lanka Journal of Medicine, 2021 Sri Lanka is one of few countries which has performed post mortem examinations in deaths due to SARS CoV-2 virus (COVID-19) infection. At the office of the Judicial Medical Officer of National Institute of Infectious Diseases (NIID)/Infectious Disease ...
S. D. C. Perera
doaj +1 more source
Advanced Science, EarlyView.A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li +13 more
wiley +1 more source
El tiempo de la lectura en la obra de Pierre Bayard
Revista de Literatura, 2020 En este trabajo proponemos una interpretación de la crítica de anticipación de Pierre Bayard con el objetivo de indagar en el aspecto temporal de la experiencia de la lectura en el marco de una teoría de la lectura.
Nicolás Garayalde
doaj +1 more source
Práticas da História, 2023 La Nueva Escuela Histórica nucleó a un grupo de historiadores argentinos, desde la segunda década de siglo XX, que, de la mano de un amplio despliegue institucional e importantes proyectos de difusión, buscaban definir con precisión los márgenes de la ...
María Carla Galfione
doaj +1 more source
Advanced Science, EarlyView.In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu +12 more
wiley +1 more source