Results 61 to 70 of about 50,635 (295)

“Adorno” como empresa familiar. Acerca de Gretel Karplus Adorno

Avatares de la Comunicación y la Cultura, 2023
Este trabajo se propone recuperar el nombre de Gretel Karplus Adorno, colega, compañera y esposa del célebre filósofo alemán Th. W. Adorno. Su influencia en el Instituto de Investigación Social y en la empresa adorniana habitualmente es reducida a la ...
Manuel Molina
doaj   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

El tiempo de la lectura en la obra de Pierre Bayard

Revista de Literatura, 2020
En este trabajo proponemos una interpretación de la crítica de anticipación de Pierre Bayard con el objetivo de indagar en el aspecto temporal de la experiencia de la lectura en el marco de una teoría de la lectura.
Nicolás Garayalde
doaj   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Evidencias del Desarrollo Humano en Argentina: desequilibrio regional. Situación de las provincias del nordeste en las dos últimas décadas (1996-2016)

Geográfica Digital, 2018
Las disparidades regionales reflejadas por el comportamiento del Indicador de Desarrollo Humano (IDH) y sus dimensiones vienen siendo de particular interés tanto en mis prácticas docentes como en algunos trabajos de investigación desde la década de los ...
Vilma Lilian Falcón
doaj   +1 more source

Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance

, 2023
Mutations in IDH genes occur frequently in acute myeloid leukemia (AML) and other human cancers to generate the oncometabolite R-2HG. Allosteric inhibition of mutant IDH suppresses R-2HG production in a subset of patients with AML; however, acquired ...
Dickerson, Kathryn E, Burd, Amy, Chen, Mingyi, Lyu, Junhua, Gu, Zhimin, Xu, Jian, Cao, Hui, Borate, Uma, Patel, Prapti, Madanat, Yazan F, Ni, Min, Chen, Weina, Cai, Feng, Liu, Yuxuan, Yin, C Cameron, DeBerardinis, Ralph J, Kaphle, Pranita, Kalkan, Fatma N, Collins, Robert H, Stephens, Helen, Gong, Lihu, Zhang, Yuannyu, Kim, Yoon Jung, Liu, Xin, Chung, Stephen S, Cai, Sheng F, You, M James, Mims, Alice S   +27 more
core   +1 more source

SDS‐CRISPR for Single‐Nucleotide Variant Detection

Advanced Science, EarlyView.
Structure‐disruption‐sensitive CRISPR (SDS‐CRISPR) converts structural instability into single‐nucleotide precision, thereby overcoming mismatch tolerance in canonical Cas12a and enabling versatile diagnostics across DNA, RNA, and microRNA targets. When applied to rapid IDH1 mutation detection for glioma genotyping and integrated with lateral‐flow ...
Xin Guan, Chong Guo, Jiongyu Zhang, Rui Yang, Yerramsetti Ramachandra, Chengyu Hou, Minjie Pei, Shuo Zhang, Kurt T. Schalper, Xingye Liu, Qian Wu, Ketan R. Bulsara, Changchun Liu   +12 more
wiley   +1 more source

Farmer Survey Question Library

<p>Developed by <a href="https://akvo.org/" target="_self">Akvo</a> for <a href="https://www.idhsustainabletrade.com/" target="_self">IDH</a>, this question library forms the basis of the standardized survey ...
Brouwer, Jildemarie, Baruffa, Oscar, Keijser, Charlotte, Miriti, Mercy Makena   +3 more
core   +1 more source

IDH mutant high-grade gliomas [PDF]

Gliomas are the most common type of malignant primary central nervous system (CNS) tumors, resulting in significant morbidity and mortality in children and adolescent and young adult (AYA) patients. The discovery of mutations in isocitrate dehydrogenase (
Maryam Fouladi, Santosh Valvi, Michael J. Fisher, Nicholas G. Gottardo   +3 more
core   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source