Results 191 to 200 of about 63,359 (335)

Molecular profile of adult primary leptomeningeal gliomatosis aligns with glioblastoma, IDH‐wildtype

Brain Pathology, Volume 35, Issue 4, July 2025.
The molecular profile of adult primary leptomeningeal gliomatosis closely aligned with that of adult‐type glioblastoma, IDH‐wildtype, CNS WHO grade 4. Abstract Adult primary leptomeningeal gliomatosis (PLG) is a rare, rapidly progressive and fatal disease characterized by prominent leptomeningeal infiltration by a glial tumor without an identifiable ...
Yi Zhu, Darin D. Carabenciov, Derek R. Johnson, Jorge A. Trejo‐Lopez, Aivi T. Nguyen, Aditya Raghunathan, Giuseppe Lanzino, Cristiane M. Ida, Cinthya J. Zepeda‐Mendoza, Surendra Dasari, Emilie Russler‐Germain, Sonika Dahiya, Martha Quezado, Kenneth Aldape, Caterina Giannini   +14 more
wiley   +1 more source

BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: a histological and molecular analysis focusing on intratumoral heterogeneity [PDF]

, 2019
学位記番号 ...
Nakajima, Nozomi, ナカジマ, ノゾミ, 中島, 希   +2 more
core  

Resource availability for CNS tumor diagnostics in the Asian Oceanian region: A survey by the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions (AOSNP‐ADAPTR)

Brain Pathology, Volume 35, Issue 4, July 2025.
Asian Oceanian Society of Neuropathology‐Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions survey provides an overview of in‐house/ local and outsourcing resources in Asian Oceanian region for brain tumor diagnostics according to World Health Organization classification of Central Nervous System tumors.
Chitra Sarkar, Shilpa Rao, Vani Santosh, Maysa Al‐Hussaini, Sung Hye Park, Tarik Tihan, Michael E. Buckland, Ho‐Keung Ng, Takashi Komori   +8 more
wiley   +1 more source

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Nature, 2010
L. Dang, D. White, S. Gross, Bryson D. Bennett, M. Bittinger, E. Driggers, V. Fantin, H. G. Jang, Shengfang Jin, M. Keenan, K. Marks, R. Prins, P. Ward, K. Yen, L. Liau, J. Rabinowitz, L. Cantley, C. Thompson, M. V. Heiden, Shinsan M. Su   +19 more
semanticscholar   +1 more source

Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.

The Lancet Oncology, 2020
G. Abou-Alfa, T. Macarulla, M. Javle, R. Kelley, S. Lubner, J. Adeva, J. Cleary, D. Catenacci, M. Borad, J. Bridgewater, W. Harris, A. Murphy, D. Oh, J. Whisenant, M. Lowery, L. Goyal, R. Shroff, A. El-Khoueiry, Bin Fan, Bin Wu, Christina X. Chamberlain, Liewen Jiang, C. Gliser, S. Pandya, J. Valle, A. Zhu   +25 more
semanticscholar   +1 more source

SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors

Cell Research, 2022
Xiaoming Wang, Ziqi Chen, Jun Xu, Shuai Tang, Nan An, Lei Jiang, Yixiang Zhang, Shaoying Zhang, Qingli Zhang, Yan-yan Shen, Shijie Chen, Xiaojing Lan, Ting Wang, Linhui Zhai, Siyuwei Cao, Si-qi Guo, Yingluo Liu, Aiwei Bi, Yue-hong Chen, X. Gai, Yichen Duan, Ying Zheng, Yixian Fu, Yize Li, L. Yuan, Lin-jiang Tong, Kun Mo, Mingchen Wang, Shu-hai Lin, Minjia Tan, Chengyao Luo, Yi Chen, Jia Liu, Qiansen Zhang, Leping Li, Min Huang   +35 more
semanticscholar   +1 more source

Effect of NPM1 Mutation Subtype and Co‐Mutation Patterns on the Outcomes of Acute Myeloid Leukemia

European Journal of Haematology, Volume 115, Issue 1, Page 29-35, July 2025.
ABSTRACT Introduction NPM1 mutated AML without FLT3‐ITD is considered “favorable” per the recent ELN 2022 criteria. However, our center has been challenged with treatment‐refractory patients, prompting a search for additional prognostic factors. Methods We reviewed records of NPM1 AML patients from 2015 to 2024.
Kittika Poonsombudlert, Ratdanai Yodsuwan, Sarah Mott, Kathryn Crawford, Sarah Hornberg, Anthony N. Snow, Grerk Sutamtewagul, Margarida Magalhaes‐Silverman, Prajwal Dhakal   +8 more
wiley   +1 more source

Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples

Diagnostic Pathology
IDH1 and IDH2 mutational status is a critical biomarker with diagnostic, prognostic, and treatment implications in glioma. Although IDH1 p.R132H-specific immunohistochemistry is available, it is unable to identify other mutations in IDH1/2.
James P. Solomon, Carlos Munoz-Zuluaga, Cheyanne Slocum, Alicia Dillard, Lin Cong, Jiajing Wang, Neal Lindeman, Michael Kluk, Benjamin Liechty, David Pisapia, Hanna Rennert, Priya D. Velu   +11 more
doaj   +1 more source

Clinicopathologic Characteristics and Prognostic Profile of Chronic Myeloid Neoplasms With Somatic NF1 Mutations in Adult Patients

European Journal of Haematology, Volume 115, Issue 1, Page 46-56, July 2025.
ABSTRACT Objectives The clinicopathologic and prognostic features of somatic NF1 mutations have been well studied in pediatric myeloid neoplasms and adult acute myeloid leukemia (AML) but not in adult chronic myeloid neoplasms (CMNs), including myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs), and myelodysplastic/myeloproliferative ...
Hamza Tariq, Margarita Loxas, Mir B. Alikhan, Juehua Gao, Xinyan Lu, Qing Ching Chen, Yi‐Hua Chen, Jessica K. Altman, Lawrence J. Jennings, Madina Sukhanova   +9 more
wiley   +1 more source

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function [PDF]

, 2012
Masato Sasaki, Christiane B. Knobbe‐Thomsen, Momoe Itsumi, Andrew Elia, Isaac S. Harris, Iok In Christine Chio, Rob A. Cairns, Susan McCracken, Andrew Wakeham, Jillian Haight, Annick You Ten, Bryan E. Snow, Takeshi Ueda, Satoshi Inoue, Kazuo Yamamoto, Myunggon Ko, Anjana Rao, Katharine Yen, Shinsan M. Su, Tak W. Mak   +19 more
openalex   +1 more source