Results 211 to 220 of about 63,359 (335)

IDH1 Mutation in Gliomas in Mosul City - Iraq

Open Access Macedonian Journal of Medical Sciences, 2015
BACKGROUND: IDH1 (isocitrate dehydrogenase 1) mutation might be encounter in the low grade glioma and directs the progression of the tumor to a higher grade.OBJECTIVE: To assess the frequency of IDH1 mutations in gliomas and to correlate the IDH1 positivity with the type and grade of tumors, the age and sex of the patients.MATERIAL AND METHODS: A ...
openaire   +5 more sources

Antiseizure medication choice in diffuse glioma: A single‐center population‐based experience

Epilepsia Open, Volume 10, Issue 3, Page 705-716, June 2025.
Abstract Objective Several antiseizure medications (ASMs) can be considered as first‐line treatment for glioma‐associated epilepsy (GAE). We aimed to find out, if there are subgroups of glioma patients which may benefit from different first‐line ASMs. Methods All diffuse glioma (grade 2–4) patients, who were in contact with Helsinki University Hospital
Leena Ollila, Reina Roivainen
wiley   +1 more source

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

Cancer Cell, 2010
M. Figueroa, O. Abdel-Wahab, Chao Lu, P. Ward, Jay L. Patel, A. Shih, Yushan Li, Neha Bhagwat, A. Vasanthakumar, H. Fernandez, M. Tallman, Zhuoxin Sun, K. Wolniak, J. Peeters, Wei Liu, S. Choe, V. Fantin, E. Paietta, B. Löwenberg, J. Licht, L. Godley, R. Delwel, P. Valk, C. Thompson, R. Levine, A. Melnick   +25 more
semanticscholar   +1 more source

Biostructural, biochemical and biophysical studies of mutant IDH1

Nature Communications
We report bio-structural, bio-chemical and bio-physical evidence demonstrating how small molecules can bind to both wild-type and mutant IDH1, but only inhibit the enzymatic activity of the mutant isoform.
Mark A. McCoy, Jun Lu, F. Richard Miller, Stephen M. Soisson, Michael H. Lam, Christian Fischer   +5 more
doaj   +1 more source

Serum 2-Hydroxyglutarate Production in IDH1- and IDH2-Mutated De Novo Acute Myeloid Leukemia: A Study by the Acute Leukemia French Association Group [PDF]

, 2013
Maxime Janin, Elena Mylonas, Véronique Saada, Jean‐Baptiste Micol, Aline Renneville, Cyril Quivoron, Serge Koscielny, Laurianne Scourzic, Sébastien Forget, Cécile Pautas, Denis Caillot, Claude Preudhomme, Hervé Dombret, Céline Berthon, Robert Barouki, Daniel Rabier, Nathalie Auger, Frank Griscelli, Élisabeth Chachaty, Edwige Leclercq, Marie-Hélène Courtier, Annelise Bennaceur‐Griscelli, Éric Solary, Olivier Bernard, Virginie Penard‐Lacronique, Chris Ottolenghi, Stéphane de Botton   +26 more
openalex   +1 more source

Diagnostic and prognostic value of IDH1 mutation in gliomas

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective To discuss the significance of IDH1 mutation for diagnosis and prognosis of gliomas through detecting of IDH1 mutation in supratentorial glioma cells.
Yan⁃wu YANG, Fei XIE, Jun⁃jia TANG, Shuang LIU, Xiang WANG, Yan⁃hui LIU, Qing MAO   +6 more
doaj  

IDH1 and IDH2 mutations in pediatric acute leukemia

, 2011
Anna Andersson, D. W. Miller, Julie A. Lynch, Andrew Lemoff, Zhongling Cai, Stanley Pounds, Ina Radtke, Bing Yan, John D. Schuetz, Jeffrey E. Rubnitz, Raul C. Ribeiro, Susana C. Raimondi, J Zhang, Charles G. Mullighan, SA Shurtleff, Brenda A. Schulman, J R Downing   +16 more
openalex   +2 more sources

Clonal Hematopoiesis: Impact on Health and Disease

Hematological Oncology, Volume 43, Issue S2, June 2025.
ABSTRACT The expansion of hematopoietic cell clones, carrying alterations in genes frequently mutated in hematologic malignancies, in the absence of altered hematopoietic cell counts or otherwise defined disease criteria, is termed clonal hematopoiesis (CH). CH is frequently detectable in aged individuals and associates with numerous detrimental health
Francisco Caiado, Markus G. Manz
wiley   +1 more source

Sequencing IDH1/2 glioma mutation hotspots in gliomas and malignant peripheral nerve sheath tumors [PDF]

, 2013
Annette Bentsen Håvik, Guro E. Lind, Hilde Honne, Torstein R. Meling, David Scheie, Kirsten Sundby Hall, Eva van den Berg, Fredrik Mertens, Piero Picci, Ragnhild A. Lothe, Sverre Heim, Petter Brandal   +11 more
openalex   +1 more source

Nanotechnology in brain cancer treatment: The role of gold nanoparticles as therapeutic enhancers

Ibrain, Volume 11, Issue 2, Page 119-145, Summer 2025.
This review highlights the potential of gold nanoparticles (AuNPs) in overcoming the blood‐brain barrier (BBB) to improve brain tumor treatment. By enabling targeted drug delivery and enhancing therapies like radiotherapy, phototherapy, and chemotherapy, AuNPs offer a promising approach for safer, more effective treatments of glioblastoma and other ...
Simona Tarantino, Annalisa Bianco, Valeria De Matteis, Edoardo Scarpa, Rosaria Rinaldi   +4 more
wiley   +1 more source