Results 71 to 80 of about 1,385 (194)

Concurrent idiopathic multicentric Castleman disease with TAFRO and Sjögren’s syndrome in a young patient: a challenging diagnostic overlap

European Journal of Case Reports in Internal Medicine
Background: Idiopathic multicentric Castleman disease (iMCD) with TAFRO syndrome (characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis/renal failure, organomegaly) is a recently described disorder. The diagnostic criteria for iMCD-TAFRO
Maria Carolina Carvalho, Matilde Coimbra, João Fernandes Serodio, José Delgado Alves   +3 more
doaj   +1 more source

Transcriptome analysis of the cytokine storm-related genes among the subtypes of idiopathic multicentric Castleman disease [PDF]

Idiopathic multicentric Castleman disease (iMCD) is a type of Castleman disease unrelated to the Kaposi sarcoma-associated herpesvirus/human herpesvirus type 8 (KSHV/HHV8) infection.
Chijimatsu, Ryota, Ennishi, Daisuke, Haratake, Tomoka, Kawahara, Yuri, Lai, You Cheng, Momose, Shuji, Nakamura, Naoya, Nishikori, Asami, Nishimura, Midori Filiz, Ochi, Sayaka, Sato, Yasuharu, Takeda, Yudai, Tomida, Shuta, Ueta, Himawari   +13 more
core   +1 more source

Case report: A case of acute exacerbation of interstitial pneumonia associated with TAFRO syndrome [PDF]

, 2023
Cytokine storm caused by the overproduction of inflammatory interleukin (IL)-6 plays a central role in the development of acute inflammation. The extremely rare disease, TAFRO syndrome, progresses quickly.
Eri Shishido, Hiroaki Yokomori, Hiroyuki Okawa, Kaori Ehara, Mako Fujino, Shinya Okada, Yasushi Nagaba, Yoshitaka Shimada   +7 more
core   +1 more source

Serum Soluble Interleukin-2 Receptor as a Potential Marker for Assessing Disease Activity in the TAFRO Subtype of Idiopathic Multicentric Castleman Disease. [PDF]

Intern Med
Idiopathic multicentric Castleman disease (iMCD) accompanied by thrombocytopenia, anasarca, fever, reticulin myelofibrosis/renal insufficiency, and organomegaly (TAFRO) frequently develops into prolonged severe thrombocytopenia and multiorgan dysfunction,
Ozaki T, Imada C, Shirakami K, Abe T, Shingai Y, Umeki T, Fukuda A, Ishii K, Shibata H.   +8 more
europepmc   +2 more sources

A Review of Genetic Abnormalities in Unicentric and Multicentric Castleman Disease

Biology, 2021
Castleman disease (CD) is a rare lymphoproliferative disorder known to represent at least four distinct clinicopathologic subtypes. Large advancements in our clinical and histopathologic description of these diverse diseases have been made, resulting in ...
Alexandra Butzmann, Jyoti Kumar, Kaushik Sridhar, Sumanth Gollapudi, Robert S. Ohgami   +4 more
doaj   +1 more source

A Placebo-Controlled Exploratory Trial of Sirolimus for Tocilizumab-Resistant Idiopathic Multicentric Castleman Disease: Early Termination and Long-Term Extension Results Based on Descriptive Results From Two Patients. [PDF]

Cureus
Background Idiopathic multicentric Castleman disease (iMCD) remains challenging to treat, with a considerable number of patients showing insufficient response to tocilizumab, the current standard therapy for iMCD.
Koga T, Sumiyoshi R, Shimizu T, Hosogaya N, Fukushima C, Yamamoto H, Yoshifuji H, Higa S, Kawakami A.   +8 more
europepmc   +2 more sources

Use of tocilizumab to treat IgA nephropathy complicated by idiopathic multicentric Castleman disease: a case report. [PDF]

BMC Nephrol
Idiopathic multicentric Castleman disease (iMCD) is a rare polyclonal lymphoproliferative disorder characterised by excessive interleukin-6 (IL-6) production.
Komeno Y, Usui T, Inoue K, Nakajima K, Harada T, Shimizu T, Tsunoda R, Morito N, Mase K, Usui J, Saito C, Kawanishi K, Yamagata K.   +12 more
europepmc   +2 more sources

Efficacy of High‐Dose Intravenous Anakinra in Pediatric TAFRO Syndrome: Report of Two Cases and Literature Review

Pediatric Blood &Cancer, Volume 72, Issue 8, August 2025.
ABSTRACT TAFRO (thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly) syndrome is a rare, life‐threatening inflammatory condition linked to infections, neoplasms, and idiopathic multicentric Castleman disease. Interleukin (IL)‐6 inhibitors are the primary treatment, but refractory cases require alternatives. This
Serena Palmeri, Jacopo Ferro, Valentina Natoli, Caterina Matucci‐Cerinic, Riccardo Papa, Silvia Rosina, Stefania Sorrentino, Stefano Volpi, Valerio Gaetano Vellone, Marco Gattorno, Roberta Caorsi   +10 more
wiley   +1 more source

Dichotomic response to interleukin-6 blockade in idiopathic multicentric Castleman disease: two case reports

Journal of Medical Case Reports, 2021
Background Human herpervirus-8/human immunodeficiency virus negative Idiopathic multicentric Castleman disease (iMCD) is a lymphoproliferative disorder sustained by a pro-inflammatory condition of hypercytokinemia mostly mediated by Interleukin-6 (IL-6).
Simone Ferrero, Simone Ragaini
doaj   +1 more source

Computed tomography findings of idiopathic multicentric Castleman disease subtypes [PDF]

This study retrospectively evaluated the computed tomography (CT) findings of idiopathic multicentric Castleman disease (iMCD) at a single center and compared the CT findings of iMCD-TAFRO with those of iMCD-non-TAFRO.
Asahara, Takashi, Hiraki, Takao, Iguchi, Toshihiro, Iwaki, Noriko, Kojima, Katsuhide, Maeda, Yoshinobu, Nishikori, Asami, Nishimura, Midori Filiz, Otsuka, Fumio, Sato, Yasuharu   +9 more
core   +1 more source