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Identifying potential biomarkers of idiopathic pulmonary fibrosis through machine learning analysis

open access: yesScientific Reports, 2023
Idiopathic pulmonary fibrosis (IPF) is the most common and serious type of idiopathic interstitial pneumonia, characterized by chronic, progressive, and low survival rates, while unknown disease etiology.
Zenan Wu   +7 more
doaj   +2 more sources

Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes?

open access: yesFrontiers in Immunology, 2021
The immune system is receiving increasing attention for interstitial lung diseases, as knowledge on its role in fibrosis development and response to therapies is expanding. Uncontrolled immune responses and unbalanced injury-inflammation-repair processes
Chiel van Geffen   +10 more
doaj   +2 more sources

Idiopathic pulmonary fibrosis: current diagnosis and treatment [PDF]

open access: yesJornal Brasileiro de Pneumologia, 2023
Idiopathic pulmonary fibrosis (IPF) is a devastating chronic lung disease without a clear recognizable cause. IPF has been at the forefront of new diagnostic algorithms and treatment developments that led to a shift in patients’ care in the past decade ...
Alexandre Franco Amaral   +2 more
doaj   +1 more source

Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline

open access: yesAmerican Journal of Respiratory and Critical Care Medicine, 2022
Background This American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and Asociación Latinoamericana de Tórax guideline updates prior idiopathic pulmonary fibrosis (IPF) guidelines and addresses the progression of ...
G. Raghu   +40 more
semanticscholar   +1 more source

Global incidence and prevalence of idiopathic pulmonary fibrosis

open access: yesRespiratory Research, 2021
Background Idiopathic pulmonary fibrosis (IPF) is a progressive debilitating lung disease with considerable morbidity. Heterogeneity in epidemiologic studies means the full impact of the disease is unclear.
T. Maher   +7 more
semanticscholar   +1 more source

IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis.

open access: yesPLoS ONE, 2021
Idiopathic pulmonary fibrosis is a chronic, fibrosing interstitial pneumonia that presents with various clinical courses and progression ranging from rapid to slow.
Yu Nakanishi   +11 more
doaj   +1 more source

Efficacy of Pirfenidone and Nintedanib in Interstitial Lung Diseases Other than Idiopathic Pulmonary Fibrosis: A Systematic Review

open access: yesInternational Journal of Molecular Sciences, 2023
Pirfenidone and nintedanib are antifibrotic medications approved for idiopathic pulmonary fibrosis treatment by regulatory agencies and available for clinical use worldwide.
F. Amati   +6 more
semanticscholar   +1 more source

Impact of the new definition for pulmonary hypertension in patients with lung disease: an analysis of the United Network for Organ Sharing database

open access: yesPulmonary Circulation, 2021
The implications of the recent change in the definition of pulmonary hypertension on epidemiology and outcomes are not known. We sought to determine the percentage of patients with the two most common lung diseases that would be reclassified regarding ...
Steven D. Nathan   +7 more
doaj   +1 more source

Clinical relevance of circulating autoantibodies in idiopathic pulmonary fibrosis; A NAt hard to break

open access: yesFrontiers in Medicine, 2022
Patients with idiopathic pulmonary fibrosis are screened for circulating autoantibodies as part of the initial interstitial lung disease workup. Management of seropositive idiopathic pulmonary fibrosis is currently considered no different than that of ...
Paraskevi Kirgou   +8 more
doaj   +1 more source

The Role of DNA Damage and Repair in Idiopathic Pulmonary Fibrosis

open access: yesAntioxidants, 2022
The mortality rate of idiopathic pulmonary fibrosis (IPF) increases yearly due to ineffective treatment. Given that the lung is exposed to the external environment, it is likely that oxidative stress, especially the stimulation of DNA, would be of ...
Jiahui Zhu   +10 more
doaj   +1 more source

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