Results 101 to 110 of about 106,594 (302)

First report of multinodular pulmonary fibrosis associated with equine herpesvirus 5 in Belgium [PDF]

, 2010
A 20-year-old horse was evaluated for symptoms of weight loss, anorexia, fever and lethargy. Clinical examination revealed tachypnea, poor body condition and increased breath sounds on auscultation. Ultrasound showed multiple consolidations on the lungs.
Borchers, K, Deprez, Piet, Ducatelle, Richard, Maes, S, Saey, Veronique, Van de Walle, Gerlinde, Verryken, Kirsten   +6 more
core  

The 6 minute walk in idiopathic pulmonary fibrosis: longitudinal changes and minimum important difference [PDF]

, 2010
The response characteristics of the 6 minute walk test (6MWT) in studies of idiopathic pulmonary fibrosis (IPF) are only poorly understood, and the change in walk distance that constitutes the minimum important difference (MID) over time is ...
Behr, Jürgen, Brown, Kevin K., du Bois, Roland M., King, Talmadge E., Raghu, Ganesh, Swigris, Jeffrey J., Wamboldt, Frederick S.   +6 more
core   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution. [PDF]

, 2017
Thy-1-negative lung fibroblasts are resistant to apoptosis. The mechanisms governing this process and its relevance to fibrotic remodeling remain poorly understood. By using either sorted or transfected lung fibroblasts, we found that Thy-1 expression is
Bradley, John E, Espinoza, Celia R, Finley, J Cameron, Hagood, James S, Head, Brian P, Kim, Jeeyeon, Liu, Xiaoqiu, Mah, Emma J, Patel, Hemal H, Shentu, Tzu-Pin, Taype, Carmen A, Wong, Simon S   +11 more
core   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Diagnostic test interpretation and referral delay in patients with interstitial lung disease. [PDF]

, 2019
BACKGROUND:Diagnostic delays are common in patients with interstitial lung disease (ILD). A substantial percentage of patients experience a diagnostic delay in the primary care setting, but the factors underpinning this observation remain unclear.
Adegunsoye, Ayodeji, Boctor, Noelle, Chung, Jonathan H, DiGeronimo, Ryan, Kadoch, Michael, Lafond, Elyse, Oldham, Justin M, Pan, Isabella, Pritchard, David, Pugashetti, Janelle Vu, Sarma, Nandini, Strek, Mary   +11 more
core   +1 more source

Mindfulness-based stress reduction in patients with interstitial lung diseases: a pilot, single-centre observational study on safety and efficacy [PDF]

, 2015
open11siBackground Chronic, progressive respiratory symptoms are associated with great psychological and emotional impact in patients suffering from interstitial lung disease (ILD).
CERRI, Stefania, FERRARI, ROBERTO, Garuti, Martina, LUPPI, Fabrizio, MONTANARI, GLORIA, Ori, Margherita, Petropulacos, Kyriakoula, Poletti, Stefano, Ricchieri, Maria Pia, RICHELDI, Luca, SGALLA, Giacomo   +10 more
core   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Diffuse pulmonary ossification associated with fibrosing interstitial lung disease

Respiratory Medicine Case Reports, 2019
Diffuse pulmonary ossification (DPO) is a rare condition that presents with metaplastic mature bone formation in the pulmonary parenchyma. DPO is usually associated with cardiovascular or respiratory disease.
Badreeddine Alami, Bouchra Amara, Meryem Haloua, Moulay Youssef Alaoui Lmrani, Mounia Serraj, Meryem Boubou, Mustapha Maaroufi   +6 more
doaj   +1 more source

Interstitial Lung Disease in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: A European Multicenter Study

Arthritis &Rheumatology, EarlyView.
Objective Interstitial lung disease (ILD) can occur in association with antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV‐ILD) or as an isolated entity with positive ANCA (ANCA‐ILD). However, data on the epidemiology and outcomes of these conditions remain limited.
Aglaia Chalkia, Marusa Kotnik, Timothy J. Sadler, Spyridon Katechis, Rachel Jones, Ajay Kamath, Aladdin J. Mohammad, Sara Monti, Chetan Mukhtyar, Viral Nanda, Ioannis Petrakis, Dimitrios Petras, Ashnish Sinha, Pasupathy Sivasothy, Rona Smith, Kostas Stylianou, Dimitrios Vassilopoulos, Judith Babar, David Jayne   +18 more
wiley   +1 more source