Results 111 to 120 of about 1,177,456 (242)
iNew Medicine, EarlyView.Therapeutic mechanism, clinical efficacy and future directions for nerandomilast in pulmonary fibrosis. ABSTRACT The recent Phase III FIBRONEER trials establish nerandomilast, a novel oral phosphodiesterase 4B (PDE4B) inhibitor, as an effective therapy for idiopathic and progressive pulmonary fibrosis. By elevating cyclic adenosine monophosphate (cAMP),
Qianwen Bai +4 more
wiley +1 more source
Mitigation of Oxidative Stress in Idiopathic Pulmonary Fibrosis Through Exosome-Mediated Therapies [PDF]
Zaiyan Wang,1 Yuan Zhang,2 Xiaoning Li3 1Department of Pulmonary and Critical Care Medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, 201318, People’s Republic of China; 2Department of Pulmonary and Critical
Li X, Zhang Y, Wang Z
core
Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis: A New Phenotype?
, 2014 Redondo M, Costa D, Melo N, Mota P, Morais A. Pulmonary Hypertension in Idiopathic Pulmonary Fibrosis: A New Phenotype? Chest.
Costa, Diogo ; https://orcid.org/ +4 more
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Metrnl: A Novel Therapeutic Target in Atherosclerosis
iNew Medicine, EarlyView.ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source
Mechanical memory in aging: From adaptive sensing to pathological entrenchment
Interdisciplinary Medicine, EarlyView.Mechanical memory in aging operates through four temporal tiers, from cytoskeletal remodeling to metabolic reprogramming. Aging disrupts this cascade through three distinct decoupling patterns: sensor degradation, conduction blockade, and execution failure, leading to irreversible pathological entrenchment across multiple organ systems.
Mingyang Huang +7 more
wiley +1 more source
Nail Lichen Planus in Children ‐ Epidemiology, Pathogenesis, Clinical Presentation, and Treatment
JEADV Clinical Practice, EarlyView.ABSTRACT Nail lichen planus (NLP) is a chronic inflammatory disorder that, while rare in children compared to adults, represents a significant cause of pediatric nail dystrophy that requires early recognition to prevent permanent scarring and nail loss.
Francesca Pampaloni, Matilde Iorizzo
wiley +1 more source
Evaluating the Local Response of a Novel Injectable Capsule for Drug Delivery in the Trachea
The Laryngoscope, EarlyView.A novel PLGA polymer capsule was developed for localized pretracheal drug delivery and evaluated for short‐term local tissue safety in a rabbit model. Implant placement was confirmed by ultrasound and was well tolerated over 14 days, with preservation of airway patency, native tracheal architecture, and biomechanical properties.
Denzel Ryan D. Cruz +7 more
wiley +1 more source
Nintedanib for treating idiopathic pulmonary fibrosis
, 2015 To appraise the clinical and cost effectiveness of nintedanib within its licensed indication for treating idiopathic pulmonary ...
Streit, Elke +6 more
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Therapeutic JAK Inhibition in Idiopathic Subglottic Stenosis
The Laryngoscope, EarlyView.Three patients with idiopathic subglottic stenosis and rheumatoid arthritis began JAK inhibitor therapy, after which the mean surgical‐free interval between endoscopic dilations rose from 317 to 631 days and the annualized dilation rate fell from 1.24 to 0.38 per patient‐year. Figure 2 shows this as a per‐patient timeline.
Riley M. Larkin +5 more
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Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
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