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Epigenetics in idiopathic pulmonary fibrosis
Biochemistry and Cell Biology, 2015Idiopathic pulmonary fibrosis (IPF) is a lethal chronic lung disorder with no effective treatment and a prognosis worse than that of lung cancer. Despite extensive research efforts, its etiology and pathogenesis still remain largely unknown. Current experimental evidence has shifted the disease paradigm from chronic inflammation towards the premise of
Argyrios, Tzouvelekis, Naftali, Kaminski
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Familial Idiopathic Pulmonary Fibrosis
2013Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease of unknown etiology, with an appearance of usual interstitial pneumonia on lung biopsy. To-date, about a 100 families diagnosed with IPF have been described. Familial IPF is defined as histologically confirmed IPF occurring in two or more members of a family.
K, Wytrychowski +2 more
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Treatments for Idiopathic Pulmonary Fibrosis
New England Journal of Medicine, 2014To the Editor: In reporting the results of the INPULSIS-1 and INPULSIS-2 trials, Richeldi et al. (May 29 issue) 1 describe the use of nintedanib in the treatment of idiopathic pulmonary fibrosis. In the same issue, King et al. 2 report the results of the Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis (ASCEND ...
Shinyu, Izumi +2 more
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Idiopathic pulmonary fibrosis in infants
Pediatric Pulmonology, 1997Idiopathic pulmonary fibrosis is a poorly characterized disease in infants. In the present report, we reviewed our experience with 10 infants during a 10-year period. In 9 patients, onset of symptoms occurred before the age of 2 months and included tachypnea, cough, and inadequate weight gain.
E, Osika +8 more
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MicroRNAs in idiopathic pulmonary fibrosis
Translational Research, 2011In this review, we describe the recent advances in the understanding of the role of microRNAs in idiopathic pulmonary fibrosis (IPF), a chronic progressive and lethal fibrotic lung disease. Approximately 10% of the microRNAs are significantly changed in IPF lungs.
Kusum V, Pandit +2 more
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MUC5B and Idiopathic Pulmonary Fibrosis
Annals of the American Thoracic Society, 2015Abstract Idiopathic pulmonary fibrosis (IPF), a fatal disease that is a result of complex interactions between genetics and the environment, has limited treatment options. We have identified the MUC5B promoter polymorphism and other common genetic variants that in aggregate explain roughly one-third of disease risk. The MUC5B promoter
Ivana V, Yang +4 more
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Pulmonary rehabilitation in idiopathic pulmonary fibrosis
Current Opinion in Pulmonary MedicinePurpose of review This review synthesizes the expanding evidence for pulmonary rehabilitation that has led to its recommended inclusion in the holistic care of people with idiopathic pulmonary fibrosis (IPF), as well as discussing strategies that may maximize and sustain benefits.
Leona M, Dowman, Anne E, Holland
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Imaging of Idiopathic Pulmonary Fibrosis
Radiologic Clinics of North America, 2016Idiopathic interstitial pneumonias are a heterogeneous group of diffuse lung diseases characterized by distinct clinicopathologic entities with the usual interstitial pneumonia (UIP) being the most common. The pattern of UIP can be seen in idiopathic pulmonary fibrosis (IPF) as well as in secondary causes, most commonly in connective tissue diseases ...
Joanna E, Kusmirek +2 more
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