Results 251 to 260 of about 999,769 (295)

Consensus palliative care referral criteria for people with idiopathic pulmonary fibrosis: an international Delphi study. [PDF]

Ann Am Thorac Soc
Pascoe A, Smallwood N, Philip J, Chang YK, Bajwah S, Ekström M, Goh N, Khor YH, Leng M, Lindell KO, Lindell KO, McCulloch J, Pérez-Cruz PE, Warwick T, Hui D.   +14 more
europepmc   +1 more source

Transmembrane Protein PTCHD4 Is a Novel Regulator of Cellular Senescence and Age‐Related Pathologies

Aging Cell, Volume 25, Issue 9, September 2026.
PTCHD4 is induced by aging‐ and injury‐associated stresses and acts as a senescence‐associated transmembrane regulator. Through AKT activation, PTCHD4 promotes cellular senescence, SASP, functional decline, and pulmonary fibrosis, whereas PTCHD4 deficiency dampens AKT signaling and alleviates senescence‐associated pathological phenotypes.
Mingyue Wang, Zhaoyun Yang, Qikai Wang, Zeping Li, Zhihua Huang, Le Wang, Xiaoning Sun, Donglin Yu, Wenhua Yu, Xiaoxia Bao, Zebin Mao, Yang Li   +11 more
wiley   +1 more source

Multi-omics integration identifies APOE as a metabolic regulator of macrophage-fibroblast crosstalk in idiopathic pulmonary fibrosis. [PDF]

Front Immunol
Bai B, Chang L, Cheng Z, Wang Y, Hua C, Feng Y, Zhao W.   +6 more
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Milos Jesenak, Francesca Levi‐Schaffer, Giuseppe Nocentini, Liam O'Mahony, Oscar Palomares, Frank Redegeld, Milena Sokolowska, Betty Van Esch, Marco Zurlo, Cristiana Stellato   +20 more
wiley   +1 more source

Relationship of prognostic nutritional index with clinical outcomes and survival in idiopathic pulmonary fibrosis. [PDF]

BMC Pulm Med
Guler N, Alpaydin AO, Tertemiz KC, Sevinc C, Ellidokuz H, Simsek GO, Ucan ES.   +6 more
europepmc   +1 more source

Clinical Features of Cellular Senescence Pathways in Severe Asthma

Allergy, Volume 81, Issue 9, Page 3273-3285, September 2026.
In bronchial biopsies, SASP and p53 pathway enrichment scores are elevated in severe asthma versus non‐severe asthma and healthy controls. SASP enrichment is validated in the independent NOVA cohort. SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status.
Woo‐Jung Song, Nazanin Zounemat Kermani, Ali Versi, Stephany Sánchez‐Ovando, Jodie Louise Simpson, Peter A. Wark, Katherine Joanne Baines, Sven‐Erik Dahlén, Ratko Djukanovic, Yike Guo, Ian M. Adcock, Kian Fan Chung, on behalf of the U‐BIOPRED Study Group, Mahmoud. I. Abdel‐Aziz, Ian M. Adcock, Lars I. Andersson, Charles Auffray, Yusef E. Badi, Per Bakke, Aruna T. Bansal, Frederic Baribaud, Stewart A. Bates, Elisabeth H. Bel, Jeanette Bigler, Bo Billing, Hans Bisgaard, Michael J. Boedigheimer, Klaus Bønnelykke, Joost Brandsma, Paul Brinkman, Enrica Bucchioni, Dominic Burg, Andrew Bush, Massimo Caruso, Romanas Chaleckis, Pascal Chanez, Kian Fan Chung, T. Checa, Chris H. Compton, Julie Corfield, Danen Cunoosamy, Arnaldo D'Amico, Barbro Dahlén, Sven‐Erik Dahlén, Bertrand De Meulder, Ratko Djukanovic, Veit J. Erpenbeck, Damijan Erzen, K. Fichtner, Louise J. Fleming, Elena Formaggio, Stephen J. Fowler, Urs Frey, Martina Gahlemann, Thomas Geiser, Victoria Goss, Yike Guo, Simone Hashimoto, John Haughney, Gunilla Hedlin, Pieter‐Paul W. Hekking, Timothy Higenbottam, Jens M. Hohlfeld, Cecile Holweg, Ildiko Horvath, Peter Howarth, Anna J. James, Richard G. Knowles, Johan Kolmert, Jon Konradsen, Norbert Krug, Nikos Lazarinis, C.‐X. Li, Matthew J. Loza, Rene Lutter, Alexander Manta, Sarah Masefield, Anke H. Maitland‐van der Zee, John G. Matthews, Alexander Mazein, Roelinde J. M. Middelveld, Montserrat Miralpeix, Paolo Montuschi, Jacek Musial, Sharon Mumby, David Myles, Björn Nordlund, Ioannis Pandis, Stelios Pavlidis, Anthony Postle, P. Powel, G. Praticò, M. Puig Valls, N. Rao, Stacey Reinke, John Riley, Amanda Roberts, Graham Roberts, Anthony Rowe, Thomas Sandström, Jim P. R. Schofield, Wolfgang Seibold, Dominic E. Shaw, R. Sigmund, Florian Singer, Paul J. Skipp, M. Smicker, Ana R. Sousa, Maria Sparreman‐Mikus, Peter J. Sterk, Marika Ström, Kai Sun, Bob Thornton, Mohib Uddin, Ali Versi, Jorgen Vestbo, Nadja H. Vissing, Scott S. Wagers, Åsa Wheelock, Craig E. Wheelock, Susan J. Wilson, Valentyna Yasinska, Nazanin Zounemat Kermani   +122 more
wiley   +1 more source

Carotid Intima-Media Thickness and Atherogenic Indices in Idiopathic Pulmonary Fibrosis: Evidence of Subclinical Atherosclerosis. [PDF]

Life (Basel)
Balci A, Inkaya Y, Sen S.
europepmc   +1 more source

TRPA1 Regulates Fibrosis‐Associated Transcriptional Pathways in Human Lung Epithelial Cells

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Leevi Halonen, Samu Luostarinen, Ida Valjus, Julia Vistbacka, Antti Pemmari, Eeva Moilanen   +5 more
wiley   +1 more source