Results 291 to 300 of about 95,044 (332)

Single Cell RNA-Seq Identifies Cell Subpopulations Contributing to Idiopathic Pulmonary Fibrosis in Humans. [PDF]

J Cell Mol Med
Zhang T, Hou Z, Ding Z, Wang P, Pan X, Li X.   +5 more
europepmc   +1 more source

Evaluation of Interstitial Lung Disease Complications Caused by Biologic Agents Using a Spontaneous Adverse Drug Reaction Reporting Database

Pharmacology Research &Perspectives, Volume 13, Issue 2, April 2025.
ABSTRACT Interstitial lung disease (ILD) is a clinically relevant adverse event associated with biologic agent use. However, the current incidence of ILD remains unclear as large‐scale risk assessments of biologic agents have not been conducted. The aim of this study was to clarify the association between biologic agent use and ILD development in ...
Ayu Minagi, Hideki Nawa, Mitsuhiro Goda, Takahiro Niimura, Koji Miyata, Hirofumi Hamano, Yoshito Zamami, Keisuke Ishizawa   +7 more
wiley   +1 more source

Could Hepcidin Be a New Biomarker in Patients with Idiopathic Pulmonary Fibrosis (IPF)? [PDF]

J Clin Med
Yilmaz G, Çoban H, Sarioglu N, Erel F, Yılmaz MA, Çolak M, Yumrukuz Şenel M, Hismioğulları AA.   +7 more
europepmc   +1 more source

Cellular Communication Network Protein 2 in the Right Ventricle of Pulmonary Arterial Hypertension

Pulmonary Circulation, Volume 15, Issue 2, April 2025.
ABSTRACT Cellular communication network 2 (CCN2) is a secreted matricellular protein associated with pulmonary arterial hypertension (PAH) but has not been studied relative to PAH severity, outcomes, or right ventricle (RV) structure and function in a large human cohort and preclinical animal model. This study assessed the associations between CCN2 and
Carly E. Byrd, Jennifer E. Schramm, Jun Yang, Allan E. Barnes, Megan Griffiths, Anjira S. Ambade, Darin T. Rosen, Ilton M. Cubero Salazar, Catherine E. Simpson, Ryan J. Tedford, Steven Hsu, Dhananjay Vaidya, Todd M. Kolb, Michael W. Pauciulo, William C. Nichols, David D. Ivy, Eric D. Austin, Paul M. Hassoun, Rachel L. Damico, Allen D. Everett   +19 more
wiley   +1 more source

Tissue-resident Klebsiella quasipneumoniae contributes to progression of idiopathic pulmonary fibrosis by triggering macrophages mitophagy in mice. [PDF]

Cell Death Discov
Xu C, Sun P, Jiang Q, Meng Y, Dong L, Wang X, Hu X, Li C, Li G, Zheng R, You X, Yang X.   +11 more
europepmc   +1 more source

A Prospective Analysis of Vasoreactivity and Mortality in WHO Group 3 Pulmonary Hypertension

Pulmonary Circulation, Volume 15, Issue 2, April 2025.
ABSTRACT Prognostic markers of Group 3 pulmonary hypertension (PH) remain largely unknown. In this study, we evaluate clinical data to provide a comprehensive profile of patients with Group 3 PH and evaluate the potential use of vasoreactivity testing as a prognostic tool within this population.
Daniel J. Strick, Carl Tanba, Meredith A. Kaplan, Nicholas S. Hill, Harrison W. Farber, David Condon, Ioana R. Preston   +6 more
wiley   +1 more source

Mas1 Receptor Activation is Necessary and Sufficient to Transduce ACE2 Effect in PAH, But Ang(1‐7) Alone is Insufficient

Pulmonary Circulation, Volume 15, Issue 2, April 2025.
ABSTRACT ACE2 has shown effectiveness in treating pulmonary hypertension in multiple animal models and has some promise in early human trials. The key barrier to translation is that enzymatically active ACE2 is difficult to manufacture and exhibits a short half‐life in humans, making chronic administration challenging.
James West, Megha Talati, Erica Carrier, Anandharajan Rathinasabapathy, Ibragim Gaidarov, Benjamin Vigl, Ying Cai, Hongpeng Jia, Tom Blackwell, Santhi Gladson, Christie Moore, Sheila Shay, Ethan Sevier, Anna Hemnes   +13 more
wiley   +1 more source

Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis. [PDF]

Front Pharmacol
Gao H, Sun Z, Hu X, Song W, Liu Y, Zou M, Zhu M, Cheng Z.   +7 more
europepmc   +1 more source

Targeting Frequent Efferocytosis in Tumor Microenvironment is a New Direction for Cancer Treatment

Small Science, Volume 5, Issue 4, April 2025.
Phagocytosis of “apoptotic tumor cells”, known as efferocytosis, accelerates the formation of an immunosuppressive microenvironment, leading to the detriment of tumor therapy. Blocking this process represents one of the novel approaches for treating tumors.
Gangxing Zhu, Xinliang Wan, Wanyin Wu, Luyu Jia, Xiaoyan Yu, Handan Mo, Xi Wang, Qichun Zhou, Qing Tang, Sumei Wang   +9 more
wiley   +1 more source

Identification and Analysis of Key Immune- and Inflammation-Related Genes in Idiopathic Pulmonary Fibrosis. [PDF]

J Inflamm Res
Tan Y, Qian B, Ma Q, Xiang K, Wang S.
europepmc   +1 more source