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Idiopathic pulmonary fibrosis (IPF) is a progressive devastating lung disease with substantial morbidity. It is associated with cough, dyspnea and impaired quality of life. If left untreated, IPF has a median survival of 3 years. IPF affects ∼3 million people worldwide, with increasing incidence in older patients. The current concept of pathogenesis is
Thomas Koudstaal, Marlies S. Wijsenbeek
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Treatment of Idiopathic Pulmonary Fibrosis [PDF]
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia of unknown cause, occurring in adults and limited to the lungs. In the past, treatment was aimed at minimizing inflammation and slowing the progression of inflammation to fibrosis. However, the underlying lesion in IPF may be more fibrotic than inflammatory,
Gregory Becker+2 more
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TGF-β1: Gentlemanly orchestrator in idiopathic pulmonary fibrosis (Review)
Idiopathic pulmonary fibrosis (IPF) is a worldwide disease characterized by the chronic and irreversible decline of lung function. Currently, there is no drug to successfully treat the disease except for lung transplantation.
Zhimin Ye, Yongbin Hu
semanticscholar +1 more source
Occurrence of idiopathic pulmonary fibrosis during immunosuppressive treatment: a case report [PDF]
Immunosuppressive therapy has been-until the recent release of new guidelines on diagnosis and management-the recommended treatment for idiopathic pulmonary fibrosis.
CERRI, Stefania+3 more
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Background In patients receiving single lung transplantation for idiopathic pulmonary fibrosis, worsening of fibrosis of the native lung is usually progressive over time, with no significant effects on gas exchange.
Tiphaine Goletto+14 more
doaj +1 more source
Comorbid Conditions in Idiopathic Pulmonary Fibrosis: Recognition and Management. [PDF]
Idiopathic pulmonary fibrosis (IPF), a fibrosing interstitial pneumonia of unknown etiology, primarily affects older adults and leads to a progressive decline in lung function and quality of life.
Collard, Harold R, Oldham, Justin M
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Growth factors in idiopathic pulmonary fibrosis: relative roles [PDF]
Treatment of idiopathic pulmonary fibrosis patients has evolved very slowly; the fundamental approach of corticosteroids alone or in combination with other immunosuppressive agents has had little impact on long-term survival.
Allen, JT, Spiteri, MA
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Is It Idiopathic Pulmonary Fibrosis or Not? [PDF]
Pulmonary fibrosis is not uncommon. Usual interstitial pneumonitis (UIP)/idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic pulmonary fibrotic diseases and has the worst prognosis with a mean life expectancy of 3.8 years.
Genta Ishikawa+2 more
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Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Adamson IY+66 more
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Multiscale modelling of reversed Potts shunt as a potential palliative treatment for suprasystemic idiopathic pulmonary artery hypertension in children [PDF]
Reversed Potts shunt (PS) was suggested as palliation for patients with suprasystemic pulmonary arterial hypertension (PAH) and right ventricular (RV) failure. PS, however, can result in poorly understood mortality. Here, a patient-specific geometrical multiscale model of PAH physiology and PS is developed for a paediatric PAH patient with stent-based ...
arxiv +1 more source