Results 61 to 70 of about 61,250 (205)

Comprehensive analysis of extracellular matrix remodelling via cyclophilin inhibition in human models of alcohol‐related liver fibrosis

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic liver disease and hepatic fibrosis constitute a threat to global health. Clinical translation of preclinical research has been limited, highlighting an urgent need for novel treatments. Cyclophilin inhibitors have shown beneficial effects in liver disease; however, the underlying mechanism of action and the effect across ...
Una Rastovic, Sara Campinoti, Lai Wei, Bruna Almeida, Sergio Francesco Bozzano, Ramin Amiri, Nicola Harris, Omolola Ajayi, Tsin Shue Koay, Caoimhe Kerins, Fiona N. Kenny, Ane Zamalloa, Lissette Adofina, Rosa Miquel, Yoh Zen, Parthi Srinivasan, Krishna Menon, Nigel Heaton, Camilla Luni, Eileen Gentleman, Tanya Shaw, Daren Ure, Shilpa Chokshi, Luca Urbani, Elena Palma   +24 more
wiley   +1 more source

Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia (UIP) [PDF]

, 2001
João Valente Barbas‐Filho
openalex   +1 more source

Beyond Carrier Status: CFTR Heterozygosity as an Overlooked Clinical Risk Factor for Pancreatitis

Clinical Genetics, EarlyView.
CFTR carrier status detected via prenatal screening is associated with increased pancreatitis risk in women, but clinical recognition remains low. Integrating carrier results into electronic health records may enhance personalized care and aid in early diagnosis. ABSTRACT This study assessed the effect of CFTR pathogenic variant status, detected during
Lucas D. Richter, Douglas M. Ruderfer, Josh F. Peterson, Lisa A. Bastarache   +3 more
wiley   +1 more source

Lung Cancer in Patients with Idiopathic Pulmonary Fibrosis.

, 1992
Atsushi Nagai, Atsushi Chiyotani, Toshio Nakadate, Kimio Konno   +3 more
openalex   +2 more sources

Upregulation of Fas-signalling molecules in lung epithelial cells from patients with idiopathic pulmonary fibrosis [PDF]

, 2001
Takuya Maeyama, Kazuyoshi Kuwano, M. Kawasaki, Ritsuko Kunitake, Naoki Hagimoto, Tokuji Matsuba, Michihiro Yoshimi, Ichiro Inoshima, Keiichi Yoshida, Nobuyuki Hara   +9 more
openalex   +1 more source

Super‐Enhancer Target Gene CBP/p300‐Interacting Transactivator With Glu/Asp‐Rich C‐Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling

Cell Proliferation, EarlyView.
During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li, Jingya Zhang, Xu Wang, Xinru Wang, Yuyu Song, Xinyue Song, Xiuli Wang, Weiwei Cao, Chong Zhao, Jing Qi, Xiaodong Zheng, Yan Xing   +11 more
wiley   +1 more source

Single lung transplantation from a brain-dead donor for a patient with idiopathic pulmonary fibrosis [PDF]

, 2001
Shinichiro Miyoshi, Masato Minami, Mitsunori Ohta, Meinoshin Okumura, Shin’ichi Takeda, Hikaru Matsuda   +5 more
openalex   +1 more source

Soluble IL‐2 receptor levels support diagnosis of sarcoidosis‐like reaction in melanoma patients on immunotherapy – a diagnostic algorithm based on a single center retrospective study

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and Objectives Drug‐induced sarcoidosis‐like reaction (DISR) is an adverse event with emerging importance during immune checkpoint inhibitor (ICI) treatment in melanoma patients. Its reported frequency varies widely, making accurate diagnosis crucial.
Philipp Gussek, Julia Mentzel, Maxime Ablefoni, Mirjana Ziemer   +3 more
wiley   +1 more source

Multi‐omic analysis identifies biological processes underlying progressive interstitial lung disease in systemic sclerosis

The FEBS Journal, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease, and lung complications (ILD) are the main cause of death. This study compared SSc patients with and without lung disease to healthy volunteers. We found increased inflammation, specific proteins, and higher triglyceride levels linked to lung disease progression. These findings suggest triglycerides
Selena Bouffette, Perrine Soret, Alice Cole, Emmanuel Nony, Pierre Barbier Saint Hilaire, Grégory Leclerc, Lamine Alaoui, Audrey Aussy, Isabelle Wehrle, Aude Le Gall, Mark Coulon, Marc Pallardy, Voon Ong, Jeanne Allinne, Philippe Moingeon, David Abraham, Christopher P. Denton   +16 more
wiley   +1 more source

Cutaneous Features of Adams‐Oliver Syndrome: Diagnosis, Differentiation, and Management

Pediatric Dermatology, EarlyView.
ABSTRACT Adams‐Oliver syndrome (AOS) is a rare genetic disorder primarily characterized by aplasia cutis congenita (ACC) and terminal transverse limb defects. The condition presents with a range of cutaneous features, most notably ACC, cutis marmorata telangiectatica congenita, and nail anomalies.
Sabrina Yang, Joseph M. Lam
wiley   +1 more source