Short-acting growth hormone supplementation for bone age and growth rate in children with idiopathic short stature: a meta-analysis. [PDF]
BMC PediatrObjective To explore the effect of short-acting growth hormone (GH) supplementation on bone age and growth rate of children with idiopathic short stature.
Yang L, Yang F.
europepmc +3 more sources
Heterozygous NPR2 Variants in Idiopathic Short Stature. [PDF]
Genes (Basel), 2022 Heterozygous variants in the NPR2 gene, which encodes the B-type natriuretic peptide receptor (NPR-B), a regulator of skeletal growth, were reported in 2–6% cases of idiopathic short stature (ISS). Using next-generation sequencing (NGS), we aimed to assess the frequency of NPR2 variants in our study cohort consisting of 150 children and adolescents ...
Stavber L +9 more
europepmc +4 more sources
A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature. [PDF]
Genome MedBackground A subset of children with short stature do not have an identified clinical explanation after extensive diagnostic evaluation. We hypothesized that a polygenic score for height (PGSheight) could identify children with non-familial idiopathic ...
Shelley JP +5 more
europepmc +3 more sources
Metabolic Characteristics and Discriminative Diagnosis of Growth Hormone Deficiency and Idiopathic Short Stature in Preadolescents and Adolescents. [PDF]
MoleculesGrowth hormone deficiency (GHD) and idiopathic short stature (ISS) are the most common types of short stature (SS), but little is known about their pathogenesis, and even less is known about the study of adolescent SS.
Chang Y +8 more
europepmc +3 more sources
Diagnostic yield of a multigene sequencing approach in children classified as idiopathic short stature. [PDF]
Endocr Connect, 2022 Objective: Most children with short stature remain without an etiologic diagnosis after extensive clinical and laboratory evaluation and are classified as idiopathic short stature (ISS).
Andrade NLM +16 more
europepmc +3 more sources
Idiopathic short stature [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2013 Growth is a complex process and the basic characteristic of child- hood growth monitoring provides insight into the physiological and pathological events in the body.
Vlaški Jovan +5 more
doaj +6 more sources
Idiopathic Short Stature: What to Expect from Genomic Investigations
Endocrines, 2023 Short stature is a common concern for physicians caring for children. In traditional investigations, about 70% of children are healthy, without producing clinical and laboratory findings that justify their growth disorder, being classified as having ...
Nathalia Liberatoscioli Menezes Andrade +4 more
doaj +2 more sources
The influence of pituitary volume on the growth response in growth hormone-treated children with growth hormone deficiency or idiopathic short stature. [PDF]
Ann Pediatr Endocrinol Metab, 2023 Purpose Magnetic resonance imaging (MRI) can be used for assessing the morphology of the pituitary gland in children with short stature. The purposes of this study were: (1) to determine if pituitary volume (PV) can distinguish patients with growth ...
Oh JS +6 more
europepmc +2 more sources
Effects of different therapy regimens to increase final adult height in males at advanced bone age with idiopathic short stature. [PDF]
BMC Pediatr, 2023 Background This retrospective study explored the effect on adult height of a combination of recombinant human growth hormone (rhGH) and aromatase inhibitors (AIs), or rhGH and a gonadotropin-releasing hormone analog (GnRHa), and compared their effects ...
Wang W, Wang Y, Xiao Y, Cao N, Wang Y.
europepmc +2 more sources
Frontiers in Endocrinology, 2023 ObjectiveTo investigate the efficacy of monotherapy with AIs or GnRHa in improving the height of boys with idiopathic short stature (ISS).MethodWe performed a systematic search in Pubmed, The Cochrane Library, Chinese National Knowledge Infrastructure ...
Siqi Wang +8 more
doaj +2 more sources