Results 1 to 10 of about 13,654 (259)

Short-acting growth hormone supplementation for bone age and growth rate in children with idiopathic short stature: a meta-analysis [PDF]

BMC Pediatrics
Objective To explore the effect of short-acting growth hormone (GH) supplementation on bone age and growth rate of children with idiopathic short stature.
Lianlian Yang, Fan Yang
doaj   +3 more sources

A polygenic score for height identifies an unmeasured genetic predisposition among pediatric patients with idiopathic short stature [PDF]

Genome Medicine
Background A subset of children with short stature do not have an identified clinical explanation after extensive diagnostic evaluation. We hypothesized that a polygenic score for height (PGSheight) could identify children with non-familial idiopathic ...
John P. Shelley, Mingjian Shi, Josh F. Peterson, Sara L. Van Driest, Jill H. Simmons, Jonathan D. Mosley   +5 more
doaj   +3 more sources

Idiopathic short stature [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2013
Growth is a complex process and the basic characteristic of child- hood growth monitoring provides insight into the physiological and pathological events in the body.
Vlaški Jovan, Katanić Dragan, Jovanović-Privrodski Jadranka, Kavečan Ivana, Vorgučin Ivana, Obrenović Milan   +5 more
doaj   +7 more sources

SHOX Deletion and Idiopathic Short Stature: What Does the Clinician Need to Know? Case Series Report [PDF]

Diagnostics, 2022
Children diagnosticated with idiopathic short stature (ISS) are probably, in most cases, underdiagnosticated. The genetic causes of ISS may be mutations of genes involved in local regulation of the growth plate or genes involved in the GH-IGF1 axis ...
Maria-Christina Ungureanu, Anamaria Hrisca, Lavinia Caba, Laura Teodoriu, Stefana Bilha, Cristina Preda, Letitia Leustean   +6 more
doaj   +2 more sources

Heterozygous NPR2 Variants in Idiopathic Short Stature. [PDF]

Genes (Basel), 2022
Heterozygous variants in the NPR2 gene, which encodes the B-type natriuretic peptide receptor (NPR-B), a regulator of skeletal growth, were reported in 2–6% cases of idiopathic short stature (ISS). Using next-generation sequencing (NGS), we aimed to assess the frequency of NPR2 variants in our study cohort consisting of 150 children and adolescents ...
Stavber L, Gaia MJ, Hovnik T, Jenko Bizjan B, Debeljak M, Kovač J, Omladič JŠ, Battelino T, Kotnik P, Dovč K.   +9 more
europepmc   +3 more sources

Novel genetic cause of idiopathic short stature [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2017
Traditionally, the growth hormone – insulin-like growth factor I (GH – IGF-I) axis is the most important signaling pathway in linear growth, and defects in this axis present as growth hormone deficiencies or IGF-I deficiencies. However, subtle changes in
Min Jae Kang
doaj   +4 more sources

Diagnostic yield of a multigene sequencing approach in children classified as idiopathic short stature [PDF]

Endocrine Connections, 2022
Objective: Most children with short stature remain without an etiologic diagnosis after extensive clinical and laboratory evaluation and are classified as idiopathic short stature (ISS).
Nathalia Liberatoscioli Menezes Andrade, Mariana Ferreira de Assis Funari, Alexsandra Christianne Malaquias, Paulo Ferrez Collett-Solberg, Nathalia L R A Gomes, Renata Scalco, Naiara Castelo Branco Dantas, Raissa C Rezende, Angelica M F P Tiburcio, Micheline A R Souza, Bruna L Freire, Ana C V Krepischi, Carlos Alberto Longui, Antonio Marcondes Lerario, Ivo J P Arnhold, Alexander A L Jorge, Gabriela Andrade Vasques   +16 more
doaj   +2 more sources

ABNORMAL SLEEP EEC IN IDIOPATHIC SHORT STATURE [PDF]

Pediatric Research, 1987
Polysomnographic recordings were obtained in six patients with idiopathic short stature (ISS), aged 4-10/12 to 16-1/2 yrs and seven patients with growth hormone deficiency (GHD) aged 6-3/12 to 10-5/12 yrs. ISS patients had GH levels ≥ 10 ng/ml and GHD patients had GH levels ≤ 7 ng/ml during provocative testing.
Richard Hk Wu, Yolaine St Louis, Michael J. Thorpy, Scott Breidbart, Paul Saenger   +4 more
openalex   +3 more sources

Comparative efficacy of aromatase inhibitors and gonadotropin-releasing hormone analogue in increasing final height of idiopathic short stature boys: a network meta-analysis [PDF]

Frontiers in Endocrinology, 2023
ObjectiveTo investigate the efficacy of monotherapy with AIs or GnRHa in improving the height of boys with idiopathic short stature (ISS).MethodWe performed a systematic search in Pubmed, The Cochrane Library, Chinese National Knowledge Infrastructure ...
Siqi Wang, Zhixin Wu, Yang Chen, Kuanhong Luo, Zhenhai Cui, Jiaoyue Zhang, Juan Zheng, Kangli Xiao, Huiqing Li   +8 more
doaj   +2 more sources

Metabolic Characteristics and Discriminative Diagnosis of Growth Hormone Deficiency and Idiopathic Short Stature in Preadolescents and Adolescents [PDF]

Molecules
Growth hormone deficiency (GHD) and idiopathic short stature (ISS) are the most common types of short stature (SS), but little is known about their pathogenesis, and even less is known about the study of adolescent SS.
Yajie Chang, Jing Chen, Hongwei Zhu, Rong Huang, Jinxia Wu, Yanyan Lin, Quanquan Li, Guiping Shen, Jianghua Feng   +8 more
doaj   +2 more sources