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Short stature homeoboxcontaining gene and idiopathic short stature
Expert Review of Endocrinology & Metabolism, 2009The term idiopathic short stature (ISS) refers to patients who are short due to various unknown reasons. Although it is clear that multiple factors contribute to final height, genetic factors play a crucial role. Mutations of a human homeobox gene, short stature homeobox-containing (SHOX) gene, have been shown to be associated with the short stature ...
IUGHETTI, Lorenzo +6 more
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Idiopathic Short Stature in Children
Pediatric Annals, 2004Despite a lack of clear etiology or diagnostic tests, treatment for this condition should not be ...
Bradley S, Miller, Donald, Zimmerman
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JAMA, 2014
Approximately 2% of children are defined as having short stature. Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial.To review the management of children with idiopathic short stature, including diagnostic evaluation and therapeutic options.Systematic literature search of PubMed, Embase, and the ...
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Approximately 2% of children are defined as having short stature. Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial.To review the management of children with idiopathic short stature, including diagnostic evaluation and therapeutic options.Systematic literature search of PubMed, Embase, and the ...
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2011
Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex, and population, and in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, according to information on delay of puberty and bone age.
Meinolf Noeker +2 more
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Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex, and population, and in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, according to information on delay of puberty and bone age.
Meinolf Noeker +2 more
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Spontaneous Adult Height in Idiopathic Short Stature
Hormone Research, 2008Two hundred and thirty-six patients with idiopathic short stature (ISS) (184 m, 52 f) who presented at a mean age of 12.2 (range 2.8-17.5) years, a mean height of-2.16 standard deviation score (SDS), a mean target height (THT) of-0.27 SDS (m = 0, were reinvestigated at a mean age of 20.5 (range 18-24) years.
M B, Ranke +4 more
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Genetic studies in idiopathic short stature
Current Opinion in Pediatrics, 2000Idiopathic short stature (ISS) refers to a heterogeneous group of children with marked growth failure of unknown cause, and encompasses familial short stature and constitutional delay of growth. It has been postulated that specific genetic mutations may explain certain cases of growth failure.
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Psychological Functioning in Idiopathic Short Stature
Hormone Research in Paediatrics, 2011Living with idiopathic short stature (ISS) may entail significant risks to psychological functioning and quality of life. Apparent inconsistency among study findings can be resolved if methodological differences among study designs are taken into account (i.e., definition of particular endpoints, sample selection from clinic or population, source of ...
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Treatment of children and adolescents with idiopathic short stature
Nature Reviews Endocrinology, 2013Idiopathic short stature (ISS) is defined as shortness in childhood without a specific cause. ISS may be familial or nonfamilial and may be associated with or without delay of pubertal development. Treatment can be considered in an attempt to reduce the psychological burden caused by short stature in childhood and adult life.
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Growth Hormone Treatment of Idiopathic Short Stature
Hormone Research, 2008Considerable controversy exists about the use of growth hormone (GH) treatment in short children without classical GH deficiency (idiopathic short stature or ISS). ISS is a multifactorial disorder with many potential causes rather than a single diagnostic entity, and it is in essence a diagnosis of exclusion.
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Growth Hormone Use in Children with Idiopathic Short Stature
Annals of Pharmacotherapy, 2004OBJECTIVE: To review the indication, pharmacology, pharmacokinetics, efficacy, and adverse effects of recombinant human growth hormone in children with idiopathic short stature (ISS). DATA SOURCES: A MEDLINE search (1966–December 2003)
Karen L, Weise, Milap C, Nahata
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