Results 171 to 180 of about 6,804 (215)
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New England Journal of Medicine, 2006
A healthy, active 12-year-old boy is in the first percentile for height (133.0 cm [52.4 in.]; −2.25 SD) and the third percentile for weight (29 kg [64 lb]). His physical examination is unremarkable, with normal proportions and no signs of puberty. His bone age is 10 years. His midparental height is 164.5 cm (64.8 in.), and his predicted height is 163.8
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A healthy, active 12-year-old boy is in the first percentile for height (133.0 cm [52.4 in.]; −2.25 SD) and the third percentile for weight (29 kg [64 lb]). His physical examination is unremarkable, with normal proportions and no signs of puberty. His bone age is 10 years. His midparental height is 164.5 cm (64.8 in.), and his predicted height is 163.8
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2011
Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex, and population, and in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, according to information on delay of puberty and bone age.
Joachim Wölfle +2 more
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Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex, and population, and in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, according to information on delay of puberty and bone age.
Joachim Wölfle +2 more
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JAMA, 2014
Approximately 2% of children are defined as having short stature. Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial.To review the management of children with idiopathic short stature, including diagnostic evaluation and therapeutic options.Systematic literature search of PubMed, Embase, and the ...
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Approximately 2% of children are defined as having short stature. Deciding when to pursue recombinant human growth hormone therapy to increase adult height is controversial.To review the management of children with idiopathic short stature, including diagnostic evaluation and therapeutic options.Systematic literature search of PubMed, Embase, and the ...
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The molecular basis of idiopathic short stature
Growth Hormone & IGF Research, 2005Forty years ago, when growth hormone (GH) first became available for use, the molecular basis for growth hormone deficiency (GHD) was entirely unknown. Despite continued difficulties with the biochemical diagnosis of GHD, we now accept the existence of underlying genetic abnormalities as the basis for disorders involving GH secretion.
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Genetic studies in idiopathic short stature
Current Opinion in Pediatrics, 2000Idiopathic short stature (ISS) refers to a heterogeneous group of children with marked growth failure of unknown cause, and encompasses familial short stature and constitutional delay of growth. It has been postulated that specific genetic mutations may explain certain cases of growth failure.
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Spontaneous Adult Height in Idiopathic Short Stature
Hormone Research, 1995Two hundred and thirty-six patients with idiopathic short stature (ISS) (184 m, 52 f) who presented at a mean age of 12.2 (range 2.8-17.5) years, a mean height of -2.16 standard deviation score (SDS), a mean target height (THT) of -0.27 SDS (m = f), were reinvestigated at a mean age of 20.5 (range 18-24) years. 182(142 m, 37 f) (67%) had reached normal
K Kistner +4 more
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Psychological Functioning in Idiopathic Short Stature
Hormone Research in Paediatrics, 2011Living with idiopathic short stature (ISS) may entail significant risks to psychological functioning and quality of life. Apparent inconsistency among study findings can be resolved if methodological differences among study designs are taken into account (i.e., definition of particular endpoints, sample selection from clinic or population, source of ...
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Idiopathic Short Stature: Diagnostic and Therapeutic Approach [PDF]
, 2013 Our clinical case for discussion is about a short statured boy who was 14.6 years old at his first evaluation. He was born after a 39-week gestation as the third child of a non-consanguineous marriage. His birth weight was 3.250 g (−0.3 SDS), and his birth length was not available. His neuropsychomotor development was normal, his school performance was
Alexander A. L. Jorge +1 more
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Idiopathic short stature: Definition, epidemiology, and diagnostic evaluation
Growth Hormone & IGF Research, 2008Idiopathic short stature is a condition in which the height of the individual is more than 2 SD below the corresponding mean height for a given age, sex and population, in whom no identifiable disorder is present. It can be subcategorized into familial and non-familial ISS, and according to pubertal delay.
Wit, J. M. +5 more
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Normal Variant and Idiopathic Short Stature
2018This chapter reviews normal variant short stature, comprised of both familial short stature (FSS) and constitutional delay of growth and puberty (CDGP), as well as idiopathic short stature (ISS). FSS and CDGP are physiologic variants of short stature without an organic cause. Although ISS is not a “normal variant” of short stature, as with FSS and CDGP
Mary M. Lee, Penny M. Feldman
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