Results 11 to 20 of about 52,117 (235)

Novel heterozygous mutation in the SHOX gene leading to familial idiopathic short stature: A case report and literature review. [PDF]

Medicine (Baltimore), 2023
Background: The pathogenic mutation of short stature homeobox (SHOX) gene is one of the main genetic causes of short stature in children, with an incidence rate of 1/1000~1/2000 and the main clinical manifestations are short stature and (or) limb ...
Liu L, Li J, Li J, Hu H, Liu J, Tang P.
europepmc   +2 more sources

Gut microbiota and metabolic changes in children with idiopathic short stature. [PDF]

BMC Pediatr
Background Idiopathic short stature (ISS) is characterized by short stature with unknown causes. Recent studies showed different gut microbiota flora and reduced fecal short-chain fatty acids in ISS children.
Yan L, Ye B, Yang M, Shan Y, Yan D, Fang D, Zhang K, Yu Y.   +7 more
europepmc   +2 more sources

The Combination of Aromatase Inhibitors and GH Treatment for Idiopathic Short Stature in Male Adolescents.

J Clin Endocrinol Metab
Objective To evaluate the efficacy and safety in adolescent boys with idiopathic short stature (ISS) when treated with third-generation aromatase inhibitors (AIs), the combination of letrozole or anastrozole with recombinant human GH (rhGH), and compare ...
Cui Y, Zhang Q, Hou L, Luo X.
europepmc   +2 more sources

Anastrozole vs Letrozole to Augment Height in Pubertal Males With Idiopathic Short Stature: A 3-Year Randomized Trial. [PDF]

J Endocr Soc
Context Insufficient efficacy and safety data for off-label use of aromatase inhibitors to augment height in boys with short stature. Objective To compare anastrozole and letrozole in treatment of idiopathic short stature in pubertal boys.
Zegarra W, Ranadive S, Toulan D, Neely EK.   +3 more
europepmc   +2 more sources

Mucopolysaccharidosis Type I Disease Prevalence Among Patients With Idiopathic Short Stature in Saudi Arabia: Protocol for a Multicenter Cross-sectional Study

JMIR Research Protocols, 2021
BackgroundSince the underlying cause of idiopathic short stature can indeed be undiagnosed mucopolysaccharidosis type I, it is critical to identify patients with mucopolysaccharidosis type I among screened patients with idiopathic
Danyah Alsafadi, Aly Ezzat, Fatima Altamimi, Marwan ElBagoury, Mohammed Olfat, Mohammed Saleh, Sherif Roushdy, Yahia Aktham   +7 more
doaj   +2 more sources

Effect of long-acting PEGylated growth hormone for catch-up growth in children with idiopathic short stature: a 2-year real-world retrospective cohort study. [PDF]

Eur J Pediatr
Several evidence gaps exist regarding the use of long-acting polyethylene glycol recombinant human growth hormone (PEG-rhGH) in children with idiopathic short stature (ISS), particularly studies conducted in real-world settings, with long-term follow-up,
Xie L, Li Y, Zhang J, Guo S, Chen Q, Ma H, Jiang W.   +6 more
europepmc   +2 more sources

Investigating Novel Therapeutic Approaches for Idiopathic Short Stature: Targeting siRNA and Growth Hormone Delivery to the Growth Plate Using Exosome Nanoparticles. [PDF]

Adv Sci (Weinh)
Idiopathic short stature (ISS) is a common childhood condition with largely unknown underlying causes. Recent research highlights the role of circulating exosomes in the pathogenesis of various disorders, but their connection to ISS remains unexplored ...
Yuan J, Wang Y, Huang Y, Li S, Zhang X, Wu Z, Zhao W, Zhu J, Zhang J, Huang G, Yu P, Cheng X, Wang X, Liu X, Jia J.   +14 more
europepmc   +2 more sources

Novel genetic cause of idiopathic short stature [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2017
Traditionally, the growth hormone – insulin-like growth factor I (GH – IGF-I) axis is the most important signaling pathway in linear growth, and defects in this axis present as growth hormone deficiencies or IGF-I deficiencies. However, subtle changes in
Min Jae Kang
doaj   +3 more sources

Children with idiopathic short stature have significantly different gut microbiota than their normal height siblings: a case-control study. [PDF]

Front Endocrinol (Lausanne)
Objectives To investigate the role of gut microbiota (GM) in pathogenesis of idiopathic short stature (ISS) by comparing GM of ISS children to their normal-height siblings.
Lazar L, Eshel A, Moadi L, Yackobovitch-Gavan M, Bar-Maisels M, Shtaif B, Nevo M, Phillip M, Turjeman S, Koren O, Gat-Yablonski G.   +10 more
europepmc   +2 more sources

Evaluation of craniofacial morphology in short-statured children: growth hormone deficiency versus idiopathic short stature [PDF]

Yeungnam University Journal of Medicine, 2021
Short stature is defined as a height below the 3rd percentile or more than two standard deviations below the mean for a given age, sex, and population. There have been inconsistent results regarding craniofacial morphology in short-statured children.
Ki Bong Kim, Eun-Kyong Kim, Kyung Mi Jang, Min Seon Kim, Eun Young Park   +4 more
openaire   +4 more sources