Results 21 to 30 of about 395,822 (284)

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

Journal of Experimental Medicine, 2011
VISTA suppresses T cell proliferation and cytokine production and can influence autoimmunity and antitumor responses in mice.
Li Wang, Rotem Rubinstein, J. Lines, A. Wasiuk, Cory L. Ahonen, Yanxia Guo, Li-Fan Lu, David C. Gondek, Yan Wang, R. Fava, A. Fiser, S. Almo, R. Noelle   +12 more
semanticscholar   +1 more source

Exploring Cancer Genomics with Graph Convolutional Networks: A Comparative Explainability Study with Integrated Gradients and SHAP [PDF]

BIO Web of Conferences
In the rapidly advancing field of cancer genomics, identifying new cancer genes and understanding their molecular mechanisms are essential for advancing targeted therapies and improving patient outcomes.
Battula Joshit, Jillelamudi Venkata Ashok, Sammeta Chaitanya Krishna, Amilpur Santhosh   +3 more
doaj   +1 more source

Assessing Natural Gas Versus CO₂ Potential Underground Storage Sites in Greece: A Pragmatic Approach †

Materials Proceedings, 2022
Although subsurface traps have been regularly explored for hydrocarbon exploration, natural gas and CO2 storage has drawn industrial attention over the past few decades, thanks to the increasing demand for energy resources and the need for greenhouse gas
Vagia Ioanna Makri, Spyridon Bellas, Vasilis Gaganis   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations

Leukemia, 2012
PCR-based immunoglobulin (Ig)/T-cell receptor (TCR) clonality testing in suspected lymphoproliferations has largely been standardized and has consequently become technically feasible in a routine diagnostic setting.
A. Langerak, P. Groenen, Monika Brüggemann, K. Beldjord, Cristiana Bellan, Lisa Bonello, E. Boone, G. Carter, M. Catherwood, Frédéric Davi, M. Delfau-Larue, T. Diss, P. Evans, P. Gameiro, R. G. Sanz, D. González, D. Grand, A. Håkansson, Michael Hummel, Hongxiang Liu, L. Lombardía, Elizabeth Macintyre, B. Milner, Santiago Montes-Moreno, E. Schuuring, Marcel Spaargaren, E. Hodges, J. Dongen   +27 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

CARACTERIZAÇÃO GEOMORFOLÓGICA DA REGIÃO DA SERRA DO BOTURUNA, ESTADO DE SÃO PAULO

Revista de Geografia (Recife), 2011
Este trabalho apresenta a caracterização geomorfológica da Região da Serra do Boturuna, no Estado de São Paulo. Tombada como patrimônio natural pelo Conselho de Defesa do Patrimônio Histórico, Arqueológico e Artístico e Turístico do Estado de São Paulo ...
Sandro Francisco Detoni, Rosely Aparecida Liguori Imbernon, Yuri Tavares Rocha   +2 more
doaj   +2 more sources

Considerações sobre a evolução do Sistema Nacional de Unidades de Conservação e o ordenamento territorial da Amazônia: interações entre o Estado e a Ciência

Desenvolvimento e Meio Ambiente, 2010
O presente artigo tem o objetivo de traçar considerações sobre a evolução das Unidades de Conservaçãoem meio ao ordenamento territorial da Amazônia e, para compreender esse processo, propõecinco períodos.
Josimara Martins Dias, Newton Müller Pereira   +1 more
doaj   +1 more source

New and Rapid Analytical Method Using HPLC-MS Detection for Acrylamide Determination in Black Ripe Olives

Foods, 2023
The presence of acrylamide, a known human carcinogen, in various heated foods raises significant concerns among consumers. Therefore, the development of a good analytical method is of paramount interest to the scientific community.
Mercedes Brenes-Álvarez, Eva María Ramírez, Manuel Brenes, Pedro García-García, Eduardo Medina, Concepción Romero   +5 more
doaj   +1 more source