Results 31 to 40 of about 395,822 (284)
American Journal of Transplantation, 2005 Current success in organ transplantation is dependent upon the use of calcineurin‐inhibitor‐based immunosuppressive regimens. Unfortunately, current immunotherapy targets molecules with ubiquitous expression resulting in devastating non‐immune side ...
C. Larsen +17 more
semanticscholar +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
AVALIAÇÃO DA RECARGA DO AQUÍFERO FREÁTICO: UM ESTUDO DE CASO NO MUNICÍPIO DE TAUBATÉ-SP
Revista Águas Subterrâneas, 2007 Este trabalho apresenta uma estimativa da recarga do aqüífero freático na bacia do rio Una, Município de Taubaté, como resultado de pesquisas em políticas públicas a fim de subsidiar o uso sustentável dos recursos hídricos superficiais e subterrâneos no ...
Hélio Nóbile Diniz +4 more
doaj
IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action
Annual Review of Immunology, 2023 The evolution of IgE in mammals added an extra layer of immune protection at body surfaces to provide a rapid and local response against antigens from the environment. The IgE immune response employs potent expulsive and inflammatory forces against local antigen provocation, at the risk of damaging host tissues and causing allergic disease.
McDonnell, James +3 more
openaire +4 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Revista Águas Subterrâneas, 2007 Nas seqüências sedimentares da Bacia do Paraná ocorre um enorme número de corpos intrusivos de rochas basálticas da Formação Serra Geral, individualmente com até dezenas de quilômetros quadrados de área e espessuras que ultrapassam 300 metros.
Heinrich Theodor Frank +3 more
doaj
Frontiers in Plant Science, 2021 Fatty acid composition of olive oil has an important effect on the oil quality to such an extent that oils with a high oleic and low linoleic acid contents are preferable from a nutritional and technological point of view.
M. Luisa Hernández +3 more
doaj +1 more source
The Astonishing Diversity of Ig Classes and B Cell Repertoires in Teleost Fish
Front. Immun., 2013 With lymphoid tissue anatomy different than mammals, and diverse adaptations to all aquatic environments, fish constitute a fascinating group of vertebrate to study the biology of B cell repertoires in a comparative perspective.
S. Fillatreau +6 more
semanticscholar +1 more source