Results 51 to 60 of about 395,822 (284)
Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule
mAbs, 2013 Several bispecific antibody-based formats have been developed over the past 25 years in an effort to produce a new generation of immunotherapeutics that target two or more disease mechanisms simultaneously.
C. Jakob +6 more
semanticscholar +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Revista Águas Subterrâneas, 1998 O presente trabalho representa uma contribuição ao estudo da geometria, características hidrodinâmicas e hidroquímicas dos aqüíferos formados pelos sedimentos arenosos costeiros da Cidade do Rio de Janeiro, tomando-se como caso de estudo o sistema ...
Gerson Cardoso da Silva Júnior +3 more
doaj
Revista Águas Subterrâneas, 2004 RESUMO A determinação e o monitoramento de metais pesados em águas, solos e sedimentos são extremamente importantes para controle ambiental. Neste trabalho determinaram-se as concentrações e disponibilidade de íons metálicos poluentes originados de ...
Raphael Hypolito +1 more
doaj +1 more source
Journal of Experimental Medicine, 1996 The T lymphocytes mediating autoimmune destruction of pancreatic beta cells in the nonobese diabetic (NOD) mouse model of insulin-dependent diabetes mellitus (IDDM) may be generated due to functional defects in hematopoietically derived antigen ...
Davidv Serreze +8 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Territorium: Revista Portuguesa de riscos, prevenção e segurança, 2011 O objetivo deste trabalho é demonstrar criticamente a forma pela qual a questão da erosão tem sido tratada no município de São Pedro (Brasil) ao longo das últimas décadas.
Archimedes Perez-Filho +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion
FEBS Open Bio, EarlyView.Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng +2 more
wiley +1 more source