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Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis in the world. The etiology is unknown but a dysregulated T-cell immune response to viral, bacterial, and food antigens activating mucosal plasma cells to produce polymeric IgA has been proposed. No serological test exists to diagnosis IgAN.
Jonathan J, Taliercio, Ali, Mehdi
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IgA nephropathy is a syndrome and probably the most important glomerular disease in terms of incidence and mortality. This review documents the clinical and pathological features and concentrates on the evolving thoughts regarding pathogenesis and treatment.
A R, Clarkson +4 more
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Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but current biochemical and genetic data implicate overproduction of aberrantly glycosylated IgA1.
Schena, FP +6 more
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IgA Glycosylation in IgA Nephropathy [PDF]
IgA nephropathy (IgAN) is the commonest form of glomerulonephritis in developed countries where renal biopsy is widely practiced1. IgAN is defined by the deposition of IgA in the glomerular mesangium. Most typically, patients present with episodes of visible haematuria, which often concide with respiratory or gastrointestinal infection.
A, Allen, J, Feehally
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In many engineering challenges, the whole interaction between the structural domain and the acoustic domain must be taken into account, particularly for the acoustic analysis of thin structures submerged in water.
Xiuyun Chen +8 more
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IgA subclass and IgA deficiency
There are two subclasses of IgA, IgA1 and IgA2, and its heavy chains are encoded by two different genes, alpha1 and alpha2 genes. These two subclasses play important roles in the first line of defense, and the amount ratio of these molecules in secretions varies.
Hideo, Kaneko +2 more
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Polyclonal Antibody Therapies for Clostridium difficile Infection
Clostridium difficile infection has emerged as a growing worldwide health problem. The colitis of Clostridium difficile infection results from the synergistic action of C. difficile secreted toxins A and B upon the colon mucosa.
Michael R. Simon +2 more
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Лінійний IgA-бульозний дерматоз у дитини під час воєнного стану. Клінічний випадок
Лінійний IgA-бульозний дерматоз (хронічна хвороба дитинства) - рідкісне аутоімунне субепітеліальне везикулобульозне захворювання, обумовлене утворенням аутоантитіл IgA, спрямованих проти різних гемідесмосомних антигенів, яке зустрічається частіше в дітей
S.M. Nedelska +3 more
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Vogt-Koyanagi-Harada Syndrome in Two Patients with Immunoglobulin A Nephropathy [PDF]
We describe herein 2 patients who developed Vogt-Koyanagi-Harada syndrome in the course of renal biopsy-proven immunoglobulin A (IgA) nephropathy. A 61-year-old man with an 11-year history of IgA nephropathy and a 16-year history of thyroiditis, and a 56-
Masuda, Ikuya +5 more
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Stressful life events are associated with low secretion rates of immunoglobulin A in saliva in the middle aged and elderly [PDF]
Whether chronic stress experience is related to down-regulation of secretory immunoglobulin A (S-IgA) was tested in two substantial cohorts, one middle-aged (N = 640) and one elderly (N = 582), comprising similar numbers of men (N = 556) and women (N ...
Phillips, A.C. +13 more
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