Results 11 to 20 of about 169,930 (262)
Nature Reviews Disease Primers, 2016 Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but current biochemical and genetic data implicate overproduction of aberrantly glycosylated IgA1.
Sydney C W Tang +2 more
exaly +9 more sources
The Role of IgA in the Pathogenesis of IgA Nephropathy [PDF]
International Journal of Molecular Sciences, 2019 Immunoglobulin A (IgA) is the most abundant antibody isotype produced in humans, predominantly present in the mucosal areas where its main functions are the neutralization of toxins, prevention of microbial invasion across the mucosal epithelial barrier, and simultaneous maintenance of a physiologically indispensable symbiotic relationship with ...
Martina Perse, Željka Večerić-Haler
exaly +4 more sources
Relationship Between IgG and IgA titers of Chlamydia Trachomatis and Tubal Obstruction in Infertile Women and Comparison of Antibody Titers with Normal Women [PDF]
Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2021 Introduction: The prevalence of infertility in the world is increasing and treatment of infertility is one of the important issues. This study was performed with aim to investigate the relationship between IgG and IgA titers of Chlamydia Trachomatis and ...
Ebrahim Alijani +3 more
doaj +1 more source
DETERMINING THE DEGREE OF PLAYER ENGAGEMENT IN A COMPUTER GAME WITH ELEMENTS OF A SOCIAL CAMPAIGN USING COGNITIVE NEUROSCIENCE TECHNIQUES [PDF]
Applied Computer Science, 2022 Due to the popularity of video games in various applications, including both commer-cial and social marketing, there is a need to assess their content in terms of player satisfaction, already at the production stage. For this purpose, the indices used in
Konrad BIERCEWICZ +3 more
doaj +1 more source
No child should suffer from vitamin K deficiency‐induced bleeding disorders
Clinical Case Reports, 2022 We encountered an 11‐day‐old male neonate with vitamin K deficiency‐induced intracranial hemorrhage, despite receiving oral vitamin K2 (menaquinone‐4) prophylaxis according to Japanese guidelines.
Masazumi Miyahara, Kyoko Osaki
doaj +1 more source
F1000Research, 2020 Shotgun metagenomics sequencing is a powerful tool for the characterization of complex biological matrices, enabling analysis of prokaryotic and eukaryotic organisms and viruses in a single experiment, with the possibility of reconstructing de novo the ...
Federica Cattonaro +3 more
doaj +1 more source
A global neuronopathic gaucher disease registry (GARDIAN): a patient-led initiative
Orphanet Journal of Rare Diseases, 2023 Background Gaucher disease (GD) is a rare autosomal recessive lysosomal storage disorder. GD types 2 and 3 are known as neuronopathic Gaucher disease (nGD) because they have brain involvement that progresses over time.
Tanya Collin-Histed +7 more
doaj +1 more source
IgA Glycosylation and IgA Immune Complexes in the Pathogenesis of IgA Nephropathy [PDF]
Seminars in Nephrology, 2008 Circulating immune complexes containing aberrantly glycosylated IgA1 play a pivotal role in the pathogenesis of IgA nephropathy (IgAN). A portion of IgA1 secreted by IgA1-producing cells in patients with IgAN is galactose-deficient and consequently recognized by anti-glycan IgG or IgA1 antibodies.
Jan, Novak +3 more
openaire +2 more sources
IgA Glycosylation in IgA Nephropathy [PDF]
, 1998 IgA nephropathy (IgAN) is the commonest form of glomerulonephritis in developed countries where renal biopsy is widely practiced1. IgAN is defined by the deposition of IgA in the glomerular mesangium. Most typically, patients present with episodes of visible haematuria, which often concide with respiratory or gastrointestinal infection.
A, Allen, J, Feehally
openaire +2 more sources
Role of macromolecular IgA in IgA nephropathy [PDF]
Kidney International, 2005 Primary IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis, leading to progressive renal failure in almost one third of the patients. The disease is characterized by mesangial deposits of IgA. The pathogenesis of IgAN remains incompletely understood.
Van Der Boog, Paul J.M. +3 more
openaire +2 more sources