Results 1 to 10 of about 1,100,660 (163)

A comprehensive antigen-antibody complex database unlocking insights into interaction interface [PDF]

eLife
Antibodies are critical components of the vertebrate immune system and possess a wide array of biomedical applications. Elucidating the complex interactions between antibodies and antigens is an important step in drug development.
Yuwei Zhou, Wenwen Liu, Ziru Huang, Yushu Gou, Siqi Liu, Lixu Jiang, Yue Yang, Jian Huang   +7 more
doaj   +2 more sources

Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function [PDF]

Frontiers in Immunology
Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation.
Tanusya Murali Murali, Tanusya Murali Murali, Tanusya Murali Murali, Yue Gu, Yue Gu, Rabiatul Adawiyah Minhat, Jiawei Yap, Jiawei Yap, Kathryn J. Wood, Cheng-I Wang, Nicholas R. J. Gascoigne, Nicholas R. J. Gascoigne, Vathsala Anantharaman, Vathsala Anantharaman, Paul Anthony MacAry, Paul Anthony MacAry, Paul Anthony MacAry   +16 more
doaj   +2 more sources

Development of egg yolk-based polyclonal antibodies and immunoprophylactic potential of antigen-antibody complex against infectious bursal disease [PDF]

Veterinary and Animal Science
A study conducted in the Faisalabad district sampled 50 cases across five IBD outbreaks, revealing an alarming 80 % infection rate among poultry.
Sanaullah Sajid, Sajjad ur Rahman, Mashkoor Mohin, Zia ud Din Sindhu   +3 more
doaj   +2 more sources

A highly sensitive terbium–keton complex-based fluorescent immunoassay for detection of methicillin-resistant Staphylococcus aureus (MRSA) antigen in milk, farmer hand swabs, and cattle drinking water [PDF]

RSC Advances
This study presents the development and validation of a novel fluorescence-based immunoassay for the rapid and sensitive detection of methicillin-resistant Staphylococcus aureus (MRSA) antigen using a terbium–keton complex (Tb-2,keton) as the luminescent
Norhan M. Ali, Shereen S. Maghraby, Nour Eddine M. Ghoneimy, Youssef M. Hassan, Menna H. Mustafa, Ahmed O. Youssef, Wafaa H. Abdel-Ghaffar, Hesham G. Afify, Ekram H. Mohamed, Alaa R. I. Morsy, Ghada M. Elsadek, Mohamed S. Mohy Eldin, Mona N. Abou-Omar, W. A. Abdelkawy, Samir A. Nassif, Mohamed S. Attia   +15 more
doaj   +2 more sources

Correlation of N-glycan dynamics and interaction network with allosteric antigen binding and Fc receptor recognition

Exploration of Immunology, 2021
Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect antibody drug characteristics and quality control.
Buyong Ma
doaj   +1 more source

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

mAbs, 2022
A conventional antibody targeting a soluble antigen in circulation typically requires a huge dosage and frequent intravenous administration to neutralize the antigen.
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori, Tomoyuki Igawa   +16 more
doaj   +1 more source

Learned features of antibody-antigen binding affinity

Frontiers in Molecular Biosciences, 2023
Defining predictors of antigen-binding affinity of antibodies is valuable for engineering therapeutic antibodies with high binding affinity to their targets.
Nathaniel L. Miller, Nathaniel L. Miller, Thomas Clark, Thomas Clark, Rahul Raman, Rahul Raman, Ram Sasisekharan, Ram Sasisekharan   +7 more
doaj   +1 more source

Application of fluorescein copolymer to improve the efficiency of counter-immunoelectrophoresis for diagnostics of animal infectious diseases [PDF]

The Ukrainian Biochemical Journal, 2021
The counter-immunoelectrophoresis (CIE) is a highly specific, simple and rapid method, which does not require expensive equipment, input materials and long-term staff training as compared with other express methods of viral infections diagnostic. Despite
D. D. Ostapiv, N. V. Kuz’mina, М. R. Kozak, Shan Hu, V. V. Vlizlo, I. Ya. Kotsiumbas, S. M. Varvarenko, V. Ya. Samaryk, N. G. Nosova, M. V. Yakoviv   +9 more
doaj   +1 more source

NbX: Machine Learning-Guided Re-Ranking of Nanobody–Antigen Binding Poses

Pharmaceuticals, 2021
Modeling the binding pose of an antibody is a prerequisite to structure-based affinity maturation and design. Without knowing a reliable binding pose, the subsequent structural simulation is largely futile.
Chunlai Tam, Ashutosh Kumar, Kam Y. J. Zhang   +2 more
doaj   +1 more source

Design of Antibody-Functionalized Polymeric Membranes for the Immunoisolation of Pancreatic Islets

Applied Sciences, 2020
An immunoencapsulation strategy for pancreatic islets aimed to reduce the risk of rejection in transplanted patients due to the immune response of the host organism is proposed.
Anna Cavallo, Ugo Masullo, Alessandra Quarta, Alessandro Sannino, Amilcare Barca, Tiziano Verri, Marta Madaghiele, Laura Blasi   +7 more
doaj   +1 more source