Results 11 to 20 of about 7,021,714 (299)

Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes

mAbs, 2021
Therapeutic proteins including antibodies and Fc-fusion proteins undergo a large number of chemical modifications during cell culture, purification, storage and in human circulation.
Pavel V. Bondarenko, Andrew C. Nichols, Gang Xiao, Rachel Liuqing Shi, Pik Kay Chan, Thomas M Dillon, Fernando Garces, David J. Semin, Margaret S. Ricci   +8 more
doaj   +1 more source

Quantitative Description of Surface Complementarity of Antibody-Antigen Interfaces

Frontiers in Molecular Biosciences, 2021
Antibodies have the remarkable ability to recognise their cognate antigens with extraordinary affinity and specificity. Discerning the rules that define antibody-antigen recognition is a fundamental step in the rational design and engineering of ...
Lorenzo Di Rienzo, Edoardo Milanetti, Edoardo Milanetti, Giancarlo Ruocco, Giancarlo Ruocco, Rosalba Lepore   +5 more
doaj   +1 more source

Effect of Trastuzumab–HER2 Complex Formation on Stress-Induced Modifications in the CDRs of Trastuzumab

Frontiers in Chemistry, 2022
Asparagine deamidation and aspartic acid isomerization in the complementarity determining regions (CDRs) of monoclonal antibodies may alter their affinity to the target antigen.
Baubek Spanov, Victoria Aboagye, Oladapo Olaleye, Natalia Govorukhina, Nico C. van de Merbel, Nico C. van de Merbel, Rainer Bischoff   +6 more
doaj   +1 more source

pH-Regulated Strategy and Mechanism of Antibody Orientation on Magnetic Beads for Improving Capture Performance of Staphylococcus Species

Foods, 2022
Immunomagnetic beads (IMBs) have been widely used to capture and isolate target pathogens from complex food samples. The orientation of the antibody immobilized on the surface of magnetic beads (MBs) is closely related to the effective recognition with ...
Fuying Kang, Yin Yang, Jingwen Li, Erning Chen, Tian Hong, Lulu Zhao, Meihong Du   +6 more
doaj   +1 more source

Immune-Complex Mimics as a Molecular Platform for Adjuvant-Free Vaccine Delivery [PDF]

, 2013
Protein-based vaccine development faces the difficult challenge of finding robust yet non-toxic adjuvants suitable for humans. Here, using a molecular engineering approach, we have developed a molecular platform for generating self-adjuvanting immunogens
Stylianou, E, Gil Reynolds Diogo, Reljic Rajko, Matthew J Paul, Pepponi Ilaria, Ma Julian K.-C., Julian K.-C. Ma, Drake, PM, Diogo Gil Reynolds, Drake Pascal M. W., Matthew J. Paul, Pepponi, I, Pascal M. W. Drake, Pascal M W Drake, van Dolleweerd Craig, Diogo, GR, Elena Stylianou, Craig van Dolleweerd, Rajko Reljic, Julian K-C Ma, Reljic, R, Ilaria Pepponi, van Dolleweerd, C, Paul Matthew J., Stylianou Elena, Ma, JK, Paul, MJ   +26 more
core   +2 more sources

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans [PDF]

, 2013
Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP).
Both, L, Bulmer-Thomas, B., Banyard, AC, Selden, D., Altmann, F, Craig van Dolleweerd (406086), David Selden (4911475), Selden, D, Ashley C Banyard (16267520), Both, L., Banyard, A.C., Edward Wright (4468198), Bulmer-Thomas, B, Fooks, AR, Friedrich Altmann (33138), Wright, E, van Dolleweerd, C., Fooks, A.R., Ma, J.K.C., Julian K C Ma (16267529), Leonard Both (16267517), van Dolleweerd, C, Ma, JK, Wright, E., Altmann, F., Anthony R Fooks (16267526), Bianca Bulmer-Thomas (16267523)   +26 more
core   +1 more source

STUDIES ON ANTIGEN-ANTIBODY COMPLEXES [PDF]

The Journal of Experimental Medicine, 1971
The Journal of Experimental Medicine, Vol. 133, No. 4, April 1, 1971, page 719, line 1: For 357,000 read 313,000.
M, Mannik, M P, Arend, A P, Hall, B C, Gilliland   +3 more
openaire   +4 more sources

Structural consensus among antibodies defines the antigen binding site. [PDF]

PLoS Computational Biology, 2012
The Complementarity Determining Regions (CDRs) of antibodies are assumed to account for the antigen recognition and binding and thus to contain also the antigen binding site.
Vered Kunik, Bjoern Peters, Yanay Ofran
doaj   +1 more source

The COVID Complex: A Review of Platelet Activation and Immune Complexes in COVID-19

Frontiers in Immunology, 2022
Coronavirus disease 2019 (COVID-19) is a highly prothrombotic viral infection that primarily manifests as an acute respiratory syndrome. However, critically ill COVID-19 patients will often develop venous thromboembolism with associated increases in ...
Stefan D. Jevtic, Ishac Nazy, Ishac Nazy
doaj   +1 more source

In Silico Methods in Antibody Design

Antibodies, 2018
Antibody therapies with high efficiency and low toxicity are becoming one of the major approaches in antibody therapeutics. Based on high-throughput sequencing and increasing experimental structures of antibodies/antibody-antigen complexes, computational
Jun Zhao, Ruth Nussinov, Wen-Jin Wu, Buyong Ma   +3 more
doaj   +1 more source