Results 71 to 80 of about 220,566 (226)

A Refractory Leg Skin Ulcer Associated With Multiple Myeloma Successfully Treated With Plasma Exchange, Lenalidomide, and Dexamethasone

JEADV Clinical Practice, EarlyView.
ABSTRACT Multiple myeloma (MM) is a malignant plasma cell disorder that primarily presents with CRAB symptoms (calcium elevation, renal failure, anemia, and bone abnormalities). In rare cases, MM manifests with systemic complications like skin ulcers, which present management challenges. Here, we report a 78‐year‐old Japanese man with MM and refractory
Naoko Hattori, Yutaka Kuwatsuka, Tomoka Waseda, Daisuke Ehara, Koji Ando, Hiroyuki Murota   +5 more
wiley   +1 more source

Posterior lumbar subcutaneous edema as the rare sign of IgA vasculitis (Henoch-Schönlein purpura): A case of a child

Radiology Case Reports, 2021
Posterior lumbar subcutaneous edema (PLSE) is often found on MRI in adults with obesity or various lumbar conditions. We report a case of a 6-year-old boy with IgA vasculitis (Henoch-Schönlein purpura) along with PSLE observed on CT and MRI.
Toshinori Yasumura, MD, Tetsuya Katsumori, MD, Osamu Kizu, MD, Hiromu Umehara, MD, Yoshitomo Nakai, MD   +4 more
doaj   +1 more source

Systemic Activation of Neutrophils by Immune Complexes Is Critical to IgA Vasculitis

Journal of Immunology, 2022
In IgA vasculitis (IgAV) perivascular deposition of IgA1 immune complexes (IgA-ICs) is traditionally considered the fundamental trigger for polymorphonuclear neutrophil (PMN)–mediated damage.
Sarah Mayer-Hain, Kathleen Gebhardt, M. Neufeld, J. Ehrchen, K. Molyneux, Jonathan Barratt, Eva Nattkemper, Dennis Gerloff, J. Roth, T. Vogl, K. I. Pappelbaum, C. Sunderkötter   +11 more
semanticscholar   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

National recommendations for the management of children and young people with IgA vasculitis: a best available evidence, group agreement-based approach

Archives of Disease in Childhood
Objective IgA vasculitis (IgAV) is the most frequently experienced subtype of vasculitis seen in children. Most children fully recover, however, complications including chronic kidney disease are recognised.
L. Oni, Caroline Platt, M. Marlais, L. McCann, F. Barakat, Markus W Hesseling, Hannah Cottis, Sue Protheroe, Gabrielle Haigh, K. Nott, J. Marro, E. King, Janet Kelly, Jill Sussens, S. Mulvaney, T. Whitby, I. Morgan, Amita Sharma, Reem Al-Jayyousi, C. Cheung, C. Ng, Anthony Lander, William H. Simmons, C. Melling, Rebecca Grandison, Leanne Treitl, Alan D. Salama, Jan Dudley   +27 more
semanticscholar   +1 more source

Apolipoprotein M Serum Levels Correlate with IgA Vasculitis and IgA Vasculitis Nephritis

Disease Markers, 2019
Objective. IgA vasculitis (lgAV) is the most frequent vessel vasculitis in children, and the prognosis is related to the children’s age and degree of nephritis. This study is aimed at investigating serum apolipoprotein M (apoM) levels in patients with lgAV patients and at evaluating the association between apoM and disease severity.Methods.
Jiali Wu, Lagu He, Le Bai, Li Tan, Min Hu   +4 more
openaire   +2 more sources

Beyond the Kidney and Lung: Cutaneous and Mucosal Clues to Human Hantavirus Disease

International Journal of Dermatology, EarlyView.
Rodent exposure and aerosolized excreta can lead to hantavirus infection with systemic endothelial injury and capillary leak, resulting in thrombocytopenia and syndromes such as HPS/HCPS and HFRS/NE. Early dermatologic and mucosal findings, including flushing, conjunctival injection, petechiae/purpura, and mucosal bleeding, may provide important clues ...
Giuseppe Gallo, Pietro Quaglino, Simone Ribero   +2 more
wiley   +1 more source

Vaccination and Risk of Childhood IgA Vasculitis [PDF]

Pediatrics, 2018
BACKGROUND AND OBJECTIVES: Immunoglobulin A vasculitis (IgAV) might develop after vaccination. However, this potential relationship is essentially based on case reports, and robust pharmaco-epidemiologic data are scarce. We aimed to investigate the effect of vaccination on short-term risk of IgAV in children.
Maryam, Piram, Solange, Gonzalez Chiappe, Fouad, Madhi, Tim, Ulinski, Alfred, Mahr   +4 more
openaire   +2 more sources

Australian clinical practice guideline: diagnosis and treatment of idiopathic multicentric Castleman disease

Internal Medicine Journal, EarlyView.
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare condition. The pathogenesis is incompletely understood; however, interleukin‐6 (IL‐6) is a major mediator. The clinical presentation is heterogeneous, from mild constitutional symptoms to severe multi‐organ failure.
Dipti Talaulikar, Jun Yen Ng, Adam Bryant, Annmarie Bosco, Hugh C. Caterson, Pratyush Giri, Pravin Hissaria, Simon J. Harrison, Stephen Lade, Connull Leslie, Jacinta Perram, H. Miles Prince, Dejan Radeski, Maureen Rischmueller, Craig Wallington‐Gates, Nicholas Weber, Alberta Hoi   +16 more
wiley   +1 more source

Paraneoplastic IgA nephropathy and IgA vasculitis in mesothelioma [PDF]

International Journal of Case Reports and Images, 2019
Immunoglobulin A (IgA) vasculitis and IgA nephropathy have been associated with underlying malignancies when present in adult populations. To date, we have found only two previously reported cases of IgA vasculitis and one IgA nephropathy case associated with mesothelioma, with our patient being the fourth.
Catherine Abendroth, Gurwant Kaur
openaire   +1 more source