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Molecular IGF-1 and IGF-1 Receptor Defects: From Genetics to Clinical Management
2013Molecular defects of the insulin-like growth factor 1 gene (IGF1) are rare in the human. Only three homozygous and two families with heterozygous mutations of the IGF1 gene have been described, resulting in a variable degree of intrauterine and postnatal growth retardation, microcephaly, developmental delay and deafness.
Walenkamp, M.J.E. +2 more
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S-nitrosylation of the IGF-1 receptor disrupts the cell proliferative action of IGF-1
Biochemical and Biophysical Research Communications, 2017The insulin-like growth factor 1 receptor (IGF-1R) is a disulfide-linked heterotetramer containing two α-subunits and two β-subunits. Earlier studies demonstrate that nitric oxide (NO) can adversely affect IGF-1 action in the central nervous system.
Kazushi, Okada, Bao-Ting, Zhu
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1996
The syndrome of cancer cachexia is associated with complex metabolic changes leading to progressive weight loss. In the absence of effective treatment, this malnourished state leads to decreased survival in cancer patients, independent of the stage of disease.
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The syndrome of cancer cachexia is associated with complex metabolic changes leading to progressive weight loss. In the absence of effective treatment, this malnourished state leads to decreased survival in cancer patients, independent of the stage of disease.
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2008
Retinopathy continues to be a major cause of blindness in children (retinopathy of prematurity, ROP), in adults (diabetic retinopathy), and in the elderly (age-related macular degeneration), despite current therapy. Although ablation of the retina reduces the incidence of blindness by suppressing the neovascular phase of ROP and diabetic retinopathy ...
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Retinopathy continues to be a major cause of blindness in children (retinopathy of prematurity, ROP), in adults (diabetic retinopathy), and in the elderly (age-related macular degeneration), despite current therapy. Although ablation of the retina reduces the incidence of blindness by suppressing the neovascular phase of ROP and diabetic retinopathy ...
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Studium interakce inzulinu, IGF-1/2 a analogu IGF-1 s receptory inzulinu a IGF-1
2014Insulin-like growth factors 1 and 2 (IGF-1/2) are single-chain peptides exerting homology (in both amino-acid sequence and tertiary structure) to insulin. The main function of these peptides is promoting celular growth, proliferation and differentiation.
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Novartis Foundation symposium, 2004
While there have been significant improvements in breast cancer therapy over the last few decades, the fact that metastatic breast cancer remains incurable as well as the finding that adjuvant therapy reduces the breast cancer death hazard ratio by about 30% only underlines the need for novel therapeutic strategies. Currently, there is much interest in
Per Eystein, Lønning, Svein Inge, Helle
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While there have been significant improvements in breast cancer therapy over the last few decades, the fact that metastatic breast cancer remains incurable as well as the finding that adjuvant therapy reduces the breast cancer death hazard ratio by about 30% only underlines the need for novel therapeutic strategies. Currently, there is much interest in
Per Eystein, Lønning, Svein Inge, Helle
openaire +1 more source