Results 81 to 90 of about 18,629 (186)
Stimulating proteasomal degradation in human proteinopathies
The FEBS Journal, Volume 293, Issue 18, Page 5514-5540, September 2026.The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch +2 more
wiley +1 more source
Targeting the insulin-like growth factor-1 receptor in human cancer
Frontiers in Pharmacology, 2013 The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-tumor agents are being developed.
Alexandre eArcaro
doaj +1 more source
Skin Research and Technology, Volume 32, Issue 9, September 2026.ABSTRACT Background Condyloma acuminata (CA) is clinically associated with localized immunosuppression, yet the mechanisms underlying HPV‐mediated immune evasion remain poorly understood. Although the long non‐coding RNA MIR31HG has been implicated in inflammatory regulation, its role in the immunosuppressive microenvironment of CA has not been ...
Xiaohang Xie +4 more
wiley +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Translational Oncology, 2016 To determine what alternative pathways may act as mechanisms of bypass resistance to type 1 insulin-like growth factor receptor (IGF-1R) blockade in rhabdomyosarcoma (RMS), we compared expression of receptor tyrosine kinase activity in a number of IGF-1R
Christine M. Heske +6 more
doaj +1 more source
Molecular Oncology, 2016 The activation status of the insulin‐like growth factor‐1 receptor (IGF‐1R) regulates the cellular response of keratinocytes to ultraviolet B (UVB) exposure, both in vitro and in vivo.
Mathew M. Loesch +7 more
doaj +1 more source
Zhongguo linchuang yanjiuObjective To investigate the serum levels of insulin-like growth factor 1 (IGF-1), IGF-1 receptor (IGF-1R), and brain-derived neurotrophic factor (BDNF) in pregnant women with gestational diabetes mellitus (GDM) and neonatal umbilical cord blood, and ...
SONG Yuanli*, SHAO Fang, XUE Juan
doaj +1 more source
TSHR/IGF-1R Cross-Talk, Not IGF-1R Stimulating Antibodies, Mediates Graves' Ophthalmopathy Pathogenesis [PDF]
Thyroid, 2017 Christine C, Krieger +3 more
openaire +2 more sources
Investigating the role of IGF-1R in radio-sensitivity
, 2020 The insulin-like growth factor (IGF) axis is an important regulator of cancer cell proliferation, growth, invasion, and can also mediate therapy resistance. Inhibition or depletion of the type 1 IGF receptor (IGF-1R) has been shown by our laboratory and others to enhance sensitivity to ionising radiation (IR) and chemotherapy, and to impair repair of ...
openaire +1 more source
Zhongguo aizheng zazhi, 2016 Background and purpose: Insulin-like growth factor-1 (IGF-1) is a peptide that participates in many biological processes by stimulating the downstream signaling pathways through their interaction with IGF-1 receptor (IGF-1R) and insulin receptor (IR ...
傅敬忠, 黄龙璋
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