Results 181 to 190 of about 152,806 (342)

Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD

Developmental Dynamics, EarlyView.
Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim, You‐Lim Hwang, Sunwoo Yeom, Seung‐Hae Kwon, Sang‐Hak Jeon   +4 more
wiley   +1 more source

Knockdown of IGF-1R Triggers Viral RNA Sensor MDA5- and RIG-I-Mediated Mitochondrial Apoptosis in Colonic Cancer Cells

Molecular Therapy: Nucleic Acids, 2019
The important role of insulin-like growth factor-1 receptor (IGF-1R) in tumorigenesis has been well established. The classical model involves IGF-1R binding to IGF-1/2, the following activation of PI3K-Akt-signaling cascades, driving cell proliferation ...
Shu-Qing Wang, Xiang-Yu Yang, Xin-Feng Yu, Shu-Xiang Cui, Xian-Jun Qu   +4 more
doaj  

Model-Based Analysis of IGF-I Response, Dosing, and Monitoring for Once-Weekly Somapacitan in Children With GH Deficiency. [PDF]

J Endocr Soc, 2023
Kildemoes RJ, Backeljauw PF, Højby M, Blair JC, Miller BS, Mori J, Lyauk YK.   +6 more
europepmc   +1 more source

Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Measurements in the Diagnosis of Growth Hormone Insufficiency and Comparison with IGF-I Measurements

, 1993
Yukihiro Hasegawa, Tomonobu Hasegawa, Shinobu Kotoh, Yutaka Tsuchiya   +3 more
openalex   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T.

, 1990
James R. Florini, Daina Z. Ewton
openalex   +1 more source

Insulin-like Growth Factor (IGF)-I, -II, IGF Binding Proteins (IGFBP)−3, −4, and −5 Levels in the Conditioned Media of Normal Human Bone Cells Are Skeletal Site-Dependent [PDF]

, 1997
Rashmi Malpe, David J. Baylink, Thomas A. Linkhart, Jon E. Wergedal, Subburaman Dr. Mohan   +4 more
openalex   +1 more source

Two‐year outcomes of a cardiac microcurrent device in chronic heart failure: A first‐in‐human pilot study

ESC Heart Failure, EarlyView.
Abstract Aims In heart failure patients, altered myocardial electrical fields linked to oedema may impair left ventricular function. While short‐term use of implanted microcurrent generators (C‐MIC) has shown promise, long‐term effects remain unclear.
Dragana B. Kosevic, Una Radak, Petar Vukovic, Jan D. Schmitto, Kersten Brandes, Peter Goettel, Hans‐Dirk Duengen, Elvis Tahirovic, Marija Zdravkovic, Johannes Mueller, Faouzi Kallel, Marat Fudim, Stefan D. Anker, Jesus Eduardo Rame, Miodrag Peric   +14 more
wiley   +1 more source

Aging and IGF-I: relationships with vitamin D and body composition. A mediation analysis. [PDF]

Front Nutr
Vicinanza R, Frizza A, Pollard JA, Mazza V, De Martino MU, Imbimbo G, Pignatelli P, Ettorre E, Del Ben M, Molfino A.   +9 more
europepmc   +1 more source

IGF-I binding and IGF-I mRNA expression in the post-ischemic regenerating rat kidney

, 1992
Göran Matejka, Eva Jennische
openalex   +1 more source