Results 181 to 190 of about 112,948 (243)

Age Does Not Affect Respiratory Characteristics in Children With Prader‐Willi Syndrome Before and After Growth Hormone Therapy

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim Children with Prader‐Willi syndrome (PWS) are at increased risk of both central (CSA) and obstructive sleep apnoea (OSA). Studies examining the effects of growth hormone have focused on older children; however, therapy is often initiated before the age of 2 years.
Michelle Ip   +7 more
wiley   +1 more source

Disordered Bile Acid Metabolism in Alcohol‐Related Hepatitis

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Serum conjugated primary bile acids accumulate in alcohol‐related hepatitis due to downregulation of hepatocyte bile acid transporters. Hepatocyte growth factor is elevated in alcohol‐related hepatitis and downregulates BSEP expression. This detrimentally affects the hepatoprotective adaptive reduction in NTCP/increase in BSEP seen in cholestasis ...
Luke D. Tyson   +22 more
wiley   +1 more source

A Clinical Study of the Distribution and Morphology of Harris Lines

open access: yesArchaeometry, EarlyView.
ABSTRACT Harris lines are commonly used in bioarcheology to infer lifestyle in ancient populations; however, their etiology and identification parameters are still under debate. The aim of this study is to observe the distribution of the lesions in a contemporary clinical sample to address their association with etiological factors, age, biological sex,
Claudia Moro   +7 more
wiley   +1 more source

Circulating levels of insulin‐like growth factor I (IGF‐I) and risk of multiple myeloma: An observational and Mendelian randomisation study

open access: yesBritish Journal of Haematology, EarlyView.
Summary Evidence for an association between insulin‐like growth factors (IGF) and multiple myeloma (MM) is inconsistent. We examined total IGF‐I concentrations and risk of MM by combining baseline serological data among UK Biobank participants (n = 444 187; 732 incident MM) with a two‐sample Mendelian randomisation (MR) analysis using identified ...
Yolanda Benavente   +56 more
wiley   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata   +13 more
wiley   +1 more source

Associations Between Obesity, Diabetes Mellitus, and Pancreatic Cancer in the Japanese Population: A Mendelian Randomization Study

open access: yesCancer Science, EarlyView.
Our Mendelian Randomization analysis provides evidence supporting a causal association between genetic predisposition to T2D, independent of BMI, and an increased risk of pancreatic cancer in the Japanese population, corroborating findings from observational studies.
Yingsong Lin   +41 more
wiley   +1 more source

Niedobór IGF-I

open access: yesEndokrynologia Polska (Polish Journal of Endocrinology), 2016
openaire  

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