Results 201 to 210 of about 21,502,425 (295)

Tissue explants as tools for studying the epigenetic modulation of the GH-IGF-I axis in farmed fish. [PDF]

Front Physiol
Perera E, Román-Padilla J, Hidalgo-Pérez JA, Huesa-Cerdán R, Yúfera M, Mancera JM, Martos-Sitcha JA, Martínez-Rodríguez G, Ortiz-Delgado JB, Navarro-Guillén C, Rodriguez-Casariego JA.   +10 more
europepmc   +1 more source

Recent Advances in Cryogel Applications for Musculoskeletal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer. [PDF]

Clin Res Cardiol
Fröhlich AK, Porthun J, Talha KM, Lena A, Hadzibegovic S, Wilkenshoff U, Sonntag F, Nikolski A, Ramer LV, Zeller T, Keller U, Bullinger L, Anker SD, Haverkamp W, von Haehling S, Doehner W, Rauch U, Skurk C, Cleland JGF, Butler J, Coats AJS, Landmesser U, Karakas M, Anker MS.   +23 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

The somatotroph pituitary gland function in high-aged multimorbid hospitalized patients with IGF-I deficiency. [PDF]

Pituitary
Tausendfreund O, Bidlingmaier M, Martini S, Reif H, Rippl M, Schilbach K, Schmidmaier R, Drey M.   +7 more
europepmc   +1 more source

Depot‐Specific Insulin Receptor Isoform Dynamics During Human Adipose‐Derived Stem Cell Adipogenesis

Obesity, EarlyView.
Absolute quantification reveals depot‐specific insulin receptor (IR) isoform signatures in human adipose stem cells, with subcutaneous cells enriched in IRa and exhibiting greater adipogenic capacity and insulin responsiveness. The emergence of IR‐negative adipocytes highlights partially receptor‐independent pathways regulating human adipogenesis ...
Valentina Annamaria Genchi, Celeste Lauriola, Cristina Caccioppoli, Rossella D'Oria, Nicola Marrano, Giuseppina Biondi, Sebastio Perrini, Annalisa Natalicchio, Luigi Laviola, Francesco Giorgino, Angelo Cignarelli   +10 more
wiley   +1 more source

Basalt Fiber Surface Modification for Improved Interaction With Polyamide‐6 for High‐Performance Automotive Applications

Polymer Composites, EarlyView.
Amino‐silane treatment improves the basalt fiber–PA6 interface, enhancing composite performance. ABSTRACT Basalt fiber‐reinforced polymer (BFRP) composites have emerged as sustainable alternatives to glass fiber (GF) composites, but their performance is often controlled by the quality of the fiber–matrix adhesion.
Mohammad Mezbah Ul Hoque, Manuel Garcia‐Perez, Manuel Raul Pelaez‐Samaniego, Vikram Yadama   +3 more
wiley   +1 more source

Somapacitan in Children Born SGA: 52-Week Efficacy, Safety, and IGF-I Response Results From the Phase 2 REAL5 Study.

J Clin Endocrinol Metab
Juul A, Backeljauw P, Højby M, Frystyk J, Kawai M, Kildemoes RJ, Lemminger AK, Linglart A, Zuckerman-Levin N, Horikawa R.   +9 more
europepmc   +1 more source

Evaluating the role of preoperative serum insulin-like growth factor 1 as a predictor of survival and recurrence for patients with resectable hepatocellular carcinoma. [PDF]

J Gastrointest Surg
Eid J, Haddad A, Hassan M, Amin HM, Newhook TE, Chun YS, Tzeng CD, Vauthey JN, Tran Cao HS, Kaseb AO.   +9 more
europepmc   +1 more source

Genomics and epigenomics of tissue repair: Implications for personalized medicine

Precision Medical Sciences, EarlyView.
Genomic and epigenomic mechanisms govern tissue repair and regeneration through dynamic regulation of inflammation, cell fate, and extracellular matrix remodeling. The integration of multi‐omics, artificial intelligence, and precision regenerative therapies enables biomarker‐driven, personalized approaches to enhance healing and minimize fibrosis ...
Jharna Medhi, Chandrashekar Thalluri, Sarad Pawar Naik Bukke, Piyali Dey, Mallikarjun Vasam, Ananda Kumar Chettupalli, Swetha Kumari Koduru, Gali Avinash Kumar   +7 more
wiley   +1 more source