Results 211 to 220 of about 115,801 (264)
Some of the next articles are maybe not open access.
Growth Hormone & IGF Research, 2005
An intriguing relationship between IGF-I action and cardiac function has been noted for some time, but exactly how IGF-I modulates myocardial function remained obscure. Recent research shed novel insight into potential mechanisms of IGF-I actions in cardiac muscle.
Ole, Saetrum Opgaard, Ping H, Wang
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An intriguing relationship between IGF-I action and cardiac function has been noted for some time, but exactly how IGF-I modulates myocardial function remained obscure. Recent research shed novel insight into potential mechanisms of IGF-I actions in cardiac muscle.
Ole, Saetrum Opgaard, Ping H, Wang
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Current Pharmaceutical Design, 2007
The insulin-like growth factor (IGF)-I is implicated in the regulation of protein turnover and exerts potent mitogenic and differentiating effects on most cell types. IGF-I biological actions are mediated by the IGF-I receptor, comprised of two extra-cellular alpha-subunits, containing hormone binding sites, and two membrane-spanning beta-subunits ...
LAVIOLA, Luigi +2 more
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The insulin-like growth factor (IGF)-I is implicated in the regulation of protein turnover and exerts potent mitogenic and differentiating effects on most cell types. IGF-I biological actions are mediated by the IGF-I receptor, comprised of two extra-cellular alpha-subunits, containing hormone binding sites, and two membrane-spanning beta-subunits ...
LAVIOLA, Luigi +2 more
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Distribution of IGF-I mRNA and IGF-I binding sites in the rat kidney
Histochemistry, 1992In the present study we have investigated the distribution of IGF-I mRNA and IGF-I binding sites in the rat kidney. The distribution of IGF-I mRNA was investigated using a simple and sensitive non-radioactive in situ hybridisation technique based on probe labelling with digoxigenin labelled-UTP followed by detection with conventional immunocytochemical
G L, Matejka +3 more
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The IGF-I/IGF-I Receptor Pathway: Implications in the Pathophysiology of Thyroid Cancer
Current Medicinal Chemistry, 2005The biological actions of the insulin-like growth factor(IGF)-I are mediated by its activation of the IGF-I receptor (IGF-I R), a transmembrane tyrosine kinase linked to the Akt and ras-raf-MAPK cascades. A functional IGF-I R is required for the cell to progress through the cell cycle. Most importantly, cells lacking this receptor cannot be transformed
CIAMPOLILLO A +2 more
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Molecular and Cellular Endocrinology, 1994
Limited information is available concerning the molecular and cellular mechanisms that regulate expression of insulin-like growth factor-I (IGF-I) binding proteins (IGFBPs) in bovine mammary epithelial cells. Here, we report on the autocrine mechanisms of action of IGF-I and hormonal regulation of expression of IGFBPs in bovine mammary epithelial MD ...
D, Ramagnolo +4 more
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Limited information is available concerning the molecular and cellular mechanisms that regulate expression of insulin-like growth factor-I (IGF-I) binding proteins (IGFBPs) in bovine mammary epithelial cells. Here, we report on the autocrine mechanisms of action of IGF-I and hormonal regulation of expression of IGFBPs in bovine mammary epithelial MD ...
D, Ramagnolo +4 more
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Acta Endocrinologica, 1987
Abstract. Binding of 125I-insulin-like growth factor-I and 125I-ovine somatomedin-C/IGF-I to monolayer cultures of muscle-derived ovine fibroblasts is described. Preliminary competitive binding experiments indicate that ovine fibroblasts possess independent cell surface receptors for IGF-I.
M V, Dodson, B A, Mathison, K L, Hossner
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Abstract. Binding of 125I-insulin-like growth factor-I and 125I-ovine somatomedin-C/IGF-I to monolayer cultures of muscle-derived ovine fibroblasts is described. Preliminary competitive binding experiments indicate that ovine fibroblasts possess independent cell surface receptors for IGF-I.
M V, Dodson, B A, Mathison, K L, Hossner
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Growth Hormone & IGF Research, 2008
To determine whether different albumins have an effect on IGF-I binding assays.We have studied the effect of five different albumins in plate antibody capture binding assay. For IGF-IR studies the IGF-IR specific antibody 24-31 was used and for IR/IGF-IR hybrid receptors the IR specific antibody 83-7 was used.
Rita, Slaaby +2 more
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To determine whether different albumins have an effect on IGF-I binding assays.We have studied the effect of five different albumins in plate antibody capture binding assay. For IGF-IR studies the IGF-IR specific antibody 24-31 was used and for IR/IGF-IR hybrid receptors the IR specific antibody 83-7 was used.
Rita, Slaaby +2 more
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Patient Selection for IGF-I Therapy
Hormone Research, 2006• Many patients previously classified as 'idiopathic short stature' have Primary IGFD. In some studies, this number is as high as 50%. • For patients with severe Primary IGFD, treatment of choice should be IGF-I, either alone or in combination with IGFBP-3.
Clayton, P. E.; id_orcid 0000-0003-1225-4537 +2 more
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Molecular Reproduction and Development, 1993
AbstractConstitutive overexpression of the insulin‐like growth factor‐I (IGF‐I) receptor makes 3T3 cells capable of growing in serum‐free medium supplemented solely with IGF‐I to the total exclusion of the platelet‐derived growth factor (PDGF) and epidermal growth factor (EGF) receptors, the other two receptors that are required for the growth of 3T3 ...
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AbstractConstitutive overexpression of the insulin‐like growth factor‐I (IGF‐I) receptor makes 3T3 cells capable of growing in serum‐free medium supplemented solely with IGF‐I to the total exclusion of the platelet‐derived growth factor (PDGF) and epidermal growth factor (EGF) receptors, the other two receptors that are required for the growth of 3T3 ...
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2018
Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are relevant regulators of bone homeostasis throughout human life, acting on both the trabecular and cortical bone [1]. The anabolic effects of these hormones are important to reach an adequate bone mass during puberty and early adulthood—a critical determinant for the future risk of ...
Frara, Stefano +5 more
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Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are relevant regulators of bone homeostasis throughout human life, acting on both the trabecular and cortical bone [1]. The anabolic effects of these hormones are important to reach an adequate bone mass during puberty and early adulthood—a critical determinant for the future risk of ...
Frara, Stefano +5 more
openaire +2 more sources