Results 231 to 240 of about 21,502,425 (295)
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Hormone Research in Paediatrics, 2004
Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several animal models.
J A M J L, Janssen, S W J, Lamberts
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Recent animal studies have demonstrated evidence of the involvement of insulin and insulin-like growth factor (IGF)-I signalling in the control of ageing and longevity. Disruption of insulin/IGF-I signalling pathways significantly extends lifespan in several animal models.
J A M J L, Janssen, S W J, Lamberts
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IGF‐I and the IGF‐I receptor in development of nonmammalian vertebrates
Molecular Reproduction and Development, 1993AbstractExtracellular signals are likely to be involved in the control of growth and differentiation during embyrogenesis of vertebrates. These signals include, among others, several members of the insulin family: insulin‐like growth factor (IGF)‐I, IGF‐II, and insulin. In the chick embryo, maternal IGF‐I is stored in the yolk.
F, de Pablo +7 more
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Journal of Endocrinology, 1997
Abstract We have previously demonstrated that a specific antiIGF-I antibody will enhance the growth-promoting activity of IGF-I in vivo (Stewart et al. 1993). Since the antibody had a modest affinity for IGF-I we suggested that the antiserum might protect IGF-I from degradation whilst maintaining it in a bioavailable form.
R A, Hill +3 more
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Abstract We have previously demonstrated that a specific antiIGF-I antibody will enhance the growth-promoting activity of IGF-I in vivo (Stewart et al. 1993). Since the antibody had a modest affinity for IGF-I we suggested that the antiserum might protect IGF-I from degradation whilst maintaining it in a bioavailable form.
R A, Hill +3 more
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IGF-I and IGF-I Receptor Polymorphisms Among Elite Swimmers
Pediatric Exercise Science, 2014In recent years several genetic polymorphisms related to the GH-IGF-I axis were suggested to promote athletic excellence in endurance and power sports. We studied the presence of the C-1245T SNP (rs35767), a nucleotide substitution in the promoter region of the IGF-I gene, and the presence of the 275124A > C SNP (rs1464430), a common nucleotide ...
Sigal, Ben Zaken +4 more
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Clinics in Laboratory Medicine, 2000
Serum IGF-I is controlled by several different regulatory factors. The final adult level represents the sum of the inert circulating depot, newly derived IGF-I synthesized from various tissues including liver, heart, kidney, bone, and others, and the departure from the circulation of IGF-I through mechanisms including receptor internalization and ...
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Serum IGF-I is controlled by several different regulatory factors. The final adult level represents the sum of the inert circulating depot, newly derived IGF-I synthesized from various tissues including liver, heart, kidney, bone, and others, and the departure from the circulation of IGF-I through mechanisms including receptor internalization and ...
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Localization of IGF-I and IGF-I Receptor mRNA inSparus aurataLarvae
General and Comparative Endocrinology, 1997Studies of the ontogeny of IGF-I mRNA during embryonic and larval development of the gilthead sea bream Sparus aurata showed its expression during these early developmental stages. The present study applies in situ hybridization to localize IGF-I and IGF receptor mRNAs in 16-day larvae of S. aurata. Paraffin sections were hybridized with homologous RNA
B, Funkenstein, R, Almuly, S J, Chan
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Current Pharmaceutical Design, 2007
The insulin-like growth factor (IGF)-I is implicated in the regulation of protein turnover and exerts potent mitogenic and differentiating effects on most cell types. IGF-I biological actions are mediated by the IGF-I receptor, comprised of two extra-cellular alpha-subunits, containing hormone binding sites, and two membrane-spanning beta-subunits ...
LAVIOLA, Luigi +2 more
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The insulin-like growth factor (IGF)-I is implicated in the regulation of protein turnover and exerts potent mitogenic and differentiating effects on most cell types. IGF-I biological actions are mediated by the IGF-I receptor, comprised of two extra-cellular alpha-subunits, containing hormone binding sites, and two membrane-spanning beta-subunits ...
LAVIOLA, Luigi +2 more
openaire +3 more sources