Results 221 to 230 of about 115,801 (264)
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Hormone Research, 2006
• The IGF system is the major mediator of both intra-uterine and postnatal growth. • The IGF-I receptor appears to mediate the growth-promoting effects of both IGF-I and IGF-II. • The role of IGF binding proteins in mediating the growth-promoting actions of the IGFs is complex and remains incompletely understood.
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• The IGF system is the major mediator of both intra-uterine and postnatal growth. • The IGF-I receptor appears to mediate the growth-promoting effects of both IGF-I and IGF-II. • The role of IGF binding proteins in mediating the growth-promoting actions of the IGFs is complex and remains incompletely understood.
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The IGF-I Axis in Thyroid Carcinoma
Current Pharmaceutical Design, 2007Insulin like-growth factor I (IGF-I) has been involved in the pathogenesis of a variety of human neoplasia due to the mitogenic and anti-apoptotic properties of its cognate receptor. In human thyroid carcinomas, we have previously documented an increased immunoreactivity of both IGF-I and the IGF-I receptor (IGF-I R) associated with up regulation of ...
Ciampolillo A +3 more
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Regulatory Peptides, 1994
To characterize the expression of the IGF-I system in the spleen and its role in spleen growth, we have studied the effect of hypophysectomy and the action of either GH or IGF-I treatment on the expression of several components of the IGF system in the rat.
H M, Domené +6 more
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To characterize the expression of the IGF-I system in the spleen and its role in spleen growth, we have studied the effect of hypophysectomy and the action of either GH or IGF-I treatment on the expression of several components of the IGF system in the rat.
H M, Domené +6 more
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Aged Human Thymus Hassall's Corpuscles Are Immunoreactive for IGF‐I and IGF‐I Receptor
The Anatomical Record, 2009AbstractAlthough Hassall's corpuscles have been proposed to act in both maturation of developing thymocytes and removal of apoptotic cells, their function remains an enigma. The involvement of insulin‐like growth factor I (IGF‐I) in the local autocrine and paracrine control of T‐cell development in human thymus is still unclear.
Tsvetana Ts, Marinova +7 more
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Simulation of IGF-I pharmacokinetics after infusion of recombinant IGF-I in human subjects
American Journal of Physiology-Endocrinology and Metabolism, 1997The pharmacokinetics of recombinant human insulin-like growth factor I (IGF-I) were studied in four healthy volunteers by a 3-h infusion at a rate of 20 micrograms.kg-1.h-1. A compartmental model was used to simulate the plasma “free” IGF-I and IGF-I associated with the 50- and 150-kDa plasma protein fractions.
Boroujerdi, Massoud +3 more
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IGF‐I binding and IGF‐I expression in regenerating muscle of normal and hypophysectomized rats
Acta Physiologica Scandinavica, 1992Binding of iodinated IGF‐I to tissue sections from regenerating muscle was studied by autoradiography in normal and in hypophysectomized rats. Binding of IGF‐I was low in control muscle in both groups of animals, but increased transiently about 10‐fold during regeneration after injury.
E, Jennische, G L, Matejka
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Binding of IGF I and IGF I-stimulated phosphorylation in canine renal basolateral membranes
American Journal of Physiology-Endocrinology and Metabolism, 1986To characterize the interaction of the renal proximal tubular cell with insulin like growth factor I (IGF I), we measured binding of 125I-IGF I to proximal tubular basolateral membranes from dog kidney and induced IGF I-stimulated phosphorylation of basolateral membranes.
M R, Hammerman, J R, Gavin
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Expression of IGF-I and IGF-I Receptor Gene in the Corpus Luteum
1991Insulin-like growth factors (IGFs) are peptide mitogens that have been implicated in growth and development of the rat ovary. Insulin-like growth factor I (IGF-I) has been shown to affect granulosa cell proliferation and differentiation in vitro (1).Recent investigations indicate that granulosa cells produce IGF-I and IGF-I binding proteins (2) and are
T. G. Parmer +4 more
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Analysis of the Interaction of IGF-I Analogs with the IGF-I Receptor and IGF Binding Proteins
1994Distinct domains of IGF-I are important for maintaining high affinity for the IGF-I receptor and for the various species of IGFBPs. The analogs that selectively bind the receptor have proven useful in determining the relative importance of IGFBPs in the regulation of the biological activity of IGF-I.
M A, Cascieri, M L, Bayne
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IGF-I in Human Growth: Lessons from Defects in the GH-IGF-I Axis
2013The IGF system plays a critical role in all phases of human growth, including intrauterine, childhood and pubertal. The importance of IGF-I for both in utero as well as postnatal human growth is highlighted by rare human homozygous IGF1 mutations, which are characterized by intrauterine growth retardation (IUGR), microcephaly, mental retardation and ...
Vivian, Hwa +4 more
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